麻豆av资源_日本三级一区_www.狠狠艹_国产精妇在线观看第一区_成人性生交大片免费看中国A片_日本一本久久

掃碼關注公眾號           掃碼咨詢技術支持           掃碼咨詢技術服務
  
客服熱線:400-901-9800  客服QQ:4009019800  技術答疑  技術支持  質量反饋  關于我們  聯系我們
交资源www在线观看,亚洲人成激情在线播放国,欧美人与动牲交a免费
首頁 > 產品中心 > 一抗 > 產品信息
GAB2 Rabbit pAb (bs-2885R)  
訂購熱線:400-901-9800
訂購郵箱:sales@bioss.com.cn
訂購QQ:  400-901-9800
技術支持:techsupport@bioss.com.cn
50ul/1180.00元
100ul/1980.00元
200ul/2800.00元
大包裝/詢價

產品編號 bs-2885R
英文名稱 GAB2 Rabbit pAb
中文名稱 接頭蛋白Gab 2抗體
別    名 GAB 2; Gab2; Grb 2 associated binder 2; GRB 2 associated binding protein 2; Grb2 associated binder 2; GRB2 associated binder 2 pp100; GRB2 associated binding protein 2; Growth factor receptor bound protein 2 associated protein 2; KIAA0571; p97; PH domain containing adaptor molecule p97; pp100; Alternative namesGRB2 associated binder 2 pp100.  
Specific References  (2)     |     bs-2885R has been referenced in 2 publications.
[IF=3.118] Fu S et al. Berberine suppresses mast cell-mediated allergic responses via regulating Fc?RI-mediated and MAPK signaling.Int Immunopharmacol.?2019 Jun;71:1-6.  WB ;  Human.  
[IF=2.31] Zhan, Ao, et al. ?Decreased expression of Gab2 in patients with temporal lobe epilepsy and pilocarpine‐induced rat model.? Synapse (2013).  IHC-P ;  Human.  
研究領域 腫瘤  細胞生物  免疫學  神經生物學  信號轉導  細胞膜受體  Alzheimer's  
抗體來源 Rabbit
克隆類型 Polyclonal
克 隆 號
交叉反應 Human,Mouse,Rat (predicted: Rabbit,Pig,Cow,Dog,Horse)
產品應用 IHC-P=1:100-500,IHC-F=1:100-500,IF=1:50-200,Flow-Cyt=1μg /test
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
理論分子量 74 kDa
檢測分子量
細胞定位 細胞漿 細胞膜 
性    狀 Liquid
濃    度 1mg/ml
免 疫 原 KLH conjugated synthetic peptide derived from human Gab2: 601-676/676 
亞    型 IgG
純化方法 affinity purified by Protein A
緩 沖 液 0.01M TBS (pH7.4) with 1% BSA, 0.02% Proclin300 and 50% Glycerol.
保存條件 Shipped at 4℃. Store at -20℃ for one year. Avoid repeated freeze/thaw cycles.
注意事項 This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
PubMed PubMed
產品介紹 This gene is a member of the GRB2-associated binding protein (GAB) gene family. These proteins contain pleckstrin homology (PH) domain, and bind SHP2 tyrosine phosphatase and GRB2 adapter protein. They act as adapters for transmitting various signals in response to stimuli through cytokine and growth factor receptors, and T- and B-cell antigen receptors. The protein encoded by this gene is the principal activator of phosphatidylinositol-3 kinase in response to activation of the high affinity IgE receptor. Two alternatively spliced transcripts encoding different isoforms have been described for this gene. [provided by RefSeq, Nov 2009]

Function:
Adapter protein which acts downstream of several membrane receptors including cytokine, antigen, hormone, cell matrix and growth factor receptors to regulate multiple signaling pathways. Regulates osteoclast differentiation mediating the TNFRSF11A/RANK signaling. In allergic response, it plays a role in mast cells activation and degranulation through PI-3-kinase regulation. Also involved in the regulation of cell proliferation and hematopoiesis.

Subunit:
Interacts with SHC1; may mediate interaction with receptors. Interacts with SYK. Interacts with PI-3 kinase. Interacts with GRB2 (via SH3 2 domain). Interacts with PTPN11. Interacts with TNFRSF11A (via cytoplasmic domain). Interacts (phosphorylated) with 14-3-3 family proteins SFN, YWHAB, YWHAE, YWHAG, YWHAH, YWHAQ and YWHAZ; prevents interaction with GRB2 and attenuates GAB2 signaling.

Subcellular Location:
Cytoplasm. Cell membrane

Post-translational modifications:
Phosphorylated on tyrosine residue(s) by the thrombopoietin receptor (TPOR), stem cell factor receptor (SCFR), and T-cell and B-cell antigen receptors, gp130, IL-2R and IL-3R. Phosphorylated upon stimulation of TNFRSF11A/RANK by TNFSF11/RANK. Phosphorylated upon EGF stimulation.
Dephosphorylated by PTPN11.

Similarity:
Belongs to the GAB family.
Contains 1 PH domain.

SWISS:
Q9UQC2

Gene ID:
9846

Database links:

Entrez Gene: 9846 Human

Entrez Gene: 14389 Mouse

Entrez Gene: 84477 Rat

Omim: 606203 Human

SwissProt: Q9UQC2 Human

SwissProt: Q9Z1S8 Mouse

SwissProt: Q9EQH1 Rat

Unigene: 429434 Human

Unigene: 42033 Mouse

Unigene: 211990 Rat



產品圖片
Paraformaldehyde-fixed, paraffin embedded (Mouse brain); Antigen retrieval by microwave in sodium citrate buffer (pH6.0) ; Block endogenous peroxidase by 3% hydrogen peroxide for 30 minutes; Blocking buffer (3% BSA) at RT for 30min; Antibody incubation with (GAB2) Polyclonal Antibody, Unconjugated (bs-2885R) at 1:400 overnight at 4℃, followed by conjugation to the secondary antibody (labeled with HRP)and DAB staining.
Paraformaldehyde-fixed, paraffin embedded (Rat brain); Antigen retrieval by microwave in sodium citrate buffer (pH6.0) ; Block endogenous peroxidase by 3% hydrogen peroxide for 30 minutes; Blocking buffer (3% BSA) at RT for 30min; Antibody incubation with (GAB2) Polyclonal Antibody, Unconjugated (bs-2885R) at 1:400 overnight at 4℃, followed by conjugation to the secondary antibody (labeled with HRP)and DAB staining.
Blank control(blue): U-87MG(fixed with 2% paraformaldehyde (10 min) , then permeabilized with 90% ice-cold methanol for 30 min on ice). Primary Antibody:Rabbit Anti-DAB2 antibody(bs-2885R), Dilution: 1μg in 100 μL 1X PBS containing 0.5% BSA; Isotype Control Antibody: Rabbit IgG(orange) ,used under the same conditions ); Secondary Antibody: Goat anti-rabbit IgG-PE(white blue), Dilution: 1:200 in 1 X PBS containing 0.5% BSA.
版權所有 2004-2026 m.jywcc.com 北京博奧森生物技術有限公司
通過國際質量管理體系ISO 9001:2015 GB/T 19001-2016    證書編號: 00124Q34771R2M/1100
通過國際醫療器械-質量管理體系ISO 13485:2016 GB/T 42061-2022    證書編號: CQC24QY10047R0M/1100
京ICP備05066980號-1         京公網安備110107000727號
主站蜘蛛池模板: 精品无码aⅤ无码免费专区 93在线视频精品免费观看 | 高清无码专区av | 商场女厕偷拍一区二区三区视频 | 国产精品臀控福利在线观看 | 国产精品成人永久在线四虎 | aa一级片 | 日本黄色站 | 中文字幕人妻熟女人妻 | 性欧美人与zozoxxxx视频 | 亚洲成av人片在线观看 | 黄色免费在线看 | 丰满少妇aaaaa一级毛片 | 亚洲精品中文字幕av | 亚洲AV无码一区东京热蜜芽 | 亚洲国产精品大学美女久久久爽 | 老司机99久久99精品免费播放 | 99久久精品无码一区二区毛片 | 久久99久久精品视频 | 中文字幕第九页 | 成年肉动漫在线观看无码中文 | 玖玖在线精品免费视 | 97热视频在线 | 狠狠干夜夜干 | 国产女女做受ⅹxx高潮 | 亚洲AV综合色区无码另类小说 | v11av在线视频成人 | 少妇多水XXXX色情免费 | 国产日韩三级 | 九九视频国产免 | 好吊妞视频这里有精品 | 久在线观看视频 | 粗大的内捧猛烈进出少妇 | 亚洲一区视频在线 | 国产一卡2卡3卡4卡网站免费 | 91天堂素人| 亚洲精品你懂的 | 久久亚洲精品中文字幕无码 | 91视频污黄| 欧美三圾片在线观看 | 国产1区2区 | 亚洲日日摸夜夜夜夜夜爽小说 |