麻豆av资源_日本三级一区_www.狠狠艹_国产精妇在线观看第一区_成人性生交大片免费看中国A片_日本一本久久

掃碼關注公眾號           掃碼咨詢技術支持           掃碼咨詢技術服務
  
客服熱線:400-901-9800  客服QQ:4009019800  技術答疑  技術支持  質量反饋  關于我們  聯(lián)系我們
91视频在线视频,亚洲中文无码成人影院,91mv.cool在线观看
首頁 > 產品中心 > 一抗 > 產品信息
RNF111 Rabbit pAb (bs-10937R)  
訂購熱線:400-901-9800
訂購郵箱:sales@bioss.com.cn
訂購QQ:  400-901-9800
技術支持:techsupport@bioss.com.cn
50ul/1180.00元
100ul/1980.00元
200ul/2800.00元
大包裝/詢價

產品編號 bs-10937R
英文名稱 RNF111 Rabbit pAb
中文名稱 環(huán)指蛋白111抗體
別    名 ARK; Arkadia; DKFZp313E0731; DKFZp686H1966; DKFZp761D081; E3 ubiquitin protein ligase Arkadia; FLJ38008; Ring finger protein 111; RNF 111; RN111_HUMAN.  
研究領域 細胞生物  免疫學  信號轉導  生長因子和激素  泛素  
抗體來源 Rabbit
克隆類型 Polyclonal
克 隆 號
交叉反應 Mouse,Rat (predicted: Human,Rabbit,Sheep,Cow,Dog)
產品應用 IHC-P=1:100-500,IHC-F=1:100-500,IF=1:100-500
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
理論分子量 109 kDa
檢測分子量
細胞定位 細胞核 細胞漿 
性    狀 Liquid
濃    度 1mg/ml
免 疫 原 KLH conjugated synthetic peptide derived from human RNF111: 851-950/994 
亞    型 IgG
純化方法 affinity purified by Protein A
緩 沖 液 0.01M TBS (pH7.4) with 1% BSA, 0.02% Proclin300 and 50% Glycerol.
保存條件 Shipped at 4℃. Store at -20℃ for one year. Avoid repeated freeze/thaw cycles.
注意事項 This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
PubMed PubMed
產品介紹 The protein encoded by this gene is a nuclear RING-domain containing E3 ubiquitin ligase. This protein interacts with the transforming growth factor (TGF) -beta/NODAL signaling pathway by promoting the ubiquitination and proteosomal degradation of negative regulators, like SMAD proteins, and thereby enhances TGF-beta target-gene transcription. As a modulator of the nodal signaling cascade, this gene plays a critical role in the induction of mesoderm during embryonic development. Alternative splicing of this gene results in multiple transcript variants encoding distinct isoforms. [provided by RefSeq, Jul 2012]

Function:
Acts in the NODAL pathway of mesoderm patterning during embryonic development. Acts downstream AXIN1 as an E3 ubiquitin-protein ligase which promotes the ubiquitination of inhibitory SMADs such as SMAD7, induces their proteasomal degradation and thereby enhances the transcriptional activity of TGF-beta and BMP. Activates Smad3/Smad4-dependent transcription by triggering signal-induced SnoN degradation.

Subunit:
Interacts with SMAD6, SMAD7, AXIN1, AXIN2 and SKIL isoform SNON. Part of a complex containing RNF111, AXIN1 and SMAD7. Interacts (via SIM domains) with SUMO1 and SUMO2.

Subcellular Location:
Cytoplasmic and Nuclear

Tissue Specificity:
Broadly expressed.

Similarity:
Contains 1 RING-type zinc finger.

SWISS:
Q6ZNA4

Gene ID:
54778

Database links:

Entrez Gene: 54778 Human

Omim: 605840 Human

SwissProt: Q6ZNA4 Human

Unigene: 404423 Human



產品圖片
Paraformaldehyde-fixed, paraffin embedded (rat colon); Antigen retrieval by boiling in sodium citrate buffer (pH6.0) for 15min; Block endogenous peroxidase by 3% hydrogen peroxide for 20 minutes; Blocking buffer (normal goat serum) at 37°C for 30min; Antibody incubation with (RNF111) Polyclonal Antibody, Unconjugated (bs-10937R) at 1:200 overnight at 4°C, followed by operating according to SP Kit(Rabbit) (sp-0023) instructionsand DAB staining.
Paraformaldehyde-fixed, paraffin embedded (mouse cerebellum); Antigen retrieval by boiling in sodium citrate buffer (pH6.0) for 15min; Block endogenous peroxidase by 3% hydrogen peroxide for 20 minutes; Blocking buffer (normal goat serum) at 37°C for 30min; Antibody incubation with (RNF111) Polyclonal Antibody, Unconjugated (bs-10937R) at 1:200 overnight at 4°C, followed by operating according to SP Kit(Rabbit) (sp-0023) instructionsand DAB staining.
Paraformaldehyde-fixed, paraffin embedded (rat testis); Antigen retrieval by boiling in sodium citrate buffer (pH6.0) for 15min; Block endogenous peroxidase by 3% hydrogen peroxide for 20 minutes; Blocking buffer (normal goat serum) at 37°C for 30min; Antibody incubation with (RNF111) Polyclonal Antibody, Unconjugated (bs-10937R) at 1:200 overnight at 4°C, followed by operating according to SP Kit(Rabbit) (sp-0023) instructionsand DAB staining.
版權所有 2004-2026 m.jywcc.com 北京博奧森生物技術有限公司
通過國際質量管理體系ISO 9001:2015 GB/T 19001-2016    證書編號: 00124Q34771R2M/1100
通過國際醫(yī)療器械-質量管理體系ISO 13485:2016 GB/T 42061-2022    證書編號: CQC24QY10047R0M/1100
京ICP備05066980號-1         京公網安備110107000727號
主站蜘蛛池模板: 亚洲自偷自偷图片视频专区 | 国产又粗又大又硬点视频 | 99亚洲男女激情在线观看 | 999亚洲精品无码久久久久 | 国产四区视频 | 国产黑色丝袜在线播放 | 国产精品禁漫天堂视频 | 中文字幕熟妇在线观看 | 亚洲AV无码乱码在线观看野外 | 婷婷欧美一区二区三区 | 国产综合欧美 | 天天躁狠狠躁 | 色69av| 日韩免费无码视频一区二区三区 | 成熟女人色惰片免费视频 | 国产一区二区不卡在线看 | 91在线精品一区二区 | 麻豆免费在线视频 | 国产精品ⅴ无码大片在线看 | 乱人伦人妻中文字幕不卡 | 1000部啪啪未满十八勿入不卡 | 99热2| 欧美精品第一区 | 污污网站免费 | 日本久久综合视频 | 亚洲日韩成人无码不卡 | 不卡国产视频 | ririsao亚洲国产中文 | 久久综合狠狠色综合伊人 | 日韩国产精品视频 | 日本二区在线观看 | 男人扒开女人内裤强吻桶进去 | 麻豆国产免费 | 67PAO国产成视频永久免费 | 精选av| 亚洲欧美国产欧美色欲 | 亚洲VA在线VA天堂XXXX中文 | 97热久久免费频精品99 | 91精品国产综合久久久久久丝袜 | 三级视频在线观看 | 91久久精品夜夜躁日日躁欧美 |