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SIGLEC10 Rabbit pAb (bs-2706R)  
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50ul/1180.00元
100ul/1980.00元
大包裝/詢價

產(chǎn)品編號 bs-2706R
英文名稱 SIGLEC10 Rabbit pAb
中文名稱 唾液酸結(jié)合性免疫球蛋白樣凝集素抗體
別    名 SIG10_HUMAN; Sialic acid-binding Ig-like lectin 10; SLG2; Siglec-10; Siglec-like protein 2; UNQ477/PRO940; sialic acid binding Ig like lectin 10;  
Specific References  (1)     |     bs-2706R has been referenced in 1 publications.
[IF=7.666] Xiao Han. et al. Pyrotinib Targeted EGFR-STAT3/CD24 Loop-Mediated Cell Viability in TSC. CELLS-BASEL. 2022 Jan;11(19):3064  WB ;  Mouse.  
研究領(lǐng)域 細(xì)胞生物  免疫學(xué)  自然殺傷細(xì)胞  
抗體來源 Rabbit
克隆類型 Polyclonal
克 隆 號
交叉反應(yīng) Human,Mouse,Rat
產(chǎn)品應(yīng)用 WB=1:500-2000,ELISA=1:5000-10000
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
理論分子量 77 kDa
檢測分子量
細(xì)胞定位 細(xì)胞膜 分泌型蛋白 
性    狀 Liquid
濃    度 1mg/ml
免 疫 原 KLH conjugated synthetic peptide derived from human SIGLEC10 <Extracellular>
亞    型 IgG
純化方法 affinity purified by Protein A
緩 沖 液 0.01M TBS (pH7.4) with 1% BSA, 0.02% Proclin300 and 50% Glycerol.
保存條件 Shipped at 4℃. Store at -20℃ for one year. Avoid repeated freeze/thaw cycles.
注意事項 This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
PubMed PubMed
產(chǎn)品介紹 SIGLECs are members of the immunoglobulin superfamily that are expressed on the cell surface. Most SIGLECs have 1 or more cytoplasmic immune receptor tyrosine-based inhibitory motifs, or ITIMs. SIGLECs are typically expressed on cells of the innate immune system, with the exception of the B-cell expressed SIGLEC6 (MIM 604405).[supplied by OMIM, Jul 2002]

Function:
Putative adhesion molecule that mediates sialic-acid dependent binding to cells. Preferentially binds to alpha-2,3- or alpha-2,6-linked sialic acid. The sialic acid recognition site may be masked by cis interactions with sialic acids on the same cell surface. In the immune response, may act as an inhibitory receptor upon ligand induced tyrosine phosphorylation by recruiting cytoplasmic phosphatase(s) via their SH2 domain(s) that block signal transduction through dephosphorylation of signaling molecules.

Subunit:
Interacts with PTPN6/SHP-1 upon phosphorylation.

Subcellular Location:
Isoform 1, 2, 3, 4: Cell membrane; Single-pass type I membrane protein. Isoform 5: Secreted.

Tissue Specificity:
Expressed by peripheral blood leukocytes (eosinophils, monocytes and a natural killer cell subpopulation). Isoform 5 is found to be the most abundant isoform. Found in lymph node, lung, ovary and appendix. Isoform 1 is found at high levels and isoform 2 at lower levels in bone marrow, spleen and spinal chord. Isoform 2 is also found in brain. Isoform 4 is specifically found in natural killer cells.

Post-translational modifications:
Phosphorylation of Tyr-667 is involved in binding to PTPN6.

Similarity:
Belongs to the immunoglobulin superfamily. SIGLEC (sialic acid binding Ig-like lectin) family.
Contains 3 Ig-like C2-type (immunoglobulin-like) domains.
Contains 1 Ig-like V-type (immunoglobulin-like) domain.

SWISS:
Q96LC7

Gene ID:
89790

Database links:

Entrez Gene: 89790 Human

Omim: 606091 Human

SwissProt: Q96LC7 Human

Unigene: 284813 Human



產(chǎn)品圖片
Sample: Lane 1: Mouse Spleen tissue lysates Lane 2: Mouse Lung tissue lysates Lane 3: Human HL-60 cell lysates Lane 4: Human K562 cell lysates Lane 5: Human Jurkat cell lysates Primary: Anti-SIGLEC10 (bs-2706R) at 1/1000 dilution Secondary: IRDye800CW Goat Anti-Rabbit IgG at 1/20000 dilution Predicted band size: 77 kDa Observed band size: 100 kDa
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