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Apelin Receptor Rabbit pAb (bs-2430R)  
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產品編號 bs-2430R
英文名稱 Apelin Receptor Rabbit pAb
中文名稱 血管緊張素II受體樣蛋白1抗體
別    名 APJ receptor; AGTR L1; AGTRL 1; AGTRL1; Angiotensin II receptor like 1; Angiotensin receptor like 1; Apelin receptor; APJ; B78; FLJ90771; G protein coupled receptor APJ; GPCR34; HG 11; HG11; MGC45246; MSR; msr/apj; Aplnr; Agtrl1; APLNR; FLJ96609; APJ_HUMAN.  
Specific References  (4)     |     bs-2430R has been referenced in 4 publications.
[IF=3.968] Bingyuan Ji et al. Roles for heterodimerization of APJ and B2R in promoting cell proliferation via ERK1/2-eNOS signaling pathway. Cell Signal. 2020 Sep;73:109671.  co-IP ;  Human.  
[IF=2.976] Cemre Nur Balci. et al. The investigation of apelin and apelin receptor expressions in mouse endometrium during peri-implantation period. ANN ANAT. 2023 Feb;246:152027  WB, IHC ;  Mouse.  
[IF=1.64] Izgüt-Uysal, V. N., et al. "The effect of apelin on the functions of peritoneal macrophages." Physiological research (2017).  IHC ;  Rat.  
[IF=1.61] Ustunel, Ismail, et al. "The effects of water immersion and restraint stress on the expressions of apelin, apelin receptor (APJR) and apoptosis rate in the rat heart." Acta Histochemica (2014)  IHC-P ;  Rat.  
研究領域 心血管  細胞生物  免疫學  G蛋白偶聯受體  G蛋白信號  
抗體來源 Rabbit
克隆類型 Polyclonal
克 隆 號
交叉反應 Mouse
產品應用 WB=1:500-2000
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
理論分子量 42 kDa
檢測分子量
細胞定位 細胞膜 
性    狀 Liquid
濃    度 1mg/ml
免 疫 原 KLH conjugated synthetic peptide derived from human Apelin receptor: 41-140/380 <Cytoplasmic>
亞    型 IgG
純化方法 affinity purified by Protein A
緩 沖 液 0.01M TBS (pH7.4) with 1% BSA, 0.02% Proclin300 and 50% Glycerol.
保存條件 Shipped at 4℃. Store at -20℃ for one year. Avoid repeated freeze/thaw cycles.
注意事項 This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
PubMed PubMed
產品介紹 This gene encodes a member of the G protein-coupled receptor gene family. The encoded protein is related to the angiotensin receptor, but is actually an apelin receptor that inhibits adenylate cyclase activity and plays a counter-regulatory role against the pressure action of angiotensin II by exerting hypertensive effect. It functions in the cardiovascular and central nervous systems, in glucose metabolism, in embryonic and tumor angiogenesis and as a human immunodeficiency virus (HIV-1) coreceptor. Two transcript variants resulting from alternative splicing have been identified. [provided by RefSeq

Function:
Receptor for apelin coupled to G proteins that inhibit adenylate cyclase activity. Alternative coreceptor with CD4 for HIV-1 infection; may be involved in the development of AIDS dementia.

Subcellular Location:
Cell membrane.

Tissue Specificity:
Widely expressed in the brain, in glial cells, astrocytes and neuronal subpopulations, as well as in the spleen, thymus, ovary, small intestine and colon.

Similarity:
Belongs to the G-protein coupled receptor 1 family.

SWISS:
P35414

Gene ID:
187

Database links:

Entrez Gene: 429337 Chicken

Entrez Gene: 615435 Cow

Entrez Gene: 187 Human

Entrez Gene: 23796 Mouse

Entrez Gene: 83518 Rat

Omim: 600052 Human

SwissProt: P35414 Human

SwissProt: Q9WV08 Mouse

SwissProt: Q9JHG3 Rat

Unigene: 438311 Human

Unigene: 29368 Mouse

Unigene: 7965 Rat



產品圖片
25 ug total protein per lane of various lysates (see on figure) probed with Apelin Receptor polyclonal antibody, unconjugated (bs-2430R) at 1:1000 dilution and 4°C overnight incubation. Followed by conjugated secondary antibody incubation at r.t. for 60 min.
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