麻豆av资源_日本三级一区_www.狠狠艹_国产精妇在线观看第一区_成人性生交大片免费看中国A片_日本一本久久

掃碼關注公眾號           掃碼咨詢技術支持           掃碼咨詢技術服務
  
客服熱線:400-901-9800  客服QQ:4009019800  技術答疑  技術支持  質量反饋  關于我們  聯系我們
91国偷自产一区二区三区蜜臀,亚洲xxxx3d,亚洲肉感在线
首頁 > 產品中心 > 一抗 > 產品信息
CLEC5A Rabbit pAb (bs-2663R)  
訂購熱線:400-901-9800
訂購郵箱:sales@bioss.com.cn
訂購QQ:  400-901-9800
技術支持:techsupport@bioss.com.cn
50ul/1180.00元
100ul/1980.00元
200ul/2800.00元
大包裝/詢價

產品編號 bs-2663R
英文名稱 CLEC5A Rabbit pAb
中文名稱 C型凝集素結構域家族5成員A抗體
別    名 A1 catalytic; A2 catalytic; Alkali myosin light chain 1; Alkali myosin light chain 3; C36E6.3; CMH10; DKFZp779C0562; KMLC; MLC 2; MLC 2v; MLC; MLC1F; MLC2; MLC3F; C-type lectin domain family 5 member A; C type lectin domain family 5 member A; C-type lectin superfamily member 5; CLEC5 A; CLEC5A; CLECSF 5; CLECSF5; MDL 1; MDL-1; MDL1; CLC5A_MOUSE; Myeloid DAP12-associating lectin 1; Myeloid DAP12 associating lectin.  
Specific References  (1)     |     bs-2663R has been referenced in 1 publications.
[IF=4.681] Tong L et al. CLEC5A expressed on myeloid cells as a M2 biomarker relates to immunosuppression and decreased survival in patients with glioma. Cancer Gene Ther. 2019 Oct 8.  IHC-P,IHF&WB ;  Human.  
研究領域 免疫學  微生物學  細菌及病毒  
抗體來源 Rabbit
克隆類型 Polyclonal
克 隆 號
交叉反應 Human,Mouse,Rat (predicted: Rabbit,Pig,Cow,Horse)
產品應用 WB=1:500-2000,IHC-P=1:100-500,IHC-F=1:100-500,IF=1:100-500
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
理論分子量 22 kDa
檢測分子量
細胞定位 細胞膜 
性    狀 Liquid
濃    度 1mg/ml
免 疫 原 KLH conjugated synthetic peptide derived from mouse CLEC5A: 101-190/190 <Extracellular>
亞    型 IgG
純化方法 affinity purified by Protein A
緩 沖 液 0.01M TBS (pH7.4) with 1% BSA, 0.02% Proclin300 and 50% Glycerol.
保存條件 Shipped at 4℃. Store at -20℃ for one year. Avoid repeated freeze/thaw cycles.
注意事項 This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
PubMed PubMed
產品介紹 This gene encodes a member of the C-type lectin/C-type lectin-like domain (CTL/CTLD) superfamily. Members of this family share a common protein fold and have diverse functions, such as cell adhesion, cell-cell signalling, glycoprotein turnover, and roles in inflammation and immune response. The encoded type II transmembrane protein interacts with dnax-activation protein 12 and may play a role in cell activation. Alternative splice variants have been described but their full-length sequence has not been determined. [provided by RefSeq].

Function:
Functions as a positive regulator of osteoclastogenesis. Cell surface receptor that signals via TYROBP. Regulates inflammatory responses. Acts as a key regulator of synovial injury and bone erosion during autoimmune joint inflammation. Critical macrophage receptor for dengue virus serotypes 1-4. The binding of dengue virus to CLEC5A triggers signaling through phosphylation of TYROBP, this interaction does not result in viral entry but stimulates proinflammatory cytokine release.

Subunit:
Monomer. Homodimer. The majority of CLEC5A is expressed as a monomeric form on macrophages. Interacts with TYROBP/DAP12. The interaction with TYROBP is required for CLEC5 cell surface expression. Interacts with HCST/DAP10. Forms an CLEC5A/TYROBP/HCST trimolecular complex depending almost solely on TYROBP.

Subcellular Location:
Cell membrane; Single-pass type II membrane protein.

Tissue Specificity:
Expressed in peripheral blood monocytes and in the monocyte/macrophage cell lines U937 and MonoMac6, but not in cell lines of other origins. Expression is down-regulated when monocytes differentiate into dendritic cells.

Post-translational modifications:
N-glycosylated. Contains sialic acid residues.

DISEASE:
Note=Involved in the pathogenetic mechanisms of Japanese encephalitis virus (JEV) infection of the brain. JEV infection of young mice results in increased expression of CLEC5A in spleen and brain with consequent activation of proinflammatory cytokines secretion.

Similarity:
Contains 1 C-type lectin domain.

SWISS:
Q9R007

Gene ID:
23845

Database links:

Entrez Gene: 23601 Human

Entrez Gene: 23845 Mouse

Entrez Gene: 679787 Rat

Omim: 604987 Human

SwissProt: Q9NY25 Human

SwissProt: Q9R007 Mouse

Unigene: 446235 Human

Unigene: 103765 Mouse

Unigene: 218435 Rat



產品圖片
Sample: Spleen (Mouse) Lysate at 40 ug Primary: Anti-CLEC5A(bs-2663R) at 1/300 dilution Secondary: IRDye800CW Goat Anti-Rabbit IgG at 1/20000 dilution Predicted band size: 22 kD Observed band size: 22 kD
Sample: Lane 1: Mouse Spinal cord tissue lysates Lane 2: Rat Spinal cord tissue lysates Primary: Anti-CLEC5A (bs-2663R) at 1/1000 dilution Secondary: IRDye800CW Goat Anti-Rabbit IgG at 1/20000 dilution Predicted band size: 22 kDa Observed band size: 37 kDa
Paraformaldehyde-fixed, paraffin embedded (human gastric carcinoma); Antigen retrieval by boiling in sodium citrate buffer (pH6.0) for 15min; Block endogenous peroxidase by 3% hydrogen peroxide for 20 minutes; Blocking buffer (normal goat serum) at 37°C for 30min; Antibody incubation with (CLEC5A) Polyclonal Antibody, Unconjugated (bs-2663R) at 1:200 overnight at 4°C, followed by operating according to SP Kit(Rabbit) (sp-0023) instructionsand DAB staining.
Tissue/cell: human colon carcinoma; 4% Paraformaldehyde-fixed and paraffin-embedded; Antigen retrieval: citrate buffer ( 0.01M, pH 6.0 ), Boiling bathing for 15min; Block endogenous peroxidase by 3% Hydrogen peroxide for 30min; Blocking buffer (normal goat serum,C-0005) at 37℃ for 20 min; Incubation: Anti-CLEC5A/MDL1 Polyclonal Antibody, Unconjugated(bs-2663R) 1:200, overnight at 4°C, followed by conjugation to the secondary antibody(SP-0023) and DAB(C-0010) staining
版權所有 2004-2026 m.jywcc.com 北京博奧森生物技術有限公司
通過國際質量管理體系ISO 9001:2015 GB/T 19001-2016    證書編號: 00124Q34771R2M/1100
通過國際醫療器械-質量管理體系ISO 13485:2016 GB/T 42061-2022    證書編號: CQC24QY10047R0M/1100
京ICP備05066980號-1         京公網安備110107000727號
主站蜘蛛池模板: 国产极品在线观看 | 东方aⅴ免费观看久久av | 一个人看的视频www在线观看 | 久久精品亚洲女星A级视频 邻居少妇张开双腿让我爽一夜 | 丰满熟妇人妻中文字幕 | 亚洲美女一区 | 亚洲日韩AV无码中文字幕美国 | 狠狠躁夜夜躁人人爽天天不卡软件 | 阿拉伯一级黄色片 | 在线日本欧美 | 特黄特色大片免费播放 | 一本大道区一区二区三乱码八 | 国产精品秘入口A级一区二区 | 亚洲第一中文字幕 | 国产精品无码av片在线观看播放 | 狠狠色噜噜狠狠狠狠aV不卡 | 性爱无码视频在线看 | 国产肥熟老胖女在线看 | 国产真实农村乱对白精彩 | 国产一区二区三区精彩视频 | 精品黑人一区二区三区 | 国产亚洲精品久 | 一级片国语 | 无码人妻少妇久久中文字幕蜜桃 | 欧美人与禽猛交狂配 | 国产免费一区二区三区不卡不 | 亚洲欧美日韩国产精品一区二区 | 精品在线视频亚洲 | 一本大道区一区二区三乱码八 | 一级特黄bbbbb免费观看 | 91视频18 | 草草国产| 亚洲日本在线观看 | 成人国产精品免费 | 妇女一级片 | 四虎影视国产在线视频 | 亚洲AV成人中文无码专区 | 奇米影视7777狠狠狠狠色 | 久草色播 | 久久精品国产99精品国产2021 | 97久久国产|