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TNFRSF12A/CD266 Rabbit pAb (bs-2493R)  
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50ul/1180.00元
100ul/1980.00元
200ul/2800.00元
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產品編號 bs-2493R
英文名稱 TNFRSF12A/CD266 Rabbit pAb
中文名稱 腫瘤壞死因子配體超家族成員12A(CD266)抗體
別    名 CD 266; CD266; CD266 antigen; TWEAKR; FGF inducible 14; FGF-inducible 14; Fibroblast growth factor inducible immediate early response protein 14; Fibroblast growth factor-inducible immediate-early response protein 14; FN 14; FN14; TNFRSF 12A; TNR12_HUMAN; Tumor necrosis factor receptor superfamily member 12A; TWEAK R; Tweak receptor; Tweak-receptor; TweakR; Type I transmembrane protein Fn 14; Type I transmembrane protein Fn14.  
Specific References  (1)     |     bs-2493R has been referenced in 1 publications.
[IF=4.26] Connolly et al. Cross-species transcriptional analysis reveals conserved and host-specific neoplastic processes in mammalian glioma. (2018) Sci.Rep. 8:1180  IF(IHC-P) ;  Mouse, Rat.  
研究領域 腫瘤  心血管  細胞生物  免疫學  信號轉導  生長因子和激素  細胞膜受體  
抗體來源 Rabbit
克隆類型 Polyclonal
克 隆 號
交叉反應 Human (predicted: Mouse,Rat,Pig,Dog,Horse)
產品應用 ELISA=1:5000-10000
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
理論分子量 11 kDa
檢測分子量
細胞定位 細胞漿 細胞膜 
性    狀 Liquid
濃    度 1mg/ml
免 疫 原 KLH conjugated synthetic peptide derived from human TNFRSF12A: 61-129/129 <Cytoplasmic>
亞    型 IgG
純化方法 affinity purified by Protein A
緩 沖 液 0.01M TBS (pH7.4) with 1% BSA, 0.02% Proclin300 and 50% Glycerol.
保存條件 Shipped at 4℃. Store at -20℃ for one year. Avoid repeated freeze/thaw cycles.
注意事項 This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
PubMed PubMed
產品介紹 TWEAK (otherwise known as TNFRSF12A, Tumor necrosis factor receptor superfamily member 12A), is a member of the TNF family and was first described as a weak inducer of apoptosis in some cell types. It is thought to promote angiogenesis and the proliferation of endothelial cells as well as modulating cellular adhesion to matrix proteins. Recently, a receptor for TWEAK was isolated by expression cloning from a HUVEC cell cDNA library.

Function:
Receptor for TNFSF12/TWEAK. Weak inducer of apoptosis in some cell types. Promotes angiogenesis and the proliferation of endothelial cells. May modulate cellular adhesion to matrix proteins.

Subunit:
Associates with TRAF1 and TRAF2, and probably also with TRAF3.

Subcellular Location:
Membrane; Single-pass type I membrane protein.

Tissue Specificity:
Highly expressed in heart, placenta and kidney. Intermediate expression in lung, skeletal muscle and pancreas.

Similarity:
Contains 1 TNFR-Cys repeat.

SWISS:
Q9NP84

Gene ID:
51330

Database links:

Entrez Gene: 51330 Human

Entrez Gene: 27279 Mouse

Entrez Gene: 302965 Rat

Omim: 605914 Human

SwissProt: Q9NP84 Human

SwissProt: Q9CR75 Mouse

Unigene: 355899 Human

Unigene: 28518 Mouse

Unigene: 105040 Rat



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