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GM-CSF Rabbit pAb (bs-3790R)  
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50ul/1180.00元
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產(chǎn)品編號(hào) bs-3790R
英文名稱 GM-CSF Rabbit pAb
中文名稱 粒細(xì)胞-巨噬細(xì)胞克隆刺激因子抗體
別    名 Granulocyte-Macrophage Colony Stimulating Factor; Burst Promoting Activity; CMCSF; Colony Stimulating Factor 2; Colony stimulating factor; CSF 2; CSF alpha; CSF; CSF2; Eosinophil Colony Stimulating Factor; GMCSF; Granulocyte Macrophage Colony Stimulating Factor; MGC131935; MGC138897; Molgramostin; Pluripoietin alpha; Sargramostim; granulocyte-macrophage colony-stimulating factor precursor; CSF2_HUMAN.  
Specific References  (6)     |     bs-3790R has been referenced in 6 publications.
[IF=19.572] Hilgendorf et al. Innate response activator B cells aggravate atherosclerosis by stimulating T helper-1 adaptive immunity. (2014) Circulatio. 129:1677-87  IHC-P ;  Human.  
[IF=11] Anzai, Atsushi, et al. "The infarcted myocardium solicits GM-CSF for the detrimental oversupply of inflammatory leukocytes." Journal of Experimental Medicine (2017): jem-20170689.  IHC-P ;  Mouse.  
[IF=10.79] Anzai et al. The infarcted myocardium solicits GM-CSF for the detrimental oversupply of inflammatory leukocytes. (2017) J.Exp.Med. 214:3293-3310  IHC-P ;  Mouse.  
[IF=6.129] Papp KA et al. GM-CSF as a therapeutic target in psoriasis: randomised, controlled investigation using namilumab - a specific, human anti-GM-CSF monoclonal antibody.(2018) Br. J. Dermatol. Sep 12  Human.  
[IF=5.875] Yuan SJ. et al. Conjugation with nanodiamonds via hydrazone bond fundamentally alters intracellular distribution and activity of doxorubicin.. Int J Pharmaceut. 2021 Jul;606:120872-120872  IHC ;  Mouse.  
[IF=0.3] Li, Zhen, et al. "Methods for transferring gene into silkworm and expression of hGM-CSF in silk glands of transgenic silkworm." Journal of Chemical and Pharmaceutical Research 6.5 (2014): 118-129.  WB ;  
研究領(lǐng)域 腫瘤  免疫學(xué)  信號(hào)轉(zhuǎn)導(dǎo)  趨化因子  細(xì)胞表面分子  
抗體來源 Rabbit
克隆類型 Polyclonal
克 隆 號(hào)
交叉反應(yīng) Pig (predicted: Human,Mouse,Rat,Rabbit,Cow,Chicken,Dog,Recombinant protein)
產(chǎn)品應(yīng)用 WB=1:500-2000
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
理論分子量 14 kDa
檢測分子量
細(xì)胞定位 分泌型蛋白 
性    狀 Liquid
濃    度 1mg/ml
免 疫 原 KLH conjugated synthetic peptide derived from human GM-CSF: 65-144/144 
亞    型 IgG
純化方法 affinity purified by Protein A
緩 沖 液 0.01M TBS (pH7.4) with 1% BSA, 0.02% Proclin300 and 50% Glycerol.
保存條件 Shipped at 4℃. Store at -20℃ for one year. Avoid repeated freeze/thaw cycles.
注意事項(xiàng) This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
PubMed PubMed
產(chǎn)品介紹 The protein encoded by this gene is a cytokine that controls the production, differentiation, and function of granulocytes and macrophages. The active form of the protein is found extracellularly as a homodimer. This gene has been localized to a cluster of related genes at chromosome region 5q31, which is known to be associated with interstitial deletions in the 5q- syndrome and acute myelogenous leukemia. Other genes in the cluster include those encoding interleukins 4, 5, and 13. [provided by RefSeq, Jul 2008].

Function:
Cytokine that stimulates the growth and differentiation of hematopoietic precursor cells from various lineages, including granulocytes, macrophages, eosinophils and erythrocytes.

Subunit:
Monomer. The signaling GM-CSF receptor complex is a dodecamer of two head-to-head hexamers of two alpha, two beta, and two ligand subunits.

Subcellular Location:
Secreted.

Similarity:
Belongs to the GM-CSF family.

Gene ID:
1437

Database links:

Entrez Gene: 1437 Human

Omim: 138960 Human

SwissProt: P04141 Human



GM-CSF是血管內(nèi)皮細(xì)胞、單核細(xì)胞和成纖維細(xì)胞合成的糖蛋白。能促進(jìn)中性粒細(xì)胞成熟;刺激成熟的粒細(xì)胞從骨髓釋出;增強(qiáng)中性粒細(xì)胞趨化及吞噬功能。
產(chǎn)品圖片
Sample: Lane 1: Recombined Trx/His-tag porcine?GM-CSF protein (Aa18-144) at 2 ug Lane 2: Recombined?His-tag?porcine?GM-CSF protein Primary: Anti-GM-CSF (bs-3790R) at 1/1000 dilution Secondary: IRDye800CW Goat Anti-Rabbit IgG at 1/20000 dilution Predicted band size: 33/15 kD Observed band size: 33/15 kD
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