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CD244 Rabbit pAb (bs-2470R)  
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產品編號 bs-2470R
英文名稱 CD244 Rabbit pAb
中文名稱 CD244抗體
別    名 NKR2B4; SLAMF4; natural killer cell receptor 2B4 isoform 2 precursor; 2B4; C9.1; CD244 antigen; CD244 molecule natural killer cell receptor 2B4; CD244 natural killer cell receptor 2B4; F730046O15Rik; h2B4; Ly90; NAIL; Natural killer cell activation-inducing ligand; Natural killer cell receptor 2B4; NK cell activation inducing ligand; NK cell activation inducing ligand NAIL; NK cell type I receptor protein 2B4; Nmrk; Non-MHC restricted killing associated; OTTHUMP00000027884; p38; SLAM family, member 4.  
Specific References  (2)     |     bs-2470R has been referenced in 2 publications.
[IF=6.66] Peiffer, Daniel S., et al. "Dietary consumption of black raspberries or their anthocyanin constituents alters innate immune cell trafficking in esophageal cancer." Cancer immunology research 4.1 (2016): 72-82.  IHC-P ;  Rat.  
[IF=4.047] Xu Xiaoyan. et al. A novel 2B4 receptor leads to worse pregnancy outcomes by facilitating TNF-α and IFN-γ production in dNK cells during Toxoplasma gondii infection. PARASITE VECTOR. 2022 Dec;15(1):1-15  WB ;  Human.  
研究領域 細胞生物  免疫學  干細胞  細胞粘附分子  細胞表面分子  自然殺傷細胞  淋巴細胞  t-淋巴細胞  
抗體來源 Rabbit
克隆類型 Polyclonal
克 隆 號
交叉反應 Human,Rat (predicted: Mouse)
產品應用 WB=1:500-2000
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
理論分子量 42 kDa
檢測分子量
細胞定位 細胞膜 
性    狀 Liquid
濃    度 1mg/ml
免 疫 原 KLH conjugated synthetic peptide derived from human CD244: 151-250/370 <Extracellular>
亞    型 IgG
純化方法 affinity purified by Protein A
緩 沖 液 0.01M TBS (pH7.4) with 1% BSA, 0.02% Proclin300 and 50% Glycerol.
保存條件 Shipped at 4℃. Store at -20℃ for one year. Avoid repeated freeze/thaw cycles.
注意事項 This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
PubMed PubMed
產品介紹 This gene encodes a cell surface receptor expressed on natural killer (NK) cells (and some T cells) that mediate non-major histocompatibility complex (MHC) restricted killing. The interaction between NK-cell and target cells via this receptor is thought to modulate NK-cell cytolytic activity. Alternatively spliced transcript variants encoding different isoforms have been found for this gene.[provided by RefSeq, Oct 2009]

Function:
Modulate other receptor-ligand interactions to enhance leukocyte activation.

Subunit:
Interacts with CD48. Following phosphorylation, it is able to recruit PTPN11/SHP-2 and SH2D1A/SAP. Binding of SH2D1A/SAP to CD244 prevents its association with PTPN11/SHP-2.

Subcellular Location:
Membrane; Single-pass type I membrane protein (Potential).

Tissue Specificity:
Expressed in spleen, PBL, followed by lung, liver, testis and small intestine. Expressed not only in NK cells, but also on monocytes and basophils.

Similarity:
Contains 2 Ig-like (immunoglobulin-like) domains.

SWISS:
Q9BZW8

Gene ID:
51744

Database links:

Entrez Gene: 51744 Human

Entrez Gene: 18106 Mouse

Entrez Gene: 64025 Rat

Omim: 605554 Human

SwissProt: Q9BZW8 Human

SwissProt: Q07763 Mouse

SwissProt: Q9JLM2 Rat

Unigene: 157872 Human

Unigene: 2299 Mouse

Unigene: 113760 Rat

Unigene: 53994 Rat



產品圖片
Sample: Lane 1: Rat Thymus tissue lysates Lane 2: Rat Lymph node tissue lysates Lane 3: Human Serum Primary: Anti-CD244 (bs-2470R) at 1/1000 dilution Secondary: IRDye800CW Goat Anti-Rabbit IgG at 1/20000 dilution Predicted band size:42 kD Observed band size:70 kD
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