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CD272 Rabbit pAb (bs-0624R)  
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產品編號 bs-0624R
英文名稱 CD272 Rabbit pAb
中文名稱 B和T淋巴細胞衰減蛋白抗體
別    名 B and T lymphocyte associated protein; B and T lymphocyte attenuator; B and T lymphocyte associated; BTLA; BTLA1; CD272 antigen; FLJ16065; MGC129743; BTLA_HUMAN; B-and T-lymphocyte attenuator; B-and T-lymphocyte-associated protein.  
研究領域 腫瘤  細胞生物  免疫學  淋巴細胞  t-淋巴細胞  b-淋巴細胞  
抗體來源 Rabbit
克隆類型 Polyclonal
克 隆 號
交叉反應 Human,Mouse,Rat
產品應用 WB=1:500-2000,IHC-P=1:100-500,IHC-F=1:100-500,IF=1:100-500
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
理論分子量 28 kDa
檢測分子量
細胞定位 細胞膜 
性    狀 Liquid
濃    度 1mg/ml
免 疫 原 KLH conjugated synthetic peptide derived from human B and T-lymphocyte attenuator: 221-289/289 <Cytoplasmic>
亞    型 IgG
純化方法 affinity purified by Protein A
緩 沖 液 0.01M TBS (pH7.4) with 1% BSA, 0.02% Proclin300 and 50% Glycerol.
保存條件 Shipped at 4℃. Store at -20℃ for one year. Avoid repeated freeze/thaw cycles.
注意事項 This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
PubMed PubMed
產品介紹 B and T lymphocyte attenuator (BTLA), an immunoglobulin domain-containing glycoprotein with two immunoreceptor tyrosine-based inhibitory motifs. BTLA is not expressed by naive T cells, but it is induced during activation and remains expressed on T helper type 1 (T(H)1) but not T(H)2 cells. Crosslinking BTLA with antigen receptors induces its tyrosine phosphorylation and association with the Src homology domain 2 (SH2)-containing protein tyrosine phosphatases SHP-1 and SHP-2, and attenuates production of interleukin 2 (IL-2). BTLA-deficient T cells show increased proliferation, and BTLA-deficient mice have increased specific antibody responses and enhanced sensitivity to experimental autoimmune encephalomyelitis. B7x, a peripheral homolog of B7, is a ligand of BTLA. Thus, BTLA is a third inhibitory receptor on T lymphocytes with similarities to cytotoxic T lymphocyte-associated antigen 4 (CTLA-4) and programmed death 1 (PD-1).

Function:
Lymphocyte inhibitory receptor which inhibits lymphocytes during immune response.

Subunit:
Interacts with tyrosine phosphatases PTPN6/SHP-1 and PTPN11/SHP-2. Interacts with TNFRSF14/HVEM.

Subcellular Location:
Membrane; Single-pass type I membrane protein (Potential).

Post-translational modifications:
Phosphorylated on Tyr residues by TNFRSF14 and by antigen receptors cross-linking, both inducing association with PTPN6 and PTPN11.
N-glycosylated.

Similarity:
Contains 1 Ig-like V-type (immunoglobulin-like) domain.

SWISS:
Q7Z6A9

Gene ID:
151888

Database links:

Entrez Gene: 151888 Human

Entrez Gene: 208154 Mouse

Entrez Gene: 407756 Rat

Omim: 607925 Human

SwissProt: Q7Z6A9 Human

SwissProt: Q7TSA3 Mouse

SwissProt: Q6PNM1 Rat

Unigene: 445162 Human

Unigene: 38199 Mouse

Unigene: 124474 Rat



BTLA對T細胞的活化、增殖起著重要的負調控作用,BTLA相應配體為TNFR超家族中的皰疹病毒入侵介質(HVEM), 其表達于包括T細胞在內的多種免疫細胞表面。
有學者將他定為CD28的超級族成員,B、T淋巴細胞衰減子-CD272主要用于細胞信號傳導方面的研究。
近來國外學者對BTLA用于抑制腫瘤方面的研究也有了新的進展,認為B、T淋巴細胞衰減子對腫瘤的生長有抑制作用,探索新的腫瘤免疫治療有了新的途徑, 封閉此途徑有可能成為腫瘤免疫治療的新靶點。
產品圖片
Sample: Lane 1: Rat Thymus tissue lysates Lane 2: Rat Lung tissue lysates Primary: Anti-CD272 (bs-0624R) at 1/1000 dilution Secondary: IRDye800CW Goat Anti-Rabbit IgG at 1/20000 dilution Predicted band size: 28 kDa Observed band size: 55 kDa
Tissue/cell: mouse lymphoma tissue; 4% Paraformaldehyde-fixed and paraffin-embedded; Antigen retrieval: citrate buffer ( 0.01M, pH 6.0 ), Boiling bathing for 15min; Block endogenous peroxidase by 3% Hydrogen peroxide for 30min; Blocking buffer (normal goat serum,C-0005) at 37∩ for 20 min; Incubation: Anti-CD272/BTLA Polyclonal Antibody, Unconjugated(bs-0624R) 1:200, overnight at 4∑C, followed by conjugation to the secondary antibody(SP-0023) and DAB(C-0010) staining
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