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CBX4 Rabbit pAb (bs-17376R)  
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產品編號 bs-17376R
英文名稱 CBX4 Rabbit pAb
中文名稱 染色盒同源物4抗體
別    名 CBX 4; CBX4_HUMAN; E3 SUMO-protein ligase CBX4; EC:2.3.2.-; Chromobox protein homolog 4; Polycomb 2 homolog(Pc2; hPc2); Pc2; hPc2;  
Specific References  (3)     |     bs-17376R has been referenced in 3 publications.
[IF=4.658] Hu C et al. CBX4 promotes the proliferation and metastasis via regulating BMI‐1 in lung cancer. J Cell Mol Med. 2019 Nov 13.  WB&IHC-P ;  Human&Mouse.  
[IF=4.011] Xu J et al. Regulatory effect of two Trichinella spiralis serine protease inhibitors on the host's immune system. Sci Rep. 2019 Nov 19;9(1):17045.  WB ;  Mouse.  
[IF=1.91] Han, Xiao, et al. "HIF-1α SUMOylation affects the stability and transcriptional activity of HIF-1α in human lens epithelial cells." Graefe's Archive for Clinical and Experimental Ophthalmology 253.8 (2015): 1279-1290.  WB ;  Human.  
研究領域 細胞生物  結合蛋白  表觀遺傳學  泛素  
抗體來源 Rabbit
克隆類型 Polyclonal
克 隆 號
交叉反應 Human,Mouse,Rat (predicted: Pig,Sheep,Dog,Horse)
產品應用 WB=1:500-2000,ICC/IF=1:100
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
理論分子量 61 kDa
檢測分子量
細胞定位 細胞核 
性    狀 Liquid
濃    度 1mg/ml
免 疫 原 KLH conjugated synthetic peptide derived from human CBX4: 401-500/560 
亞    型 IgG
純化方法 affinity purified by Protein A
緩 沖 液 0.01M TBS (pH7.4) with 1% BSA, 0.02% Proclin300 and 50% Glycerol.
保存條件 Shipped at 4℃. Store at -20℃ for one year. Avoid repeated freeze/thaw cycles.
注意事項 This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
PubMed PubMed
產品介紹 Enables SUMO binding activity; SUMO ligase activity; and enzyme binding activity. Involved in negative regulation of transcription by RNA polymerase II. Located in nuclear body. Part of PRC1 complex. Implicated in hepatocellular carcinoma. Biomarker of hepatocellular carcinoma. [provided by Alliance of Genome Resources, Apr 2022]

Function:
E3 SUMO-protein ligase which facilitates SUMO1 conjugation by UBE2I. Component of the Polycomb group (PcG) multiprotein PRC1 complex, a complex required to maintain the transcriptionally repressive state of many genes, including Hox genes, throughout development. PcG PRC1 complex acts via chromatin remodeling and modification of histones; it mediates monoubiquitination of histone H2A 'Lys-119', rendering chromatin heritably changed in its expressibility.

Subunit:
Interacts with histone H3-K9Me3. Interacts with CHTOP (By similarity). Component of a PRC1-like complex. Self-associates. Interacts with SUV39H1 and HIPK2. Interacts with CSNK2B.

Subcellular Location:
Nucleus.

Tissue Specificity:
Ubiquitous.

Post-translational modifications:
Phosphorylated on Thr-497 by HIPK2 upon DNA damage; which enhances E3 SUMO-protein ligase activity and promotes sumoylation on Lys-494.

Similarity:
Contains 1 chromo domain.

SWISS:
O00257

Gene ID:
8535

Database links:

Entrez Gene: 8535 Human

Entrez Gene: 12418 Mouse

Entrez Gene: 501403 Rat

SwissProt: O00257 Human

SwissProt: O55187 Mouse



產品圖片
Sample: Lane 1: Mouse Liver tissue lysates Lane 2: Rat Liver tissue lysates Lane 3: Human K562 cell lysates Lane 4: Human HL-60 cell lysates Lane 5: Human HeLa cell lysates Lane 6: Human HepG2 cell lysates Lane 7: Human HUVEC cell lysates Lane 8: Human A549 cell lysates Primary: Anti-CBX4 (bs-17376R) at 1/1000 dilution Secondary: IRDye800CW Goat Anti-Rabbit IgG at 1/20000 dilution Predicted band size: 61 kDa Observed band size: 61 kDa
Hela cell; 4% Paraformaldehyde-fixed; Triton X-100 at room temperature for 20 min; Blocking buffer (normal goat serum, C-0005) at 37°C for 20 min; Antibody incubation with (CBX4) polyclonal Antibody, Unconjugated (bs-17376R) 1:25, 90 minutes at 37°C; followed by a conjugated Goat Anti-Rabbit IgG antibody at 37°C for 90 minutes, DAPI (blue, C02-04002) was used to stain the cell nuclei.
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