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Alpha 2 antiplasmin Rabbit pAb (bs-6188R)  
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50ul/1180.00元
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產品編號 bs-6188R
英文名稱 Alpha 2 antiplasmin Rabbit pAb
中文名稱 α2纖溶酶色素上皮衍生因子抗體
別    名 A2AP; A2AP_HUMAN; AAP; alpha 2 antiplasmin; alpha 2 antiplasmin pigment epithelium derived factor; alpha 2 AP; ALPHA 2 PI; alpha 2 plasmin inhibitor; alpha 2 plasmin inhibitor deficiency; alpha-2-antiplasmin; alpha-2-AP; alpha-2-PI; alpha-2-plasmin inhibitor; Antiplasmin deficiency; API; Plasmin inhibitor deficiency; PLI; Serine(or cysteine) peptidase inhibitor, clade F, member 2; Serine(Or cysteine) peptidase inhibitor, clade F, member 2, isoform CRA_c; Serine(or cysteine) proteinase inhibitor, clade F(alpha 2 antiplasmin pigment epithelium derived factor) member 2; Serine(Or cysteine) proteinase inhibitor, clade F, member 2; Serine or cysteine peptidase inhibitor clade F member 2; Serpin F2; Serpin peptidase inhibitor clade F; Serpin peptidase inhibitor, clade F(alpha 2 antiplasmin pigment epithelium derived factor) member 2; SERPINF2.  
Specific References  (1)     |     bs-6188R has been referenced in 1 publications.
[IF=3.989] Schmal et al. Hematopoietic Stem and Progenitor Cell Expansion in Contact with Mesenchymal Stromal Cells in a Hanging Drop Model Uncovers Disadvantages of 3D Culture. (2016) Stem.Cells.Int. 2016:4148093  IF ;  Human,?Mouse,?Rat,?Dog,?Horse,?Rabbit.  
研究領域 心血管  細胞生物  免疫學  泛素  
抗體來源 Rabbit
克隆類型 Polyclonal
克 隆 號
交叉反應 Human,Mouse,Rat (predicted: Rabbit,Dog,Horse)
產品應用 WB=1:500-2000,IHC-P=1:100-500,IHC-F=1:100-500,IF=1:100-500
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
理論分子量 50 kDa
檢測分子量
細胞定位 分泌型蛋白 
性    狀 Liquid
濃    度 1mg/ml
免 疫 原 KLH conjugated synthetic peptide derived from human SERPINF2: 161-260/491 
亞    型 IgG
純化方法 affinity purified by Protein A
緩 沖 液 0.01M TBS (pH7.4) with 1% BSA, 0.02% Proclin300 and 50% Glycerol.
保存條件 Shipped at 4℃. Store at -20℃ for one year. Avoid repeated freeze/thaw cycles.
注意事項 This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
PubMed PubMed
產品介紹 Alpha 2 Antiplasmin is a member of the serpin family of serine protease inhibitors. The protein is a major inhibitor of plasmin, which degrades fibrin and various other proteins. Consequently, the proper function of this gene has a major role in regulating the blood clotting pathway. Mutations in this gene result in alpha-2-plasmin inhibitor deficiency, which is characterized by severe hemorrhagic diathesis. Multiple transcript variants encoding different isoforms have been found for this gene.

Function:
Serine protease inhibitor. The major targets of this inhibitor are plasmin and trypsin, but it also inactivates matriptase-3/TMPRSS7 and chymotrypsin.

Subunit:
Forms protease inhibiting heterodimer with TMPRSS7.

Subcellular Location:
Secreted.

Tissue Specificity:
Expressed by the liver and secreted in plasma.

DISEASE:
Alpha-2-plasmin inhibitor deficiency (APLID) [MIM:262850]: An autosomal recessive disorder resulting in severe hemorrhagic diathesis. Note=The disease is caused by mutations affecting the gene represented in this entry.

Similarity:
Belongs to the serpin family.

SWISS:
P08697

Gene ID:
5345

Database links:

Entrez Gene: 5345 Human

Omim: 613168 Human

SwissProt: P08697 Human

Unigene: 159509 Human



產品圖片
Sample: Liver (Mouse) Lysate at 40 ug Primary: Anti- Alpha 2 antiplasmin (bs-6188R) at 1/1000 dilution Secondary: IRDye800CW Goat Anti-Rabbit IgG at 1/20000 dilution Predicted band size: 50 kD Observed band size: 52 kD
Paraformaldehyde-fixed, paraffin embedded (human liver); Antigen retrieval by boiling in sodium citrate buffer (pH6.0) for 15min; Block endogenous peroxidase by 3% hydrogen peroxide for 20 minutes; Blocking buffer (normal goat serum) at 37°C for 30min; Antibody incubation with (Alpha 2 antiplasmin) Polyclonal Antibody, Unconjugated (bs-6188R) at 1:200 overnight at 4°C, followed by operating according to SP Kit(Rabbit) (sp-0023) instructionsand DAB staining.
Paraformaldehyde-fixed, paraffin embedded (rat liver); Antigen retrieval by boiling in sodium citrate buffer (pH6.0) for 15min; Block endogenous peroxidase by 3% hydrogen peroxide for 20 minutes; Blocking buffer (normal goat serum) at 37°C for 30min; Antibody incubation with (Alpha 2 antiplasmin) Polyclonal Antibody, Unconjugated (bs-6188R) at 1:200 overnight at 4°C, followed by operating according to SP Kit(Rabbit) (sp-0023) instructionsand DAB staining.
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