麻豆av资源_日本三级一区_www.狠狠艹_国产精妇在线观看第一区_成人性生交大片免费看中国A片_日本一本久久

掃碼關注公眾號           掃碼咨詢技術支持           掃碼咨詢技術服務
  
客服熱線:400-901-9800  客服QQ:4009019800  技術答疑  技術支持  質量反饋  關于我們  聯系我們
靠比视频免费观看,色情狠久久AV五月综合五月,久爱www人成视频在线观看
首頁 > 產品中心 > 一抗 > 產品信息
ApoER2 Rabbit pAb (bs-6651R)  
訂購熱線:400-901-9800
訂購郵箱:sales@bioss.com.cn
訂購QQ:  400-901-9800
技術支持:techsupport@bioss.com.cn
50ul/1180.00元
100ul/1980.00元
200ul/2800.00元
大包裝/詢價

產品編號 bs-6651R
英文名稱 ApoER2 Rabbit pAb
中文名稱 載脂蛋白E2受體抗體
別    名 APOER2; Apolipoprotein E receptor 2; low density lipoprotein receptor-related protein 8; Low-density lipoprotein receptor-related protein 8; LRP-8; LRP8; LRP8_HUMAN.  
研究領域 心血管  神經生物學  信號轉導  細胞膜受體  細胞自噬  
抗體來源 Rabbit
克隆類型 Polyclonal
克 隆 號
交叉反應 Human,Mouse,Rat (predicted: Rabbit,Pig,Cow,Chicken,Dog,Horse)
產品應用 WB=1:500-2000,IHC-P=1:100-500,IHC-F=1:100-500,IF=1:100-500
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
理論分子量 102 kDa
檢測分子量
細胞定位 細胞膜 分泌型蛋白 
性    狀 Liquid
濃    度 1mg/ml
免 疫 原 KLH conjugated synthetic peptide derived from human ApoER2: 851-963/963 
亞    型 IgG
純化方法 affinity purified by Protein A
緩 沖 液 0.01M TBS (pH7.4) with 1% BSA, 0.02% Proclin300 and 50% Glycerol.
保存條件 Shipped at 4℃. Store at -20℃ for one year. Avoid repeated freeze/thaw cycles.
注意事項 This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
PubMed PubMed
產品介紹 Cell surface receptor for Reelin (RELN) and apolipoprotein E (apoE)-containing ligands. LRP8 participates in transmitting the extracellular Reelin signal to intracellular signaling processes, by binding to DAB1 on its cytoplasmic tail. Reelin acts via both the VLDL receptor (VLDLR) and LRP8 to regulate DAB1 tyrosine phosphorylation and microtubule function in neurons. LRP8 has higher affinity for Reelin than VLDLR. LRP8 is thus a key component of the Reelin pathway which governs neuronal layering of the forebrain during embryonic brain development. Binds the endoplasmic reticulum resident receptor-associated protein (RAP). Binds dimers of beta 2-glycoprotein I and may be involved in the suppression of platelet aggregation in the vasculature. Highly expressed in the initial segment of the epididymis, where it affects the functional expression of clusterin and phospholipid hydroperoxide glutathione peroxidase (PHGPx), two proteins required for sperm maturation. May also function as an endocytic receptor.

Function:
Cell surface receptor for Reelin (RELN) and apolipoprotein E (apoE)-containing ligands. LRP8 participates in transmitting the extracellular Reelin signal to intracellular signaling processes, by binding to DAB1 on its cytoplasmic tail. Reelin acts via both the VLDL receptor (VLDLR) and LRP8 to regulate DAB1 tyrosine phosphorylation and microtubule function in neurons. LRP8 has higher affinity for Reelin than VLDLR. LRP8 is thus a key component of the Reelin pathway which governs neuronal layering of the forebrain during embryonic brain development. Binds the endoplasmic reticulum resident receptor-associated protein (RAP). Binds dimers of beta 2-glycoprotein I and may be involved in the suppression of platelet aggregation in the vasculature. Highly expressed in the initial segment of the epididymis, where it affects the functional expression of clusterin and phospholipid hydroperoxide glutathione peroxidase (PHGPx), two proteins required for sperm maturation. May also function as an endocytic receptor.

Subunit:
Reelin associates with two or more receptor molecules. Interacts with DAB1 and JNK-interacting proteins. Interacts with SNX17 (By similarity).

Subcellular Location:
Cell membrane. Secreted. Isoforms that contain the exon coding for a furin-type cleavage site are proteolytically processed, leading to a secreted receptor fragment.

Tissue Specificity:
Expressed mainly in brain and placenta. Also expressed in platelets and megakaryocytic cells. Not expressed in the liver.

Post-translational modifications:
O-glycosylated. Some alternatively spliced isoforms lack the O-linked sugar domain. Undergoes sequential, furin and gamma-secretase dependent, proteolytic processing, resulting in the extracellular release of the entire ligand-binding domain as a soluble polypeptide and in the intracellular domain (ICD) release into the cytoplasm. The gamma-secretase-dependent proteolytical processing occurs after the bulk of the extracellular domain has been shed, in a furin-dependent manner, in alternatively spliced isoforms carrying the furin cleavage site. Hypoglycosylation (mainly hypo-O-glycosylation) leads to increased extracellular cleavage, which in turn results in accelerating release of the intracellular domain (ICD) by the gamma-secretase. The resulting receptor fragment is able to inhibit Reelin signaling and in particular the Reelin-induced DAB1 phosphorylation.
Tyrosine phosphorylated upon apoE binding.
Ubiquitinated by MYLIP leading to degradation.

DISEASE:
Defects in LRP8 are a cause of myocardial infarction type 1 (MCI1) [MIM:608446]. A condition defined by the irreversible necrosis of heart muscle secondary to prolonged ischemia.

Similarity:
Belongs to the LDLR family.
Contains 2 EGF-like domains.
Contains 7 LDL-receptor class A domains.
Contains 5 LDL-receptor class B repeats.

SWISS:
Q14114

Gene ID:
7804

Database links:

Entrez Gene: 7804 Human

Entrez Gene: 16975 Mouse

Entrez Gene: 362558 Rat

Omim: 602600 Human

SwissProt: Q14114 Human

SwissProt: Q924X6 Mouse

Unigene: 726256 Human

Unigene: 442134 Mouse

Unigene: 198283 Rat



產品圖片
Sample: Lane 1: Lung (Mouse) Lysate at 40 ug Lane 2: Lung (Rat) Lysate at 40 ug Lane 3: U87MG (Human) Lysate at 40 ug Lane 4: Hela (Human) Lysate at 40 ug Primary: Anti-ApoER2 (bs-6651R) at 1/1000 dilution Secondary: IRDye800CW Goat Anti-Rabbit IgG at 1/20000 dilution Predicted band size: 170/130 kD Observed band size: 130/125 kD
Tissue/cell: rat brain tissue; 4% Paraformaldehyde-fixed and paraffin-embedded; Antigen retrieval: citrate buffer ( 0.01M, pH 6.0 ), Boiling bathing for 15min; Block endogenous peroxidase by 3% Hydrogen peroxide for 30min; Blocking buffer (normal goat serum,C-0005) at 37℃ for 20 min; Incubation: Anti-ApoER2 Polyclonal Antibody, Unconjugated(bs-6651R) 1:200, overnight at 4°C, followed by conjugation to the secondary antibody(SP-0023) and DAB(C-0010) staining
版權所有 2004-2026 m.jywcc.com 北京博奧森生物技術有限公司
通過國際質量管理體系ISO 9001:2015 GB/T 19001-2016    證書編號: 00124Q34771R2M/1100
通過國際醫療器械-質量管理體系ISO 13485:2016 GB/T 42061-2022    證書編號: CQC24QY10047R0M/1100
京ICP備05066980號-1         京公網安備110107000727號
主站蜘蛛池模板: 激情伊人网| 99精品欧美一区二区三区黑人哦 | 国产精品一区二区麻豆 | 中文无码一区二区不卡αv 青青成线在人线免费啪 | 狠狠色综合网久久久久久 | 亚洲人成网站77777·C0M | 日韩人妻潮喷中文在线视频 | 国产66av| 国产精品成人免费综合网 | 我想看国产一级片 | CHINESEXXXXHD麻豆| 久久久久久成人网 | 一及黄色片| 奶茶视频有容乃大海纳百川有容乃大绿巨人 | 久久国产亚洲欧美久久 | 水菜丽成人av在线亚洲 | 粗长巨龙挤进新婚少妇未删版 | 国产一级一片射内视频 | 视频一区国产精品 | 惊弦45集在线看 | 天天干天天射天天爽 | 久久精品国产视频 | 精品va天堂亚洲国产 | 波多野AV一区二区无码 | 日本少妇人妻XXXXX18免费 | 午夜免费福利视频 | 国产成人午夜性a一级毛片 69亚洲精品久久久蜜桃小说 | 国模大胆无码私拍啪啪AV | 国产10000部拍拍拍免费视频 | 老熟妇乱子交视频一区 | 久草视频免费在线播放 | 免费无码午夜福利片69 | 小草成人免费视频 | 国产午夜视频 | 欧美a一级| 成年美女黄网站色大片免费软件看 | 在线成人精品国产区免费 | 欧美日韩不卡一区二区三区 | 亚洲国产一区视频 | 欧产日产国产精品v原神 | 国产欧美亚洲精品第一区软件 |