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ADRA1A Rabbit pAb (bs-0600R)  
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產品編號 bs-0600R
英文名稱 ADRA1A Rabbit pAb
中文名稱 alpha 1腎上腺素能受體A抗體
別    名 ADA1A_HUMAN; Adrenergic alpha 1A receptor; Adrenergic alpha 1C receptor; Adrenergic alpha 1D receptor; alpha 1 Adrenergic Receptor; alpha 1A adrenergic receptor; alpha-1A adrenergic receptor; alpha-1A adrenoreceptor; alpha-1C adrenergic receptor; alpha-adrenergic receptor 1c; ADRA1A; ADRA1C; alpha 1A adrenoceptor; alpha-1A adrenergic receptor isoform 1; adrenergic, alpha-1A-, receptor variant 1; adrenergic, alpha-1A-, receptor variant 3; adrenergic, alpha-1A-, receptor variant 5; adrenergic, alpha-1A-, receptor variant 8; G protein coupled receptor; alpha-1A adrenoceptor; ADRA1L1; ALPHA1AAR.  
Specific References  (4)     |     bs-0600R has been referenced in 4 publications.
[IF=7.84] Chen, Li-You, et al. "Early-life sleep deprivation persistently depresses melatonin production and bio-energetics of the pineal gland: potential implications for the development of metabolic deficiency." Brain Structure and Function (2014): 1-14.  WB ;  Rat.  
[IF=4.37] Wang, Wenjuan, et al. "Effects of Estradiol Valerate and Remifemin on Norepinephrine Signaling in the Brain of Ovariectomized Rats."Neuroendocrinology 101.2 (2015): 120-132.  IHC-F ;  Rat.  
[IF=2.59] Sun, Tao, et al. "Antihypertensive effect of formononetin through regulating the expressions of eNOS, 5-HT< sub> 2A/1B receptors and α< sub> 1-adrenoceptors in spontaneously hypertensive rat arteries." European Journal of Pharmacology (2013).  Rat.  
[IF=2.532] Jianchao Ren. et al. Ejaculatory Duct Obstruction Affects Seminal Vesicle Contractile Efficacy and Smooth Muscle Ultrastructure in a Rat Model. ANDROLOGIA. 2023;2023:5022466  WB ;  Rat.  
研究領域 細胞生物  神經生物學  細胞膜受體  
抗體來源 Rabbit
克隆類型 Polyclonal
克 隆 號
交叉反應 Mouse,Rat (predicted: Human,Rabbit,Pig,Sheep,Cow,Chicken,Dog,GuineaPig,Horse)
產品應用 WB=1:500-2000,IHC-P=1:100-500,IHC-F=1:100-500,IF=1:100-500
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
理論分子量 51 kDa
檢測分子量
細胞定位 細胞核 細胞膜 
性    狀 Liquid
濃    度 1mg/ml
免 疫 原 KLH conjugated synthetic peptide derived from human Alpha-1A adrenergic receptor: 201-300/466 
亞    型 IgG
純化方法 affinity purified by Protein A
緩 沖 液 0.01M TBS (pH7.4) with 1% BSA, 0.02% Proclin300 and 50% Glycerol.
保存條件 Shipped at 4℃. Store at -20℃ for one year. Avoid repeated freeze/thaw cycles.
注意事項 This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
PubMed PubMed
產品介紹 Alpha-1-adrenergic receptors (alpha-1-ARs) are members of the G protein-coupled receptor superfamily. They activate mitogenic responses and regulate growth and proliferation of many cells. There are 3 alpha-1-AR subtypes: alpha-1A, -1B and -1D, all of which signal through the Gq/11 family of G-proteins and different subtypes show different patterns of activation. This gene encodes alpha-1A-adrenergic receptor. Alternative splicing of this gene generates four transcript variants, which encode four different isoforms with distinct C-termini but having similar ligand binding properties. [provided by RefSeq, Jul 2008].

Function:
This alpha-adrenergic receptor mediates its action by association with G proteins that activate a phosphatidylinositol-calcium second messenger system. Its effect is mediated by G(q) and G(11) proteins. Nuclear ADRA1A-ADRA1B heterooligomers regulate phenylephrine(PE)-stimulated ERK signaling in cardiac myocytes.

Subunit:
Homo- and heterooligomer. Heterooligomerizes with ADRA1B homooligomers in cardiac myocytes.

Subcellular Location:
Nucleus membrane; Multi-pass membrane protein. Cell membrane; Multi-pass membrane protein. Note=Location at the nuclear membrane facilitates heterooligomerization and regulates ERK-mediated signaling in cardiac myocytes. Colocalizes with GNAQ, PLCB1 as well as LAP2 at the nuclear membrane of cardiac myocytes.

Tissue Specificity:
Expressed in heart, brain, liver and prostate, but not in kidney, lung, adrenal, aorta and pituitary. Within the prostate, expressed in the apex, base, periurethral and lateral lobe. Isoform 4 is the most abundant isoform expressed in the prostate with high levels also detected in liver and heart.

Post-translational modifications:
C-terminal Ser or Thr residues may be phosphorylated.

Similarity:
Belongs to the G-protein coupled receptor 1 family. Adrenergic receptor subfamily. ADRA1A sub-subfamily.

SWISS:
P35348

Gene ID:
148

Database links:

Entrez Gene: 148 Human

Entrez Gene: 11549 Mouse

Entrez Gene: 29412 Rat

Omim: 104221 Human

SwissProt: P35348 Human

SwissProt: P97718 Mouse

SwissProt: P43140 Rat

Unigene: 52931 Human

Unigene: 709175 Human

Unigene: 57064 Mouse

Unigene: 9991 Rat



ADRA1腎上腺素能α1受體位于突觸后,在血管平滑肌上,興奮時可使血管收縮;
alpha 1-adrenergic receptor有興奮效應也有抑制效應。腎上腺素能受體又可分為α和β兩種。alpha 受體與兒茶酚胺結合后,主要是興奮平滑肌,如血管收縮、子宮收縮和瞳孔開張肌收縮等;但也有抑制作用,如使小腸平滑肌舒張。β受體又可分為β1和β2兩個亞型.
產品圖片
Sample: Lane 1: Mouse Heart tissue lysates Lane 2: Rat Heart tissue lysates Primary: Anti-ADRA1A (bs-0600R) at 1/1000 dilution Secondary: IRDye800CW Goat Anti-Rabbit IgG at 1/20000 dilution Predicted band size: 51 kDa Observed band size: 47 kDa
Tissue/cell: rat brain tissue; 4% Paraformaldehyde-fixed and paraffin-embedded; Antigen retrieval: citrate buffer ( 0.01M, pH 6.0 ), Boiling bathing for 15min; Block endogenous peroxidase by 3% Hydrogen peroxide for 30min; Blocking buffer (normal goat serum,C-0005) at 37℃ for 20 min; Incubation: Anti-ADRA1/ADRA1B/alpha 1 Adrenergic Receptor Polyclonal Antibody, Unconjugated (bs-0600R) 1:200, overnight at 4°C, followed by conjugation to the secondary antibody(SP-0023) and DAB(C-0010) staining
Tissue/cell: rat brain tissue; 4% Paraformaldehyde-fixed and paraffin-embedded; Antigen retrieval: citrate buffer ( 0.01M, pH 6.0 ), Boiling bathing for 15min; Block endogenous peroxidase by 3% Hydrogen peroxide for 30min; Blocking buffer (normal goat serum,C-0005) at 37℃ for 20 min; Incubation: Anti-ADRA1/ADRA1B/alpha 1 Adrenergic Receptor Polyclonal Antibody, Unconjugated (bs-0600R) 1:200, overnight at 4°C, followed by conjugation to the secondary antibody(SP-0023) and DAB(C-0010) staining
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