麻豆av资源_日本三级一区_www.狠狠艹_国产精妇在线观看第一区_成人性生交大片免费看中国A片_日本一本久久

掃碼關注公眾號           掃碼咨詢技術支持           掃碼咨詢技術服務
  
客服熱線:400-901-9800  客服QQ:4009019800  技術答疑  技術支持  質量反饋  關于我們  聯系我們
免费在线看片网站,日本不卡一区二区三区,精品成人私密视频
首頁 > 產品中心 > 一抗 > 產品信息
CD31 Rabbit pAb (bs-20319R)  
訂購熱線:400-901-9800
訂購郵箱:sales@bioss.com.cn
訂購QQ:  400-901-9800
技術支持:techsupport@bioss.com.cn
50ul/1180.00元
100ul/1980.00元
200ul/2800.00元
大包裝/詢價

產品編號 bs-20319R
英文名稱 CD31 Rabbit pAb
中文名稱 血小板內皮細胞黏附分子-1抗體
別    名 platelet endothelial cell adhesion molecule precursor-1; PECAM-1; PECAM1; Adhesion molecule; CD31 antigen; CD31 EndoCAM; Endocam; FLJ34100; FLJ58394; GPIIA; Pecam 1; PECA1_HUMAN; PECAM 1 CD31 EndoCAM; PECA1; Pecam1; Platelet endothelial cell adhesion molecule; Platelet/endothelial cell adhesion molecule 1; Adhesion molecule; Platelet/endothelial cell adhesion molecule.  
Specific References  (1)     |     bs-20319R has been referenced in 1 publications.
[IF=4.784] Ding J et al. Anti-angiogenic effect of a chemically sulfated polysaccharide from Phellinus ribis by inhibiting VEGF/VEGFR pathway. Int J Biol Macromol. 2020 Mar 11;154:72-81.  IHC,WB ;  mouse.  
研究領域 腫瘤  心血管  細胞生物  免疫學  干細胞  細胞粘附分子  細胞表面分子  糖蛋白  血管內皮細胞  淋巴細胞  t-淋巴細胞  骨髓細胞  
抗體來源 Rabbit
克隆類型 Polyclonal
克 隆 號
交叉反應 Mouse,Rat (predicted: Human)
產品應用 WB=1:500-2000
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
理論分子量 78 kDa
檢測分子量
細胞定位 細胞膜 
性    狀 Liquid
濃    度 1mg/ml
免 疫 原 KLH conjugated synthetic peptide derived from human CD31: 501-600/738 <Extracellular>
亞    型 IgG
純化方法 affinity purified by Protein A
緩 沖 液 Preservative: 0.02% Proclin300, Constituents: 1% BSA, 0.01M PBS, pH7.4.
保存條件 Shipped at 4℃. Store at -20℃ for one year. Avoid repeated freeze/thaw cycles.
注意事項 This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
PubMed PubMed
產品介紹 The protein encoded by this gene is found on the surface of platelets, monocytes, neutrophils, and some types of T-cells, and makes up a large portion of endothelial cell intercellular junctions. The encoded protein is a member of the immunoglobulin superfamily and is likely involved in leukocyte migration, angiogenesis, and integrin activation. [provided by RefSeq, May 2010]

Function:
Induces susceptibility to atherosclerosis. Cell adhesion molecule which is required for leukocyte transendothelial migration (TEM) under most inflammatory conditions. Tyr-690 plays a critical role in TEM and is required for efficient trafficking of PECAM1 to and from the lateral border recycling compartment (LBRC) and is also essential for the LBRC membrane to be targeted around migrating leukocytes. Prevents phagocyte ingestion of closely apposed viable cells by transmitting 'detachment' signals, and changes function on apoptosis, promoting tethering of dying cells to phagocytes (the encounter of a viable cell with a phagocyte via the homophilic interaction of PECAM1 on both cell surfaces leads to the viable cell's active repulsion from the phagocyte. During apoptosis, the inside-out signaling of PECAM1 is somehow disabled so that the apoptotic cell does not actively reject the phagocyte anymore. The lack of this repulsion signal together with the interaction of the eat-me signals and their respective receptors causes the attachment of the apoptotic cell to the phagocyte, thus triggering the process of engulfment). Isoform Delta15 is unable to protect against apoptosis. Modulates BDKRB2 activation. Regulates bradykinin- and hyperosmotic shock-induced ERK1/2 activation in human umbilical cord vein cells (HUVEC).

Subunit:
Interacts with PTPN11; Tyr-713 is critical for PTPN11 recruitment. Forms a complex with BDKRB2 and GNAQ. Interacts with BDKRB2 and GNAQ.

Subcellular Location:
Isoform Long: Membrane; Single-pass type I membrane protein. Cell junction. Note=Localizes to the lateral border recycling compartment (LBRC) and recycles from the LBRC to the junction in resting endothelial cells.
Isoform Delta15: Cell junction. Note=Localizes to the lateral border recycling compartment (LBRC) and recycles from the LBRC to the junction in resting endothelial cells.

Tissue Specificity:
Expressed on platelets and leukocytes and is primarily concentrated at the borders between endothelial cells. Isoform Long predominates in all tissues examined. Isoform Delta12 is detected only in trachea. Isoform Delta14-15 is only detected in lung. Isoform Delta14 is detected in all tissues examined with the strongest expression in heart. Isoform Delta15 is expressed in brain, testis, ovary, cell surface of platelets, human umbilical vein endothelial cells (HUVECs), Jurkat T-cell leukemia, human erythroleukemia (HEL) and U937 histiocytic lymphoma cell lines (at protein level).

Post-translational modifications:
Phosphorylated on Ser and Tyr residues after cellular activation. Phosphorylated on tyrosine residues by FER and FES in response to FCER1 activation. In endothelial cells Fyn mediates mechanical-force (stretch or pull) induced tyrosine phosphorylation.

Similarity:
Contains 6 Ig-like C2-type (immunoglobulin-like) domains.

SWISS:
P16284

Gene ID:
5175

Database links:

Entrez Gene: 5175 Human

Omim: 173445 Human

SwissProt: P16284 Human

Unigene: 376675 Human

Unigene: 514412 Human



產品圖片
25 ug total protein per lane of various lysates (see on figure) probed with CD31 polyclonal antibody, unconjugated (bs-20319R) at 1:1000 dilution and 4°C overnight incubation. Followed by conjugated secondary antibody incubation at r.t. for 60 min.
版權所有 2004-2026 m.jywcc.com 北京博奧森生物技術有限公司
通過國際質量管理體系ISO 9001:2015 GB/T 19001-2016    證書編號: 00124Q34771R2M/1100
通過國際醫療器械-質量管理體系ISO 13485:2016 GB/T 42061-2022    證書編號: CQC24QY10047R0M/1100
京ICP備05066980號-1         京公網安備110107000727號
主站蜘蛛池模板: 国产超碰97| 在线观看人成视频免费不卡 | 国产黑丝美女av | 日韩大片在线永久观看视频网站免费 | 免费成人在线视频观看 | 日本一区二区三区在线免费观看 | 欧美大片aaaaa免费观看 | 亚洲精品国产精品国产自 | 激情97综合亚洲色婷婷五 | 这里只有精品在线观看 | 亚洲日韩AV无码中文字幕美国 | 国产福利酱国产一区二区 | 无遮挡高潮国产免费观看 | 久久国产精品一国产精品金尊 | 欧美视频在线观看不卡 | 亚洲熟妇久久精品 | 久久精品播放 | 亚洲精品视频大全 | 少妇被粗大的猛烈进出 | 亚洲精品国产综合久久一线 | 美女脱内衣禁止18以下看免费 | 国产精品无码AV不卡 | 国产精品日韩精品欧美精品 | 日韩精品在线免费播放 | 强行挺进朋友漂亮人妻身体 | 亚洲狠狠婷婷久久久四季av | 黄色免费观看视频网站 | gogogo免费视频观看 | 麻豆久久久久久 | 国产一国产二国产三国产四国产五 | 男生夜间福利免费网站 | 国产草莓精品国产av片国产 | 国产精品午夜在在线观看 | 中文字幕av久久波多野结 | 亚洲国产欧美自拍 | 91精品婷婷色在线观看 | 亚洲色大成网站WWW永久麻豆 | www.四虎网站 | 国产免费av在线 | 黄色激情网址 | 国产v欧美 |