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HAVCR2/TIM-3 Rabbit pAb (bs-8766R)  
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產(chǎn)品編號 bs-8766R
英文名稱 HAVCR2/TIM-3 Rabbit pAb
中文名稱 T淋巴細胞膜蛋白3(CD366)抗體
別    名 Hepatitis A virus cellular receptor 2 homolog; CD366; CD 366; TIM-3; HAVR2_MOUSE; Kidney injury molecule 3; KIM 3; KIM3; T cell immunoglobulin and mucin domain containing 3; T cell immunoglobulin mucin 3; T-cell immunoglobulin and mucin domain-containing protein 3; T-cell immunoglobulin mucin receptor 3; T-cell membrane protein 3; TIM3; TIMD-3; TIM 3; TIMD3.  
Specific References  (3)     |     bs-8766R has been referenced in 3 publications.
[IF=4.068] Li Wang. et al. Radiotherapy upregulated immune checkpoints contribute to the development of second primary OSCC. ORAL DIS. 2023 May;:  WB ;  Rat.  
[IF=3.743] Zhu G et al. ShenQi FuZheng Injection ameliorates fatigue-like behavior in mouse models of cancer-related fatigue. Biomed Pharmacother. 2019 Mar;111:1376-1382.  IHC ;  Mouse.  
[IF=3.542] Guo Y et al. Tim-3 exacerbates kidney ischaemia/reperfusion injury through the TLR-4/NF-κB signalling pathway and an NLR-C4 inflammasome activation. Clinical & Experimental Immunology,2018 193(1), 113–129.  IF ;  Mouse.  
研究領域 細胞生物  免疫學  淋巴細胞  t-淋巴細胞  細胞膜蛋白  
抗體來源 Rabbit
克隆類型 Polyclonal
克 隆 號
交叉反應 Human,Mouse
產(chǎn)品應用 WB=1:500-2000,ELISA=1:5000-10000
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
理論分子量 29 kDa
檢測分子量
細胞定位 細胞膜 
性    狀 Liquid
濃    度 1mg/ml
免 疫 原 KLH conjugated synthetic peptide derived from mouse HAVCR2: 151-250/281 <Extracellular>
亞    型 IgG
純化方法 affinity purified by Protein A
緩 沖 液 0.01M TBS (pH7.4) with 1% BSA, 0.02% Proclin300 and 50% Glycerol.
保存條件 Shipped at 4℃. Store at -20℃ for one year. Avoid repeated freeze/thaw cycles.
注意事項 This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
PubMed PubMed
產(chǎn)品介紹 The protein encoded by this gene belongs to the immunoglobulin superfamily, and TIM family of proteins. CD4-positive T helper lymphocytes can be divided into types 1 (Th1) and 2 (Th2) on the basis of their cytokine secretion patterns. Th1 cells are involved in cell-mediated immunity to intracellular pathogens and delayed-type hypersensitivity reactions, whereas, Th2 cells are involved in the control of extracellular helminthic infections and the promotion of atopic and allergic diseases. This protein is a Th1-specific cell surface protein that regulates macrophage activation, and inhibits Th1-mediated auto- and alloimmune responses, and promotes immunological tolerance. [provided by RefSeq, Sep 2011]

Function:
Regulates macrophage activation. Inhibits T-helper type 1 lymphocyte (Th1)-mediated auto- and alloimmune responses and promotes immunological tolerance. May be also involved in T-cell homing. Receptor for LGALS9.

Subcellular Location:
Membrane.

Tissue Specificity:
T-helper type 1 lymphocyte (Th1)-specific.

Post-translational modifications:
O-glycosylated with core 1 or possibly core 8 glycans.

Similarity:
Belongs to the immunoglobulin superfamily. TIM family.

Database links:

Entrez Gene: 171285 Mouse

SwissProt: Q8VIM0 Mouse

Unigene: 72168 Mouse



產(chǎn)品圖片
25 ug total protein per lane of various lysates (see on figure) probed with HAVCR2 polyclonal antibody, unconjugated (bs-8766R) at 1:1000 dilution and 4°C overnight incubation. Followed by conjugated secondary antibody incubation at r.t. for 60 min.
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