麻豆av资源_日本三级一区_www.狠狠艹_国产精妇在线观看第一区_成人性生交大片免费看中国A片_日本一本久久

掃碼關注公眾號           掃碼咨詢技術支持           掃碼咨詢技術服務
  
客服熱線:400-901-9800  客服QQ:4009019800  技術答疑  技術支持  質量反饋  關于我們  聯系我們
久草中文在线视频,欧美国产视频,国产精品女主播一区二区三区
首頁 > 產品中心 > 一抗 > 產品信息
TNFSF14 Rabbit pAb (bs-2462R)  
訂購熱線:400-901-9800
訂購郵箱:sales@bioss.com.cn
訂購QQ:  400-901-9800
技術支持:techsupport@bioss.com.cn
50ul/1180.00元
100ul/1980.00元
200ul/2800.00元
大包裝/詢價

產品編號 bs-2462R
英文名稱 TNFSF14 Rabbit pAb
中文名稱 腫瘤壞死因子配體超家族成員14抗體
別    名 Tumor necrosis factor ligand superfamily member 14; CD 258; CD258; CD258 antigen; delta transmembrane LIGHT; Herpes virus entry mediator ligand; Herpesvirus entry mediator A; Herpesvirus entry mediator ligand; herpesvirus entry mediator-ligand; HVEM L; HVEM-L; HVEML; Ligand for herpesvirus entry mediator; LIGHT; LTg; soluble form; TNF14; TNFSF 14; TNFSF14 protein; TR 2; TR2; Tumor necrosis factor(ligand) superfamily, member 14; Tumor necrosis factor ligand superfamily, member 14; Tumor necrosis factor receptor like 2; Tumor necrosis factor superfamily member LIGHT; TNF14_HUMAN.  
Specific References  (1)     |     bs-2462R has been referenced in 1 publications.
[IF=4.486] Yu Zhong. et al. LIGHT aggravates sepsis‐associated acute kidney injury via TLR4‐MyD88‐NF‐κB pathway. J Cell Mol Med. 2020 Oct;24(20):11936-11948  IF ;  Human.  
研究領域 細胞生物  t-淋巴細胞  細胞因子  
抗體來源 Rabbit
克隆類型 Polyclonal
克 隆 號
交叉反應 Human,Mouse (predicted: Rat)
產品應用 WB=1:500-2000,ELISA=1:500-5000
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
理論分子量 26 kDa
檢測分子量
細胞定位 細胞漿 細胞膜 分泌型蛋白 
性    狀 Liquid
濃    度 1mg/ml
免 疫 原 KLH conjugated synthetic peptide derived from human TNFSF14: 141-240/240 <Extracellular>
亞    型 IgG
純化方法 affinity purified by Protein A
緩 沖 液 0.01M TBS (pH7.4) with 1% BSA, 0.02% Proclin300 and 50% Glycerol.
保存條件 Shipped at 4℃. Store at -20℃ for one year. Avoid repeated freeze/thaw cycles.
注意事項 This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
PubMed PubMed
產品介紹 LIGHT protein is a type II transmembrane protein and a tumor necrosis factor (TNF) ligand superfamily member (TNFSF14). LIGHT is expressed on activated T cells and immature dendritic cells and its receptors have been identified as lymphotoxin-Beta receptor (LTBetaR) and the herpesvirus entry mediator (HVEM), both of which lack the cytoplasmic sequence termed as "death domain." LIGHT is first identified as HVEM ligand (HVEM-L) and a deterrent to herpesvirus infection according to its ability to compete with HSV glycoprotein D for HVEM binding. As a T cell-derived costimulatory ligand, TNFSF14 plays a crucial role in T cell activation and proliferation by LIGHT-LTBetaR interaction, and it is necessary and sufficient for LIGHT-mediated apoptosis of tumor cells. Additionally, recent studies also establish a direct role for LIGHT in NK activation/expansion via LIGHT-HVEM interaction, and thus breaking T-cell tolerance at the tumor site. Accordingly, LIGHT is suggested to be involved in CTL-mediated tumor rejection, allograft rejection and graft versus host disease. Although known as lymphotoxin-Gamma, LIGHT plays a minimal role in lymphoid tissue development in contrast with LT-Alpha and Beta. This protein was also demonstrated to inhibit TNF-Alpha-mediated but not Fas- or TRAIL-mediated apoptosis of human primary hepatocytes.

Function:
Cytokine that binds to TNFRSF3/LTBR. Binding to the decoy receptor TNFRSF6B modulates its effects. Activates NFKB, stimulates the proliferation of T-cells, and inhibits growth of the adenocarcinoma HT-29. Acts as a receptor for Herpes simplex virus.

Subunit:
Homotrimer.

Subcellular Location:
Tumor necrosis factor ligand superfamily member 14, membrane form: Cell membrane; Single-pass type II membrane protein.
Tumor necrosis factor ligand superfamily member 14, soluble form: Secreted.
Isoform 2: Cytoplasm.

Tissue Specificity:
Predominantly expressed in the spleen but also found in the brain. Weakly expressed in peripheral lymphoid tissues and in heart, placenta, liver, lung, appendix, and kidney, and no expression seen in fetal tissues, endocrine glands, or nonhematopoietic tumor lines.

Post-translational modifications:
N-glycosylated.
The soluble form of isoform 1 derives from the membrane form by proteolytic processing.

Similarity:
Belongs to the tumor necrosis factor family.

SWISS:
O43557

Gene ID:
8740

Database links:

Entrez Gene: 8740 Human

Omim: 604520 Human

SwissProt: O43557 Human

Unigene: 129708 Human



產品圖片
Sample: Spleen (Mouse) Lysate at 40 ug Small intestine (Mouse) Lysate at 40 ug Primary: Anti-TNFSF14 (bs-2462R) at 1/1000 dilution Secondary: IRDye800CW Goat Anti-Rabbit IgG at 1/20000 dilution Predicted band size: 26 kD Observed band size: 26 kD
版權所有 2004-2026 m.jywcc.com 北京博奧森生物技術有限公司
通過國際質量管理體系ISO 9001:2015 GB/T 19001-2016    證書編號: 00124Q34771R2M/1100
通過國際醫療器械-質量管理體系ISO 13485:2016 GB/T 42061-2022    證書編號: CQC24QY10047R0M/1100
京ICP備05066980號-1         京公網安備110107000727號
主站蜘蛛池模板: 亚洲欧美精品一区二区 | 亚洲精品无码MV在线观看软件 | 麻豆视传媒在线观看 | 色欲AV久久一区二区三区 | 欧美国产日韩在线视频 | 欧美一级特黄特色大片免费 | gogogo免费高清在线中国 | 日韩第一视频 | 日精品一区二区三区 | 中国久久精品 | 97久久国产 | 青青草原亚洲 | AV淘宝国产在线观看 | 两根一起进三P免费视频 | 色一区二区三区 | 欧美—级在线免费片 | 成人国产精品一区二区网站 | 国产精一品亚洲二区在线视频 | 99er在线观看视频 | 国产91色在线亚洲 | 四虎在线影院 | 亚洲一级大片 | 久久久久爽人综合网站 | 国内一级黄色 | www久久九 | 免费A级毛片无码免费视频首页 | 无码毛片视频一区二区本码 | 高清毛茸茸的中国少妇 | 亚洲欧洲成人A∨在线观看 9797色 | 亚洲九九九九 | 少妇高潮毛片免费看A片 | 含羞草亚洲AV无码久久精品 | 欧美人与动牲交片免费播放 | 欧日av| 成人乱淫av日日摸夜夜爽节目 | 福利片免费在线观看 | 亚洲中文欧美日韩在线观看 | 欧美熟妇XXXXX欧美老妇不卡 | 日本伊人精品一区二区三区 | 东北老女人高潮疯狂过瘾对白 | jizzjizz丝袜老师 |