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MOG Rabbit pAb (bs-0426R)  
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產品編號 bs-0426R
英文名稱 MOG Rabbit pAb
中文名稱 髓鞘少樹突膠質細胞糖蛋白抗體
別    名 MOG_HUMAN; Myelin-oligodendrocyte glycoprotein; Myelin oligodendrocyte glycoprotein; BTN6; BTNL11; MOGIG2; NRCLP7;  
Specific References  (1)     |     bs-0426R has been referenced in 1 publications.
[IF=6.208] Cristina Agliardi. et al. Myelin Basic Protein in Oligodendrocyte-Derived Extracellular Vesicles as a Diagnostic and Prognostic Biomarker in Multiple Sclerosis: A Pilot Study. INT J MOL SCI. 2023 Jan;24(1):894  Human.  
研究領域 細胞生物  神經生物學  信號轉導  干細胞  細胞凋亡  細胞粘附分子  細胞膜蛋白  
抗體來源 Rabbit
克隆類型 Polyclonal
克 隆 號
交叉反應 Mouse,Rat (predicted: Human,Pig,GuineaPig)
產品應用 WB=1:500-2000
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
理論分子量 24 kDa
檢測分子量
細胞定位 細胞膜 
性    狀 Liquid
濃    度 1mg/ml
免 疫 原 KLH conjugated synthetic peptide derived from mouse MOG: 35-55/247 <Extracellular>
亞    型 IgG
純化方法 affinity purified by Protein A
緩 沖 液 0.01M TBS (pH7.4) with 1% BSA, 0.02% Proclin300 and 50% Glycerol.
保存條件 Shipped at 4℃. Store at -20℃ for one year. Avoid repeated freeze/thaw cycles.
注意事項 This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
PubMed PubMed
產品介紹 The product of this gene is a membrane protein expressed on the oligodendrocyte cell surface and the outermost surface of myelin sheaths. Due to this localization, it is a primary target antigen involved in immune-mediated demyelination. This protein may be involved in completion and maintenance of the myelin sheath and in cell-cell communication. Alternatively spliced transcript variants encoding different isoforms have been identified. [provided by RefSeq, Jul 2008]

Function:
Mediates homophilic cell-cell adhesion. Minor component of the myelin sheath. May be involved in completion and/or maintenance of the myelin sheath and in cell-cell communication.

Subunit:
Homodimer. May form heterodimers between the different isoforms.

Subcellular Location:
Cell membrane; Multi-pass membrane protein (Potential).

Tissue Specificity:
Found exclusively in the CNS, where it is localized on the surface of myelin and oligodendrocyte cytoplasmic membranes.

DISEASE:
Defects in MOG are the cause of narcolepsy type 7 (NRCLP7) [MIM:614250]. Neurological disabling sleep disorder, characterized by excessive daytime sleepiness, sleep fragmentation, symptoms of abnormal rapid-eye-movement (REM) sleep, cataplexy, hypnagogic hallucinations, and sleep paralysis. Cataplexy is a sudden loss of muscle tone triggered by emotions, which is the most valuable clinical feature used to diagnose narcolepsy. Human narcolepsy is primarily a sporadically occurring disorder but familial clustering has been observed.

Similarity:
Belongs to the immunoglobulin superfamily. BTN/MOG family.
Contains 1 Ig-like V-type (immunoglobulin-like) domain.

SWISS:
Q61885

Gene ID:
17441

Database links:

Entrez Gene: 4340 Human

Entrez Gene: 17441 Mouse

Entrez Gene: 24558 Rat

Omim: 159465 Human

SwissProt: Q16653 Human

SwissProt: Q61885 Mouse

SwissProt: Q63345 Rat

Unigene: 141308 Human

Unigene: 210857 Mouse

Unigene: 9687 Rat



產品圖片
Sample: Cerebrum (Mouse) Lysate at 40 ug Primary: Anti- Myelin-oligodendrocyte glycoprotein (bs-0426R) at 1/300 dilution Secondary: IRDye800CW Goat Anti-Rabbit IgG at 1/20000 dilution Predicted band size: 24 kD Observed band size: 26 kD
Sample: Cerebrum (Rat) Lysate at 40 ug Primary: Anti- Myelin-oligodendrocyte glycoprotein (bs-0426R) at 1/300 dilution Secondary: IRDye800CW Goat Anti-Rabbit IgG at 1/20000 dilution Predicted band size: 24 kD Observed band size: 26 kD
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