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CETP Rabbit pAb (bs-3694R)  
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產品編號 bs-3694R
英文名稱 CETP Rabbit pAb
中文名稱 膽固醇酯轉移蛋白抗體
別    名 BPIFF; CETP; CETP_HUMAN; Cholesteryl ester transfer; Cholesteryl ester transfer protein; Cholesteryl ester transfer protein plasma; Cholesteryl ester transfer protein precursor; HDLCQ10; Lipid transfer protein I.  
研究領域 腫瘤  心血管  細胞生物  免疫學  信號轉導  脂蛋白  新陳代謝  
抗體來源 Rabbit
克隆類型 Polyclonal
克 隆 號
交叉反應 Mouse (predicted: Human)
產品應用 WB=1:500-2000
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
理論分子量 53 kDa
檢測分子量
細胞定位 細胞外基質 分泌型蛋白 
性    狀 Liquid
濃    度 1mg/ml
免 疫 原 KLH conjugated synthetic peptide derived from human CETP: 355-450/493 
亞    型 IgG
純化方法 affinity purified by Protein A
緩 沖 液 0.01M TBS (pH7.4) with 1% BSA, 0.02% Proclin300 and 50% Glycerol.
保存條件 Shipped at 4℃. Store at -20℃ for one year. Avoid repeated freeze/thaw cycles.
注意事項 This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
PubMed PubMed
產品介紹 High density lipoproteins (HDLs) have been proposed to function jointly with lecithin:cholesterol acyltransferase and CETP to facilitate cholesterol transport from tissues to the liver. This mechanism, referred to as reverse cholesterol transport, is physiologically important because it maintains systemic cholesterol levels. CETP is responsible for neutral lipid transfer activity in plasma in numerous species. Since CETP is able to accelerate specifically the exchange of lipid components between pro- and anti-atherogenic lipoprotein fractions, it may be a key determinant of the global atherogenicity of the plasma lipoprotein profile and arises as a possible target in atherosclerosis prevention. CETP has an important role in reverse cholesterol transport and shaping and affecting the composition of plasma lipoproteins. In general elevated levels of CETP have been associated with increased risk of coronary heart disease.

Function:
Involved in the transfer of insoluble cholesteryl esters in the reverse transport of cholesterol.

Subcellular Location:
Secreted, extracellular space.

Tissue Specificity:
Expressed by the liver and secreted in plasma.

DISEASE:
Defects in CETP are the cause of hyperalphalipoproteinemia type 1 (HALP1) [MIM:143470]. Affected individuals show high levels of alpha-lipoprotein (high density lipoprotein/HDL).

Similarity:
Belongs to the BPI/LBP/Plunc superfamily. BPI/LBP family.

SWISS:
P11597

Gene ID:
1071

Database links:

Entrez Gene: 1071 Human

Omim: 118470 Human

SwissProt: P11597 Human

SwissProt: P22687 Rabbit

Unigene: 89538 Human



CETP系一疏水糖蛋白,膽固醇酯轉運蛋白--介導HDL中的膽固醇與VLDL中的甘油三酯等交換,促進HDL中的膽固醇凈轉運,可促進膽固醇酯在細胞與血漿脂蛋白間的轉運,參與膽固醇的逆轉運過程。
產品圖片
Sample: Cerebellum (Mouse) Lysate at 40 ug Primary: Anti- CETP (bs-3694R) at 1/1000 dilution Secondary: IRDye800CW Goat Anti-Rabbit IgG at 1/20000 dilution Predicted band size: 53 kD Observed band size: 53 kD
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