麻豆av资源_日本三级一区_www.狠狠艹_国产精妇在线观看第一区_成人性生交大片免费看中国A片_日本一本久久

掃碼關注公眾號           掃碼咨詢技術支持           掃碼咨詢技術服務
  
客服熱線:400-901-9800  客服QQ:4009019800  技術答疑  技術支持  質量反饋  關于我們  聯系我們
交资源www在线观看,亚洲人成激情在线播放国,欧美人与动牲交a免费
首頁 > 產品中心 > 一抗 > 產品信息
GAB2 Rabbit pAb (bs-2885R)  
訂購熱線:400-901-9800
訂購郵箱:sales@bioss.com.cn
訂購QQ:  400-901-9800
技術支持:techsupport@bioss.com.cn
50ul/1180.00元
100ul/1980.00元
200ul/2800.00元
大包裝/詢價

產品編號 bs-2885R
英文名稱 GAB2 Rabbit pAb
中文名稱 接頭蛋白Gab 2抗體
別    名 GAB 2; Gab2; Grb 2 associated binder 2; GRB 2 associated binding protein 2; Grb2 associated binder 2; GRB2 associated binder 2 pp100; GRB2 associated binding protein 2; Growth factor receptor bound protein 2 associated protein 2; KIAA0571; p97; PH domain containing adaptor molecule p97; pp100; Alternative namesGRB2 associated binder 2 pp100.  
Specific References  (2)     |     bs-2885R has been referenced in 2 publications.
[IF=3.118] Fu S et al. Berberine suppresses mast cell-mediated allergic responses via regulating Fc?RI-mediated and MAPK signaling.Int Immunopharmacol.?2019 Jun;71:1-6.  WB ;  Human.  
[IF=2.31] Zhan, Ao, et al. ?Decreased expression of Gab2 in patients with temporal lobe epilepsy and pilocarpine‐induced rat model.? Synapse (2013).  IHC-P ;  Human.  
研究領域 腫瘤  細胞生物  免疫學  神經生物學  信號轉導  細胞膜受體  Alzheimer's  
抗體來源 Rabbit
克隆類型 Polyclonal
克 隆 號
交叉反應 Human,Mouse,Rat (predicted: Rabbit,Pig,Cow,Dog,Horse)
產品應用 IHC-P=1:100-500,IHC-F=1:100-500,IF=1:50-200,Flow-Cyt=1μg /test
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
理論分子量 74 kDa
檢測分子量
細胞定位 細胞漿 細胞膜 
性    狀 Liquid
濃    度 1mg/ml
免 疫 原 KLH conjugated synthetic peptide derived from human Gab2: 601-676/676 
亞    型 IgG
純化方法 affinity purified by Protein A
緩 沖 液 0.01M TBS (pH7.4) with 1% BSA, 0.02% Proclin300 and 50% Glycerol.
保存條件 Shipped at 4℃. Store at -20℃ for one year. Avoid repeated freeze/thaw cycles.
注意事項 This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
PubMed PubMed
產品介紹 This gene is a member of the GRB2-associated binding protein (GAB) gene family. These proteins contain pleckstrin homology (PH) domain, and bind SHP2 tyrosine phosphatase and GRB2 adapter protein. They act as adapters for transmitting various signals in response to stimuli through cytokine and growth factor receptors, and T- and B-cell antigen receptors. The protein encoded by this gene is the principal activator of phosphatidylinositol-3 kinase in response to activation of the high affinity IgE receptor. Two alternatively spliced transcripts encoding different isoforms have been described for this gene. [provided by RefSeq, Nov 2009]

Function:
Adapter protein which acts downstream of several membrane receptors including cytokine, antigen, hormone, cell matrix and growth factor receptors to regulate multiple signaling pathways. Regulates osteoclast differentiation mediating the TNFRSF11A/RANK signaling. In allergic response, it plays a role in mast cells activation and degranulation through PI-3-kinase regulation. Also involved in the regulation of cell proliferation and hematopoiesis.

Subunit:
Interacts with SHC1; may mediate interaction with receptors. Interacts with SYK. Interacts with PI-3 kinase. Interacts with GRB2 (via SH3 2 domain). Interacts with PTPN11. Interacts with TNFRSF11A (via cytoplasmic domain). Interacts (phosphorylated) with 14-3-3 family proteins SFN, YWHAB, YWHAE, YWHAG, YWHAH, YWHAQ and YWHAZ; prevents interaction with GRB2 and attenuates GAB2 signaling.

Subcellular Location:
Cytoplasm. Cell membrane

Post-translational modifications:
Phosphorylated on tyrosine residue(s) by the thrombopoietin receptor (TPOR), stem cell factor receptor (SCFR), and T-cell and B-cell antigen receptors, gp130, IL-2R and IL-3R. Phosphorylated upon stimulation of TNFRSF11A/RANK by TNFSF11/RANK. Phosphorylated upon EGF stimulation.
Dephosphorylated by PTPN11.

Similarity:
Belongs to the GAB family.
Contains 1 PH domain.

SWISS:
Q9UQC2

Gene ID:
9846

Database links:

Entrez Gene: 9846 Human

Entrez Gene: 14389 Mouse

Entrez Gene: 84477 Rat

Omim: 606203 Human

SwissProt: Q9UQC2 Human

SwissProt: Q9Z1S8 Mouse

SwissProt: Q9EQH1 Rat

Unigene: 429434 Human

Unigene: 42033 Mouse

Unigene: 211990 Rat



產品圖片
Paraformaldehyde-fixed, paraffin embedded (Mouse brain); Antigen retrieval by microwave in sodium citrate buffer (pH6.0) ; Block endogenous peroxidase by 3% hydrogen peroxide for 30 minutes; Blocking buffer (3% BSA) at RT for 30min; Antibody incubation with (GAB2) Polyclonal Antibody, Unconjugated (bs-2885R) at 1:400 overnight at 4℃, followed by conjugation to the secondary antibody (labeled with HRP)and DAB staining.
Paraformaldehyde-fixed, paraffin embedded (Rat brain); Antigen retrieval by microwave in sodium citrate buffer (pH6.0) ; Block endogenous peroxidase by 3% hydrogen peroxide for 30 minutes; Blocking buffer (3% BSA) at RT for 30min; Antibody incubation with (GAB2) Polyclonal Antibody, Unconjugated (bs-2885R) at 1:400 overnight at 4℃, followed by conjugation to the secondary antibody (labeled with HRP)and DAB staining.
Blank control(blue): U-87MG(fixed with 2% paraformaldehyde (10 min) , then permeabilized with 90% ice-cold methanol for 30 min on ice). Primary Antibody:Rabbit Anti-DAB2 antibody(bs-2885R), Dilution: 1μg in 100 μL 1X PBS containing 0.5% BSA; Isotype Control Antibody: Rabbit IgG(orange) ,used under the same conditions ); Secondary Antibody: Goat anti-rabbit IgG-PE(white blue), Dilution: 1:200 in 1 X PBS containing 0.5% BSA.
版權所有 2004-2026 m.jywcc.com 北京博奧森生物技術有限公司
通過國際質量管理體系ISO 9001:2015 GB/T 19001-2016    證書編號: 00124Q34771R2M/1100
通過國際醫療器械-質量管理體系ISO 13485:2016 GB/T 42061-2022    證書編號: CQC24QY10047R0M/1100
京ICP備05066980號-1         京公網安備110107000727號
主站蜘蛛池模板: 中文字幕久久乱码一级毛片 | 在线视频观看免费 | 古装一级裸体片在线观看 | 九九久久精品免费观看 | 中文字幕视频免费在线观看 | 国产高清在线无码自慰 | 免费成人av在线 | 人妻斩り56歳无码 | 91粉色视频 | 一本一道久久久久久久久 | 精品国产一区二区三区麻豆 | 久久久99国产精品免费 | 亚洲精品视频中文字幕 | 欧美一个色资源 | 亚洲第一欧美 | 国产69精品久久久久9999不卡免费 | 玩弄人妻少妇500系列视频 | 黄在线观看免费网站ktv | 亚洲一区二区精品蜜桃 | 日本免费在线视频观看 | 在线欧美一级视频 | 国产黄a三级三级三级av在线看 | 激情黄色一级片 | 1000部夫妻午夜免费 | 国产ktv交换配乱婬视频 | 国产国拍精品av在线观看按摩 | 福利片一区二区 | 免费精品国产va自在自线 | 欧美肉大捧一进一出 | 人妻被修空调在夫面侵犯 | 久久狼人大香伊蕉国产 | 99视频精品免费观看 | 玖爱在线视频 | 久久人人爽人人爽人人片AV东京热 | 亚洲aⅴ综合色区无码一区 日日夜夜91 | 欧美乱性 | 日一级毛片 | 正在播放群交换视频国产 | 五月色丁香婷婷网蜜臀AV | 天堂成人国产精品一区 | 国产精口品美女乱子伦高潮 |