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ChAT Rabbit pAb (bs-0042R)  
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產品編號 bs-0042R
英文名稱 ChAT Rabbit pAb
中文名稱 ChAT膽堿乙酰轉移酶抗體
別    名 Choline O acetyltransferase; Choline O acetyltransferase; Acetyl CoA choline O acetyltransferase; Acetyl CoA:choline O acetyltransferase; ChAT; CHOACTase; Choline acetylase; choline acetyltransferase; CMS1A; CMS1A2; EC 2.3.1.6; OTTHUMP00000019583; OTTHUMP00000019584; CLAT_HUMAN.  
Specific References  (12)     |     bs-0042R has been referenced in 12 publications.
[IF=5.135] Wei Lu. et al. Effects of targeted muscle reinnervation on spinal cord motor neurons in rats following tibial nerve transection. Neural Regen Res. 2022 Jan;17(8):1827  IHC ;  Rat.  
[IF=4.45] Wieck, Minna M., et al. "Human and murine tissue-engineered colon exhibit diverse neuronal subtypes and can be populated by enteric nervous system progenitor cells when donor colon is aganglionic." Tissue Engineering A (2015).  IHC-P ;  Human.  
[IF=4.259] Wang,et al.Stimulation of Epicardial Sympathetic Nerves at Different Sites Induces Cardiac Electrical Instability to Various Degrees.(2018) Scientific Reports. 8:994.  IHC-P ;  Dog.  
[IF=3.856] Daisuke Koga. et al. Applications of Scanning Electron Microscopy Using Secondary and Backscattered Electron Signals in Neural Structure. Front Neuroanat. 2021; 15: 759804  IF ;  Rat.  
[IF=3.842] Chen L et al. Enteric motor dysfunctions in experimental chronic pancreatitis: Alterations of myenteric neurons regulating colonic motility in rats. Neurogastroenterol Motil. 2018 Jul;30(7):e13301.  IF ;  Rat.  
[IF=3.58] Zhang, Xiuli, et al. "Catalpol improves cholinergic function and reduces inflammatory cytokines in the senescent mice induced by D-galactose."Food and chemical toxicology 58 (2013): 50-55.  IHC-P ;  Mouse.  
[IF=3.536] Zhang,et al.Effects of C1 inhibitor on endothelial cell activation in a rat hind limb ischemia-reperfusion injury model.(2018) Journal of Vascular Surgery. :.  IF(IHC-F) ;  Rat.  
[IF=3.53] Zhang Y, Zheng S, Geng Y, Xue J, Wang Z, et al. (2015) MicroRNA Profiling of Atrial Fibrillation in Canines: MiR-206 Modulates Intrinsic Cardiac Autonomic Nerve Remodeling by Regulating SOD1. PLoS ONE 10(3): e0122674.  other ;  Dog.  
[IF=3.508] Wieck et al. Human and Murine Tissue-Engineered Colon Exhibit Diverse Neuronal Subtypes and Can Be Populated by Enteric Nervous System Progenitor Cells When Donor Colon Is Aganglionic. (2016) Tissue.Eng.Part.A. 22:53-64  IHC-P ;  Human.  
[IF=2.74] Jiasuoer Xiaokereti. et al. Enhanced atrial internal-external neural remodeling facilitates atrial fibrillation in the chronic obstructive sleep apnea model. Plos One. 2021 Feb;16(2):e0247308  WB,IHC ;  Dog.  
[IF=2.655] Xiaokereti, Jiasuoer. et al. Renal denervation alleviates chronic obstructive sleep apnea-induced atrial fibrillation via inhibition of atrial fibrosis and sympathetic hyperactivity. SLEEP BREATH. 2023 Feb;:1-14  IF ;  Dog.  
[IF=2.014] Li LI. et al. The antibacterial activity of Berberis heteropoda Schrenk and its effect on irritable bowel syndrome in rats. Chin J Nat Medicines. 2020 May;18:356  IHC ;  Rat.  
研究領域 神經生物學  Alzheimer's  
抗體來源 Rabbit
克隆類型 Polyclonal
克 隆 號
交叉反應 Human
產品應用 WB=1:500-2000,Flow-Cyt=1ug/Test
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
理論分子量 82 kDa
檢測分子量
細胞定位 細胞核 細胞漿 
性    狀 Liquid
濃    度 1mg/ml
免 疫 原 KLH conjugated synthetic peptide derived from human ChAT: 101-200/748 
亞    型 IgG
純化方法 affinity purified by Protein A
緩 沖 液 0.01M TBS (pH7.4) with 1% BSA, 0.02% Proclin300 and 50% Glycerol.
保存條件 Shipped at 4℃. Store at -20℃ for one year. Avoid repeated freeze/thaw cycles.
注意事項 This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
PubMed PubMed
產品介紹 This gene encodes an enzyme which catalyzes the biosynthesis of the neurotransmitter acetylcholine. This gene product is a characteristic feature of cholinergic neurons, and changes in these neurons may explain some of the symptoms of Alzheimer's disease. Polymorphisms in this gene have been associated with Alzheimer's disease and mild cognitive impairment. Mutations in this gene are associated with congenital myasthenic syndrome associated with episodic apnea. Multiple transcript variants encoding different isoforms have been found for this gene, and some of these variants have been shown to encode more than one isoform. [provided by RefSeq, May 2010].

Function:
Catalyzes the reversible synthesis of acetylcholine (ACh) from acetyl CoA and choline at cholinergic synapses.

DISEASE:
Defects in CHAT are the cause of congenital myasthenic syndrome with episodic apnea (CMSEA) [MIM:254210]; formerly known as familial infantile myasthenia gravis 2 (FIMG2). CMSEA is an autosomal recessive congenital myasthenic syndrome. Patients have myasthenic symptoms since birth or early infancy, negative tests for anti-AChR antibodies, and abrupt episodic crises with increased weakness, bulbar paralysis, and apnea precipitated by undue exertion, fever, or excitement.

Similarity:
Belongs to the carnitine/choline acetyltransferase family.

SWISS:
P28329

Gene ID:
1103

Database links:

Entrez Gene: 1103?Human

Entrez Gene: 12647?Mouse

Entrez Gene: 290567?Rat

Omim: 118490?Human

SwissProt: P28329?Human

SwissProt: Q03059?Mouse

SwissProt: P32738?Rat

Unigene: 302002?Human

Unigene: 442817?Mouse

Unigene: 45116?Rat



膽堿乙酰轉移酶是一種在神經元胞體內合成的酶。當該轉移酶被合成以后,通過軸質流動方式轉移到神經軸突末端。其功能是將乙酰輔酶A轉移到膽堿上,導致神經遞質乙酰膽堿的形成。膽堿能系統參與多種神經功能。一些膽堿能神經元的改變能導致阿爾茨海默病的發生。
膽堿乙酰轉移酶通常被用來標記神經元。
產品圖片
Sample: Lane 1: Human SH-SY5Y cell lysates Lane 2: Human U251 cell lysates Primary: Anti-ChAT (bs-0042R) at 1/1000 dilution Secondary: IRDye800CW Goat Anti-Rabbit IgG at 1/20000 dilution Predicted band size: 82 kDa Observed band size: 72 kDa
Blank control: SH-SY5Y. Primary Antibody (green line): Rabbit Anti-ChAT antibody (bs-0042R) Dilution: 1μg /10^6 cells; Isotype Control Antibody (orange line): Rabbit IgG . Secondary Antibody : Goat anti-rabbit IgG-AF647 Dilution: 1μg /test. Protocol The cells were fixed with 4% PFA (10min at room temperature)and then permeabilized with 90% ice-cold methanol for 20 min at-20℃.The cells were then incubated in 5%BSA to block non-specific protein-protein interactions for 30 min at room temperature .Cells stained with Primary Antibody for 30 min at room temperature. The secondary antibody used for 40 min at room temperature. Acquisition of 20,000 events was performed.
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