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CD244 Rabbit pAb (bs-13776R)  
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產品編號 bs-13776R
英文名稱 CD244 Rabbit pAb
中文名稱 CD244自然殺傷細胞受體2B4抗體
別    名 2b4 cDNA 2B4; CD244 natural killer cell receptor 2B4; Natural killer cell receptor 2B4; NK cell receptor 2B4; NKR2B4; CD244_HUMAN.  
研究領域 細胞生物  信號轉導  自然殺傷細胞  t-淋巴細胞  
抗體來源 Rabbit
克隆類型 Polyclonal
克 隆 號
交叉反應 Human (predicted: Mouse,Rat)
產品應用 WB=1:500-2000
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
理論分子量 39 kDa
檢測分子量
細胞定位 細胞膜 
性    狀 Liquid
濃    度 1mg/ml
免 疫 原 KLH conjugated synthetic peptide derived from human NKR2B4: 1-100/370 <Extracellular>
亞    型 IgG
純化方法 affinity purified by Protein A
緩 沖 液 0.01M TBS (pH7.4) with 1% BSA, 0.02% Proclin300 and 50% Glycerol.
保存條件 Shipped at 4℃. Store at -20℃ for one year. Avoid repeated freeze/thaw cycles.
注意事項 This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
PubMed PubMed
產品介紹 Natural killer (NK) cells are bone marrow-derived lymphocytes that can kill certain tumor cells and virally infected cells. There are multiple immunoglobulin superfamily (IgSF) receptor-ligand interactions that coordinate NK cell recognition of target cells and cytolytic function. The IgSF receptor NK 2B4 (CD244) is a ligand for CD48 that is expressed on the surface of all mouse and human NK cells and the subset of T cells that mediate NK-like killing. NK 2B4 is a cell surface glycoprotein of the immunoglobulin superfamily that is involved in the regulation of natural killer and T lymphocyte function. NK 2B4 binds the Src homology 2 domain-containing protein (SH2D1A) or signaling lymphocyte activation molecule (SLAM)-associated protein (SAP), which may function as regulators of NK 2B4-associated signal transduction pathways. NK 2B4 is expressed in human spleen, peripheral blood leukocytes, lymph node, bone marrow and fetal liver.

Function:
CD244 (2b4) is expressed on all human NK cells, a subpopulation of T cells, basophils and monocytes. CD244 activates NK cell mediated cytotoxicity, induces secretion of IFN-gamma and matrix metalloproteinases, and NK cell invasiveness. Although there have been several molecules shown to interact with CD244, the signaling mechanism ofCD244-mediated activation of NK cells is still unknown. It is a high affinity receptor for CD48.

Subcellular Location:
Cell Membrane; single-pass type I membrane protein

SWISS:
Q9BZW8

Gene ID:
51744

Database links:

Entrez Gene: 51744 Human

Omim: 605554 Human

SwissProt: Q9BZW8 Human

Unigene: 157872 Human



產品圖片
Sample: Lane 1: Human THP-1 cell lysates Lane 2: Human HL60 cell lysates Primary: Anti-NKR2B4 (bs-13776R) at 1/1000 dilution Secondary: IRDye800CW Goat Anti-Rabbit IgG at 1/20000 dilution Predicted band size: 39 kD Observed band size: 75 kD
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