麻豆av资源_日本三级一区_www.狠狠艹_国产精妇在线观看第一区_成人性生交大片免费看中国A片_日本一本久久

掃碼關注公眾號           掃碼咨詢技術支持           掃碼咨詢技術服務
  
客服熱線:400-901-9800  客服QQ:4009019800  技術答疑  技術支持  質量反饋  關于我們  聯系我們
边摸边吃奶边做爰视频网站,免费一级特黄特色毛片久久看,国产日韩欧美亚洲
首頁 > 產品中心 > 一抗 > 產品信息
[KO驗證抗體] STAT3 Mouse mAb (bsm-33223M)  
訂購熱線:400-901-9800
訂購郵箱:sales@bioss.com.cn
訂購QQ:  400-901-9800
技術支持:techsupport@bioss.com.cn
50ul/1180.00元
100ul/1980.00元
200ul/2800.00元
200ug(PBS only)/5600.00元
大包裝/詢價

產品編號 bsm-33223M
英文名稱 [KO驗證抗體] STAT3 Mouse mAb
中文名稱 信號轉導和轉錄激活因子3單克隆抗體
別    名 1110034C02Rik; Acute Phase Response Factor; APRF; AW109958; DNA binding protein APRF; FLJ20882; HIES; MGC128731; MGC16063; MGC93551; Signal transducer and activator of transcription 3(acute-phase response factor); Signal transducer and activator of transcription 3; Signal Transductor and Activator of Transcription 3; STAT 3; Transcription factor; STAT3_HUMAN.  
Specific References  (7)     |     bsm-33223M has been referenced in 7 publications.
[IF=5.595] Zhao W et al. Long noncoding RNA NSCLCAT1 increases non-small cell lung cancer cell invasion and migration through the Hippo signaling pathway by interacting with CDH1.(2018)FASEB J. Aug 27  IHC ;  Human.  
[IF=5.546] Feng‐Feng Lv. et al. microRNA‐495 alleviates endothelial cell inflammatory injury in coronary heart disease via blockade of the NF‐κB pathway by targeting RALB. 2020 Aug 18  IHC ;  Mouse.  
[IF=3.923] Zhao Z et al.Protective role of microRNA-374 against myocardial ischemia-reperfusion injury in mice following thoracic epidural anesthesia by downregulating dystrobrevin alpha-mediated Notch1 axis.(2018)J Cell Physiol. Nov 22.  IHC ;  Mouse.  
[IF=3.287] Keliang Song. et al. Knocking down Siglec-15 in osteosarcoma cells inhibits proliferation while promoting apoptosis and pyroptosis by targeting the Siglec-15/STAT3/Bcl-2 pathway. ADV MED SCI-POLAND. Adv Med Sci-Poland. 2022 Sep;67:187  WB ;  Human.  
[IF=2.923] Taojie Zhang. et al. MEL regulates miR-21 and let-7b through the STAT3 cascade in the follicular granulosa cells of Tibetan sheep. THERIOGENOLOGY. 2023 Apr;:  IF ;  Sheep.  
[IF=2.559] Lin JC et al. MicroRNA-874 targeting SUFU involves in osteoblast proliferation and differentiation in osteoporosis rats through the Hedgehog signaling pathway.(2018)Biochem. Biophys. Res. Commun.Nov 17;506(1):194-203.  IHC ;  Rat.  
[IF=2.524] Wu Y et al. Silencing of RAD51AP1 suppresses epithelial–mesenchymal transition and metastasis in non‐small cell lung cancer. Thorac Cancer. 2019 Jul 17.  IHC-P ;  Human.  
研究領域 腫瘤  細胞生物  信號轉導  細胞凋亡  轉錄調節因子  
抗體來源 Mouse
克隆類型 Monoclonal
克 隆 號 5H4
交叉反應 Human,Mouse,Rat
產品應用 WB=1:500-2000,IHC-P=1:200-2000,IHC-F=1:200-2000,IF=1:200-2000
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
理論分子量 88 kDa
檢測分子量
細胞定位 細胞核 細胞漿 
性    狀 Liquid
濃    度 1mg/ml
免 疫 原 Recombinant human STAT3 Protein: 9-265/770 
亞    型 IgG
純化方法 affinity purified by Protein G
緩 沖 液 0.01M TBS (pH7.4) with 1% BSA, 0.02% Proclin300 and 50% Glycerol.
保存條件 Shipped at 4℃. Store at -20℃ for one year. Avoid repeated freeze/thaw cycles.
注意事項 This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
PubMed PubMed
產品介紹 The protein encoded by this gene is a member of the STAT protein family. In response to cytokines and growth factors, STAT family members are phosphorylated by the receptor associated kinases, and then form homo- or heterodimers that translocate to the cell nucleus where they act as transcription activators. This protein is activated through phosphorylation in response to various cytokines and growth factors including IFNs, EGF, IL5, IL6, HGF, LIF and BMP2. This protein mediates the expression of a variety of genes in response to cell stimuli, and thus plays a key role in many cellular processes such as cell growth and apoptosis. The small GTPase Rac1 has been shown to bind and regulate the activity of this protein. PIAS3 protein is a specific inhibitor of this protein. Three alternatively spliced transcript variants encoding distinct isoforms have been described. Gene Symbol: APRF; FLJ20882; HIES; MGC16063.

Subunit:
Forms a homodimer or a heterodimer with a related family member (at least STAT1). Interacts with IL31RA, NCOA1, PELP1, SIPAR, SOCS7, STATIP1 and TMF1. Interacts with HCV core protein. Interacts with IL23R in presence of IL23. Interacts (via SH2 domain) with NLK. Interacts with ARL2BP; the interaction is enhanced by LIF and JAK1 expression (By similarity). Interacts with KPNA4 and KPNA5; KPNA4 may be the primary mediator of nuclear import (By similarity). Interacts with CAV2; the interaction is increased on insulin-induced tyrosine phosphorylation of CAV2 and leads to STAT3 activation (By similarity). Interacts with ARL2BP; interaction is enhanced with ARL2. Interacts with NEK6 (By similarity). Binds to CDK9 when activated and nuclear. Interacts with BMX. Interacts with ZIPK/DAPK3. Interacts with PIAS3; the interaction occurs on stimulation by IL6, CNTF or OSM and inhibits the DNA binding activity of STAT3. In prostate cancer cells, interacts with STAT3 and promotes DNA binding activity of STAT3. Interacts with STMN3, antagonizing its microtubule-destabilizing activity.

Subcellular Location:
Cytoplasm. Nucleus. Note=Shuttles between the nucleus and the cytoplasm. Translocated into the nucleus upon tyrosine phosphorylation and dimerization, in response to signaling by activated FGFR1, FGFR2, FGFR3 or FGFR4. Constitutive nuclear presence is independent of tyrosine phosphorylation. Predominantly present in the cytoplasm without stimuli. Upon leukemia inhibitory factor (LIF) stimulation, accumulates in the nucleus. The complex composed of BART and ARL2 plays an important role in the nuclear translocation and retention of STAT3. Identified in a complex with LYN and PAG1.

Tissue Specificity:
Heart, brain, placenta, lung, liver, skeletal muscle, kidney and pancreas.

Similarity:
Belongs to the transcription factor STAT family.
Contains 1 SH2 domain.

SWISS:
P40763

Gene ID:
6774

Database links:

Entrez Gene: 6774 Human

Entrez Gene: 20848 Mouse

Entrez Gene: 25125 Rat

Omim: 102582 Human

SwissProt: P40763 Human

SwissProt: P42227 Mouse

SwissProt: P52631 Rat



Stat3在細胞分化、增殖、凋亡等方面有著重要生理作用。有學者認為:STAT-3對腫瘤有一定的抑制作用,由于其與腫瘤的關系較為密切,越來越受到人們的重視。
產品圖片
25 ug total protein per lane of various lysates (see on figure) probed with STAT3 monoclonal antibody, unconjugated (bsm-33223M) at 1:1000 dilution and 4°C overnight incubation. Followed by conjugated secondary antibody incubation at r.t. for 60 min.
25 ug total protein per lane of various lysates (see on figure) probed with STAT3 monoclonal antibody, unconjugated (bsm-33223M) at 1:1000 dilution and 4°C overnight incubation. Followed by conjugated secondary antibody incubation at r.t. for 60 min.
Paraformaldehyde-fixed, paraffin embedded Human Breast Cancer; Antigen retrieval by boiling in sodium citrate buffer (pH6.0) for 15 min; The section was incubated with STAT3 Monoclonal Antibody, Unconjugated (ascites of bsm-33223M) at 1:1500 overnight at 4°C, followed by conjugation to the bs-40296G-HRP and DAB (C-0010) staining.
Paraformaldehyde-fixed, paraffin embedded Human Kidney; Antigen retrieval by boiling in sodium citrate buffer (pH6.0) for 15 min; The section was incubated with STAT3 Monoclonal Antibody, Unconjugated (ascites of bsm-33223M) at 1:1500 overnight at 4°C, followed by conjugation to the bs-40296G-HRP and DAB (C-0010) staining.
Paraformaldehyde-fixed, paraffin embedded Human Cerebrum; Antigen retrieval by boiling in sodium citrate buffer (pH6.0) for 15 min; The section was incubated with STAT3 Monoclonal Antibody, Unconjugated (ascites of bsm-33223M) at 1:1500 overnight at 4°C, followed by conjugation to the bs-40296G-HRP and DAB (C-0010) staining.
Paraformaldehyde-fixed, paraffin embedded Human Liver; Antigen retrieval by boiling in sodium citrate buffer (pH6.0) for 15 min; The section was incubated with STAT3 Monoclonal Antibody, Unconjugated (ascites of bsm-33223M) at 1:1500 overnight at 4°C, followed by conjugation to the bs-40296G-HRP and DAB (C-0010) staining.
Paraformaldehyde-fixed, paraffin embedded Human Tonsil; Antigen retrieval by boiling in sodium citrate buffer (pH6.0) for 15 min; The section was incubated with STAT3 Monoclonal Antibody, Unconjugated (ascites of bsm-33223M) at 1:1500 overnight at 4°C, followed by conjugation to the bs-40296G-HRP and DAB (C-0010) staining.
Paraformaldehyde-fixed, paraffin embedded Human Colon Cancer; Antigen retrieval by boiling in sodium citrate buffer (pH6.0) for 15 min; The section was incubated with STAT3 Monoclonal Antibody, Unconjugated (ascites of bsm-33223M) at 1:1500 overnight at 4°C, followed by conjugation to the bs-40296G-HRP and DAB (C-0010) staining.
Paraformaldehyde-fixed, paraffin embedded Human Cervical Cancer; Antigen retrieval by boiling in sodium citrate buffer (pH6.0) for 15 min; The section was incubated with STAT3 Monoclonal Antibody, Unconjugated (ascites of bsm-33223M) at 1:1500 overnight at 4°C, followed by conjugation to the bs-40296G-HRP and DAB (C-0010) staining.
Paraformaldehyde-fixed, paraffin embedded Human Lung Cancer; Antigen retrieval by boiling in sodium citrate buffer (pH6.0) for 15 min; The section was incubated with STAT3 Monoclonal Antibody, Unconjugated (ascites of bsm-33223M) at 1:1500 overnight at 4°C, followed by conjugation to the bs-40296G-HRP and DAB (C-0010) staining.
版權所有 2004-2026 m.jywcc.com 北京博奧森生物技術有限公司
通過國際質量管理體系ISO 9001:2015 GB/T 19001-2016    證書編號: 00124Q34771R2M/1100
通過國際醫療器械-質量管理體系ISO 13485:2016 GB/T 42061-2022    證書編號: CQC24QY10047R0M/1100
京ICP備05066980號-1         京公網安備110107000727號
主站蜘蛛池模板: 特级淫片日本高清视频免费 | 欧美综合天天夜夜久久 | 久久精品中文字幕女同 | 青娱乐极品视觉盛宴国产视频 | 国产亚洲综合久久系列 | 91久久久精品无码一区二 | 中文字幕亚洲天堂 | 成年人免费看片 | 91手机在线看片 | 欧美一二三区精品 | 511yc影院免费理论片 | 国产精品午夜福利在线观看地址 | 国产老熟女久久久 | 一区二区三区国产精华 | 国语自产拍在线观看对白 | 亚洲国产一二三区蜜臀在线 | 精品久久伊人99热超碰 | 熟妇人妻系列aⅴ无码专区友真希 | 国语自产精品视频在线播放 | 九一天堂 | 国产精品天码无卡在线观看 | 欧美日韩免费在线观看 | 中文字幕日产乱码六区 | 国产免费av国片精品草莓男男 | 国产亚洲综合AA系列 | 爱操成人 | 爱爱爱av| 久久精品国产综合精品 | 亚洲精品无码专区在线播放 | 精品av在线播放 | 成人av1234567| 一本一本久久aa综合精品 | 色婷婷亚洲婷婷7月 | 人人干人人爱人人爱 | 中文字幕久久久人伦 | 狠日狠干日日射 | 欧美香蕉 | 毛片毛片毛片毛片毛片毛片小 | 国产五码一区 | 337p日本欧洲亚洲大胆艺术96 | 特级淫片日本高清视频免费 |