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ATG4C Rabbit pAb (bs-4008R)  
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產品編號 bs-4008R
英文名稱 ATG4C Rabbit pAb
中文名稱 自噬相關蛋白4C抗體
別    名 APG4 autophagy 4 homolog C(S. cerevisiae); APG4 autophagy 4 homolog C; APG4 C; APG4-C; APG4C; ATG 4C; ATG4 autophagy related 4 homolog C(S. cerevisiae); Atg4c; ATG4C_HUMAN; AUT(S. cerevisiae) like 1, cysteine endopeptidase; AUT like 1, cysteine endopeptidase(S. cerevisiae); AUT like 1, cysteine endopeptidase; AUT like 3 cysteine endopeptidase; AUT-like 3 cysteine endopeptidase; AUTL1; AUTL3; Autophagin 3; Autophagin-3; Autophagy related cysteine endopeptidase 3; Autophagy related protein 4 homolog C; Autophagy-related cysteine endopeptidase 3; Autophagy-related protein 4 homolog C; Cysteine protease ATG4C; EC 3.4.22; FLJ14867; OTTHUMP00000010715.  
研究領域 腫瘤  心血管  細胞生物  免疫學  信號轉導  細胞凋亡  激酶和磷酸酶  線粒體  泛素  
抗體來源 Rabbit
克隆類型 Polyclonal
克 隆 號
交叉反應 Human,Mouse,Rat (predicted: Rabbit,Pig,Cow,Dog,Horse)
產品應用 WB=1:500-2000
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
理論分子量 52 kDa
檢測分子量
細胞定位 細胞核 細胞漿 線粒體
性    狀 Liquid
濃    度 1mg/ml
免 疫 原 KLH conjugated synthetic peptide derived from human ATG4C: 201-300/458 
亞    型 IgG
純化方法 affinity purified by Protein A
緩 沖 液 0.01M TBS (pH7.4) with 1% BSA, 0.02% Proclin300 and 50% Glycerol.
保存條件 Shipped at 4℃. Store at -20℃ for one year. Avoid repeated freeze/thaw cycles.
注意事項 This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
PubMed PubMed
產品介紹 Cysteine protease required for autophagy, which cleaves the C-terminal part of either MAP1LC3, GABARAPL2 or GABARAP, allowing the liberation of form I. A subpopulation of form I is subsequently converted to a smaller form (form II). Form II, with a revealed C-terminal glycine, is considered to be the phosphatidylethanolamine (PE)-conjugated form, and has the capacity for the binding to autophagosomes.

Function:
Cysteine protease required for autophagy, which cleaves the C-terminal part of either MAP1LC3, GABARAPL2 or GABARAP, allowing the liberation of form I. A subpopulation of form I is subsequently converted to a smaller form (form II). Form II, with a revealed C-terminal glycine, is considered to be the phosphatidylethanolamine (PE)-conjugated form, and has the capacity for the binding to autophagosomes.

Subcellular Location:
Cytoplasm (Probable).

Tissue Specificity:
Highly expressed in skeletal muscle, heart, liver and testis.

Similarity:
Belongs to the peptidase C54 family.

SWISS:
Q96DT6

Gene ID:
84938

Database links:

Entrez Gene: 84938 Human

Entrez Gene: 242557 Mouse

Entrez Gene: 313391 Rat

Omim: 611339 Human

SwissProt: Q96DT6 Human

SwissProt: Q811C2 Mouse

Unigene: 7353 Human

Unigene: 241663 Mouse

Unigene: 23378 Rat



產品圖片
Sample: Lane 1: Mouse Muscle tissue lysates Lane 2: Mouse Heart tissue lysates Lane 3: Rat Muscle tissue lysates Primary: Anti-ATG4C (bs-4008R) at 1/1000 dilution Secondary: IRDye800CW Goat Anti-Rabbit IgG at 1/20000 dilution Predicted band size: 52 kDa Observed band size: 52 kDa
Sample: Liver (Mouse) Lysate at 40 ug Primary: Anti-ATG4C (bs-4008R) at 1/1000 dilution Secondary: IRDye800CW Goat Anti-Rabbit IgG at 1/20000 dilution Predicted band size: 52 kD Observed band size: 55 kD
Sample: A673(Human) Cell Lysate at 30 ug Primary: Anti-ATG4C (bs-4008R) at 1/1000 dilution Secondary: IRDye800CW Goat Anti-Rabbit IgG at 1/20000 dilution Predicted band size: 52 kD Observed band size: 55 kD
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