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Nogo B Rabbit pAb (bs-1315R)  
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產品編號 bs-1315R
英文名稱 Nogo B Rabbit pAb
中文名稱 軸索過度生長抑制因子B抗體
別    名 reticulon-4 isoform B; RTN4; RTN4-B1; Nbla10545; RTN-X; reticulon-4A; Nogo-C; NSP; RTN-x; ASY; foocen; NSP-CL; NOGOC; RTN4-A; Reticulon-4; Nbla00271; KIAA0886; NOGOA; Reticulon-5; Foocen; NI220/250; RTN4-C; RTN4-B2; SP1507; NOGO-A; NOGOB; Nogo-B; Nogo-B/A.  
研究領域 神經生物學  Alzheimer's  
抗體來源 Rabbit
克隆類型 Polyclonal
克 隆 號
交叉反應 Human,Mouse,Rat (predicted: Sheep,Dog)
產品應用 WB=1:500-2000
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
理論分子量 39 kDa
檢測分子量
細胞定位 細胞漿 細胞膜 
性    狀 Liquid
濃    度 1mg/ml
免 疫 原 KLH conjugated synthetic peptide derived from human RTN4 isoform B: 251-357/357 
亞    型 IgG
純化方法 affinity purified by Protein A
緩 沖 液 0.01M TBS (pH7.4) with 1% BSA, 0.02% Proclin300 and 50% Glycerol.
保存條件 Shipped at 4℃. Store at -20℃ for one year. Avoid repeated freeze/thaw cycles.
注意事項 This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
PubMed PubMed
產品介紹 This gene belongs to the family of reticulon encoding genes. Reticulons are associated with the endoplasmic reticulum, and are involved in neuroendocrine secretion or in membrane trafficking in neuroendocrine cells. The product of this gene is a potent neurite outgrowth inhibitor which may also help block the regeneration of the central nervous system in higher vertebrates. Alternatively spliced transcript variants derived both from differential splicing and differential promoter usage and encoding different isoforms have been identified.

Function:
NOGO is a potent neurite outgrowth inhibitor which may also help block the regeneration of the central nervous system in higher vertebrates. Adult mammalian axon regeneration is generally successful in the peripheral nervous system but poor in the central nervous system. Inhibition results from physical barriers imposed by glial scars, a lack of neurotrophic factors, and growth-inhibitory molecules associated with myelin, the insulating axon sheath. These molecules include NI35, myelin-associated glycoprotein (159460), and Nogo. Several isoforms (A-E) of NOGO exist.

Subcellular Location:
Endoplasmic reticulum; endoplasmic reticulum membrane; multi-pass membrane protein. Note=Anchored to the membrane of the endoplasmic reticulum through 2 putative transmembrane domains.

SWISS:
Q9NQC3

Gene ID:
57142

Database links:

Entrez Gene: 57142 Human

Entrez Gene: 68585 Mouse

Entrez Gene: 83765 Rat

Omim: 604475 Human

SwissProt: Q9NQC3 Human

SwissProt: Q99P72 Mouse

SwissProt: Q9JK11 Rat

Unigene: 704007 Human



神經生物學相關蛋白(Neurobiology)
Nogo-B蛋白是一組參與組織損傷后再生的跨膜功能蛋白,其中Nogo-B位于多種組織器官中而發揮不同的功能。目前研究發現,Nogo-B與腫瘤抑制、凋亡、神經系統再生抑制、血管內膜損傷修復等多種病理生理過程有不同程度的關系.
產品圖片
Sample: Lane 1: Cerebellum (Mouse) Lysate at 40 ug Lane 2: Cerebellum (Rat) Lysate at 40 ug Primary: Anti-Nogo B (bs-1315R) at 1/1000 dilution Secondary: IRDye800CW Goat Anti-Rabbit IgG at 1/20000 dilution Predicted band size: 44 kD Observed band size: 45 kD
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