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Connexin 31.1 Rabbit pAb (bs-13734R)  
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產品編號 bs-13734R
英文名稱 Connexin 31.1 Rabbit pAb
中文名稱 間隙連接蛋白31.1/GJB5抗體
別    名 Connexin 31.1; Connexin-31.1; Connexin31.1; Cx31.1; CXB5_HUMAN; Gap junction beta 5 protein; Gap junction beta-5 protein; Gap junction protein beta 5 31.1kDa; Gap junction protein beta 5; GJB 5; GJB5.  
研究領域 腫瘤  細胞生物  信號轉導  細胞粘附分子  跨膜蛋白  
抗體來源 Rabbit
克隆類型 Polyclonal
克 隆 號
交叉反應 Mouse (predicted: Human,Rat,Rabbit,Sheep,Cow,Dog,Horse)
產品應用 WB=1:500-2000
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
理論分子量 31 kDa
檢測分子量
細胞定位 細胞膜 
性    狀 Liquid
濃    度 1mg/ml
免 疫 原 KLH conjugated synthetic peptide derived from human Connexin 31.1: 1-100/273 
亞    型
純化方法 affinity purified by Protein A
緩 沖 液 0.01M TBS (pH7.4) with 1% BSA, 0.02% Proclin300 and 50% Glycerol.
保存條件 Shipped at 4℃. Store at -20℃ for one year. Avoid repeated freeze/thaw cycles.
注意事項 This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
PubMed PubMed
產品介紹 The connexin family of proteins form hexameric complexes, called connexons, that facilitate movement of low molecular weight proteins between cells via gap junctions. Connexin proteins share a common topology of four transmembrane ?helical domains, two extracellular loops, a cytoplasmic loop and cytoplasmic N- and C-termini. Many of the key functional differences arise from specific amino acid substitutions in the most highly conserved domains; the transmembrane and extracellular regions. Connexin 31.1, Cx31.1 or Gap junction beta-5 protein, is a 271 amino acid protein that is predominantly expressed in skin with lower expression in testis. Expression of connexin 31.1 is required for normal placental development in mice. Down-regulation of the connexin 31.1 gene correlates with head and neck squamous cell carcinomas (HNSCC) and therefore it may be a potential therapeutic target.

Function:
One gap junction consists of a cluster of closely packed pairs of transmembrane channels, the connexons, through which materials of low MW diffuse from one cell to a neighboring cell.

Subcellular Location:
Cell membrane. Cell junction > gap junction.

Similarity:
Belongs to the connexin family. Beta-type (group I) subfamily.

SWISS:
O95377

Gene ID:
2709

Database links:

Entrez Gene: 2709 Human

Omim: 604493 Human

SwissProt: O95377 Human

Unigene: 198249 Human



產品圖片
Sample: Raw264.7(Mouse) Cell Lysate at 30 ug Primary: Anti- Connexin 31.1 (bs-13734R) at 1/1000 dilution Secondary: IRDye800CW Goat Anti-Rabbit IgG at 1/20000 dilution Predicted band size: 31 kD Observed band size: 31 kD
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