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CCL27 Rabbit pAb (bs-20466R)  
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產品編號 bs-20466R
英文名稱 CCL27 Rabbit pAb
中文名稱 皮膚T細胞虜獲趨化因子抗體
別    名 ALP; CTACK; C-C motif chemokine 27; CC chemokine ILC; Ccl27; CTAK; Cutaneous T cell attracting chemokine; Cutaneous T-cell-attracting chemokine; ESkine; IL 11 R alpha locus chemokine; IL-11 R-alpha-locus chemokine; PESKY; SCYA27; Skinkine; Small inducible cytokine A27; Small-inducible cytokine A27.  
Specific References  (1)     |     bs-20466R has been referenced in 1 publications.
[IF=3.269] Mengxue Zhang. et al. Identification and validation of potential novel biomarkers for oral squamous cell carcinoma. Bioengineered. 2021;12(1):8845-8862  IF,IHC ;  Human,Mouse.  
研究領域 免疫學  趨化因子  
抗體來源 Rabbit
克隆類型 Polyclonal
克 隆 號
交叉反應 Human
產品應用 IHC-P=1:100-500,IHC-F=1:100-500,IF=1:100-500
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
理論分子量 19 kDa
檢測分子量
細胞定位 分泌型蛋白 
性    狀 Liquid
濃    度 1mg/ml
免 疫 原 KLH conjugated synthetic peptide derived from human CCL27: 26-100/112 
亞    型 IgG
純化方法 affinity purified by Protein A
緩 沖 液 Preservative: 0.02% Proclin300, Constituents: 1% BSA, 0.01M PBS, pH7.4.
保存條件 Shipped at 4℃. Store at -20℃ for one year. Avoid repeated freeze/thaw cycles.
注意事項 This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
PubMed PubMed
產品介紹 This gene is one of several CC cytokine genes clustered on the p-arm of chromosome 9. Cytokines are a family of secreted proteins involved in immunoregulatory and inflammatory processes. The CC cytokines are proteins characterized by two adjacent cysteines. The protein encoded by this gene is chemotactic for skin-associated memory T lymphocytes. This cytokine may also play a role in mediating homing of lymphocytes to cutaneous sites. It specifically binds to chemokine receptor 10 (CCR10). Studies of a similar murine protein indicate that these protein-receptor interactions have a pivotal role in T cell-mediated skin inflammation. [provided by RefSeq].

Function:
Chemotactic factor that attracts skin-associated memory T-lymphocytes. May play a role in mediating homing of lymphocytes to cutaneous sites. Binds to CCR10.

Subunit:
Monomer, dimer, and tetramer. Heparin avidly promotes oligomerization.

Subcellular Location:
Secreted.

Tissue Specificity:
Testis, thymus, placenta, ovary and skin.

Similarity:
Belongs to the intercrine beta (chemokine CC) family.

SWISS:
Q9Y4X3

Gene ID:
10850

Database links:

Entrez Gene: 10850 Human

Omim: 604833 Human

SwissProt: Q9Y4X3 Human



CCL27是一種CC型趨化因子,又被稱為Skinkine,ESkine和CTACK。CCL27基因位于人類染色體9,它與皮膚上歸巢的記憶T淋巴細胞有關,并在T細胞介導的皮膚炎癥中起著重要的作用。CCL27表達在許多組織,包括性腺,胸腺,胎盤和皮膚。其配體為CCR10,CCL27與接觸性軟疣病毒編碼產生的蛋白質MC148有較高的同源性,但卻與人皰疹病毒8型編碼產生病毒巨噬細胞炎癥蛋白-Ⅱ競爭結合受體CCR10。
產品圖片
Paraformaldehyde-fixed, paraffin embedded (Human prostate); Antigen retrieval by boiling in sodium citrate buffer (pH6.0) for 15min; Block endogenous peroxidase by 3% hydrogen peroxide for 20 minutes; Blocking buffer (normal goat serum) at 37°C for 30min; Antibody incubation with (CCL27) Polyclonal Antibody, Unconjugated (bs-20466R) at 1:400 overnight at 4°C, followed by a conjugated secondary (sp-0023) for 20 minutes and DAB staining.
Paraformaldehyde-fixed, paraffin embedded (Human stomach carcinoma); Antigen retrieval by boiling in sodium citrate buffer (pH6.0) for 15min; Block endogenous peroxidase by 3% hydrogen peroxide for 20 minutes; Blocking buffer (normal goat serum) at 37°C for 30min; Antibody incubation with (CCL27) Polyclonal Antibody, Unconjugated (bs-20466R) at 1:500 overnight at 4°C, followed by a conjugated secondary (sp-0023) for 20 minutes and DAB staining.
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