麻豆av资源_日本三级一区_www.狠狠艹_国产精妇在线观看第一区_成人性生交大片免费看中国A片_日本一本久久

掃碼關注公眾號           掃碼咨詢技術支持           掃碼咨詢技術服務
  
客服熱線:400-901-9800  客服QQ:4009019800  技術答疑  技術支持  質量反饋  關于我們  聯系我們
国产高潮A片一区二区,国产剧情乱偷,久草日B视频一二三区
首頁 > 產品中心 > 一抗 > 產品信息
PVRL1 Rabbit pAb (bs-11126R)  
訂購熱線:400-901-9800
訂購郵箱:sales@bioss.com.cn
訂購QQ:  400-901-9800
技術支持:techsupport@bioss.com.cn
50ul/1180.00元
100ul/1980.00元
200ul/2800.00元
大包裝/詢價

產品編號 bs-11126R
英文名稱 PVRL1 Rabbit pAb
中文名稱 脊髓灰質炎受體相關蛋白1抗體
別    名 CD111; CD111 antigen; CLPED1; ectodermal dysplasia 4(Margarita Island type); ED4; Herpes virus entry mediator C; Herpesvirus entry mediator C; Herpesvirus Ig like receptor; Herpesvirus Ig-like receptor; HIgR; HveC; Nectin 1; Nectin-1; Nectin1; OFC7; OROFACIAL CLEFT 7; Poliovirus receptor related protein 1; poliovirus receptor-like 1; Poliovirus receptor-related protein 1; PRR; PRR1; PVRL 1; PVRL1; PVRL1_HUMAN; PVRR; PVRR1; SK-12.  
Specific References  (1)     |     bs-11126R has been referenced in 1 publications.
[IF=0] Iskandar RPD et al. The densitometric analysis of protein pattern in cleft lip and palate patients. J Int Soc Prev Community Dent. 2019 May-Jun;9(3):240-244.  Dot-Blot ;  Human.  
研究領域 神經生物學  細胞膜蛋白  
抗體來源 Rabbit
克隆類型 Polyclonal
克 隆 號
交叉反應 Human,Mouse,Rat (predicted: Rabbit,Cow,Dog)
產品應用 WB=1:500-2000,IHC-P=1:100-500,IHC-F=1:100-500,IF=1:100-500
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
理論分子量 54 kDa
檢測分子量
細胞定位 細胞膜 分泌型蛋白 
性    狀 Liquid
濃    度 1mg/ml
免 疫 原 KLH conjugated synthetic peptide derived from human PVRL1/CD111/Nectin1: 31-130/517 <Extracellular>
亞    型 IgG
純化方法 affinity purified by Protein A
緩 沖 液 0.01M TBS (pH7.4) with 1% BSA, 0.02% Proclin300 and 50% Glycerol.
保存條件 Shipped at 4℃. Store at -20℃ for one year. Avoid repeated freeze/thaw cycles.
注意事項 This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
PubMed PubMed
產品介紹 Nectin is a Ca2+-independent homophilic cell adhesion molecule that belongs to the immunoglobulin superfamily. Human Nectin is identical to the poliovirus receptor-related protein (PRR) and is identified to be the alphaherpesvirus entry mediator. Nectin constitutes a family consisting of at least nectin 1, 2 and 3. Nectin 2 and 3 are ubiquitously expressed, whereas nectin 1 is abundantly expressed in the brain. Nectin 1 exists as nectin 1? and 1∫/HIgR, produced by alternative splicing. The cytoplasmic regions of Nectin 1?, but not Nectin 1∫/HIgR, have a C-terminal conserved motif (E/A-X-Y-V). This motif interacts with the PDZ domain of the F-Actin-binding protein, afadin, through which it is linked to the Actin cytoskeleton. Nectin 1, also designated HveC/ PRR1, allows the entry of herpes simplex virus type 1 (HSV-1) and HSV-2 into mammalian cells. The interaction of virus envelope glycoprotein D (gD) with nectin 1 is an essential step in the process leading to membrane fusion; the gD binding site is located at the first Ig-like domain of Nectin 1. Both the transinteraction of nectin and the interaction of nectin with afadin are necessary for their co-localization with E-cadherin and catenins at adherens junctions.

Function:
Promotes cell-cell contacts by forming homophilic or heterophilic trans-dimers. Heterophilic interactions have been detected between PVRL1/nectin-1 and PVRL3/nectin-3 and between PVRL1/nectin-1 and PVRL4/nectin-4.

Subunit:
Can form trans-heterodimers with PVRL3/nectin-3 and with PVRL4/nectin-4. Interacts (via C-terminus) with afadin (via PDZ domain); this interaction recruits PVRL1 to cadherin-based adherens junctions. Interacts with integrin alphaV/beta3. Interacts with herpes simplex virus 1 (HHV-1), herpes simplex virus 2 (HHV-2), and pseudorabies virus (PRV) envelope glycoprotein D; functions as an entry receptor for these viruses.

Subcellular Location:
Isoform Alpha: Cell membrane; Single-pass type I membrane protein. Isoform Delta: Cell membrane; Single-pass type I membrane protein. Isoform Gamma: Secreted.

DISEASE:
Defects in PVRL1 are the cause of ectodermal dysplasia Margarita Island type (EDMI) [MIM:225060]; also known as Zlotogora-Ogur syndrome, cleft lip/palate-ectodermal dysplasia syndrome (CLPED1) or ectodermal dysplasia 4. Ectodermal dysplasia defines a heterogeneous group of disorders due to abnormal development of two or more ectodermal structures. EDMI is an autosomal recessive syndrome characterized by the association of cleft lip/palate, ectodermal dysplasia (sparse short and dry scalp hair, sparse eyebrows and eyelashes), and partial syndactyly of the fingers and/or toes. Two thirds of the patients do not manifest oral cleft but present with abnormal teeth and nails.

Similarity:
Belongs to the nectin family.
Contains 2 Ig-like C2-type (immunoglobulin-like) domains.
Contains 1 Ig-like V-type (immunoglobulin-like) domain.

SWISS:
Q15223

Gene ID:
5818

Database links:

Entrez Gene: 5818 Human

Entrez Gene: 58235 Mouse

Entrez Gene: 397247 Pig

Entrez Gene: 192183 Rat

Omim: 600644 Human

SwissProt: Q15223 Human

SwissProt: Q9JKF6 Mouse

SwissProt: Q9GL76 Pig

Unigene: 334846 Human

Unigene: 335096 Mouse



產品圖片
Sample: Lane 1: Human U87MG cell lysates Lane 2: Human SH-SY5Y cell lysates Primary: Anti-PVRL1 (bs-11126R) at 1/1000 dilution Secondary: IRDye800CW Goat Anti-Rabbit IgG at 1/20000 dilution Predicted band size: 54 kDa Observed band size: 54 kDa
Sample: Lane 1: Mouse Urinary bladder tissue lysates Lane 2: Rat Urinary bladder tissue lysates Primary: Anti-PVRL1 (bs-11126R) at 1/1000 dilution Secondary: IRDye800CW Goat Anti-Rabbit IgG at 1/20000 dilution Predicted band size: 54 kDa Observed band size: 57 kDa
Paraformaldehyde-fixed, paraffin embedded (Rat brain); Antigen retrieval by boiling in sodium citrate buffer (pH6.0) for 15min; Block endogenous peroxidase by 3% hydrogen peroxide for 20 minutes; Blocking buffer (normal goat serum) at 37°C for 30min; Antibody incubation with (PVRL1) Polyclonal Antibody, Unconjugated (bs-11126R) at 1:400 overnight at 4°C, followed by operating according to SP Kit(Rabbit) (sp-0023) instructionsand DAB staining.
Paraformaldehyde-fixed, paraffin embedded (Rat brain); Antigen retrieval by boiling in sodium citrate buffer (pH6.0) for 15min; Block endogenous peroxidase by 3% hydrogen peroxide for 20 minutes; Blocking buffer (normal goat serum) at 37°C for 30min; Antibody incubation with (PVRL1) Polyclonal Antibody, Unconjugated (bs-11126R) at 1:400 overnight at 4°C, followed by operating according to SP Kit(Rabbit) (sp-0023) instructionsand DAB staining.
版權所有 2004-2026 m.jywcc.com 北京博奧森生物技術有限公司
通過國際質量管理體系ISO 9001:2015 GB/T 19001-2016    證書編號: 00124Q34771R2M/1100
通過國際醫療器械-質量管理體系ISO 13485:2016 GB/T 42061-2022    證書編號: CQC24QY10047R0M/1100
京ICP備05066980號-1         京公網安備110107000727號
主站蜘蛛池模板: 韩国男男腐啪GV肉视频 | 激情亚洲AV无码日韩色 | www.69视频 | 国产福利片无码区在线观看 | 成人黄色小说网站 | 五月激情av | 美女内射毛片在线看免费人动物 | 日本精品www| 一起草视频在线播放 | 亚洲av日韩av无码黑人 | 天天做天天爱天天高潮 | 97黑人性色浪潮91久久 | 亚洲色婷婷久久精品AV蜜桃久久 | 高清偷自拍亚洲精品三区 | 精品视频一区二区三区四区 | a级免费片 | 91色版| 乱一色一毛一片 | 四虎影视在线观看2413 | 国产精品视频播放 | 97夜夜澡人人爽人人 | 啪啪免费网 | 亚洲草片 | 色诱久久久久综合网YWWW | 欧美日韩51精品 | 亚洲国产成人久久综合人 | 亚洲AV成人片无码WWW | 日韩av无码久久一区二区 | 乌克兰肥妇黑毛BBW 99热热精品 | 国产偷窥女洗浴在线观看亚洲 | 日韩免费看视频 | 飘香影院午夜理论片A片 | 美女高潮无套内谢视频免费 | 国产精品99无码一区二区 | xxxxx欧美丰满大屁股大屁股 | 中文字幕亚洲免费 | 免费网站看av| 亚洲AV蜜桃永久无码精品 | 男男无码sm调教gv资源 | 日韩亚洲欧美中文高清在线 | 久久久88 |