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TIMP-1 Mouse mAb (bsm-10895M)  
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50ul/1180.00元
100ul/1980.00元
200ul/2800.00元
200ug(PBS only)/5600.00元
大包裝/詢價

產品編號 bsm-10895M
英文名稱 TIMP-1 Mouse mAb
中文名稱 金屬蛋白酶組織抑制因子-1單克隆抗體
別    名 Clgi; Collagenase inhibitor; EPA; EPO; Erythroid Potentiating Activity; Fibroblast collagenase inhibitor; FLJ90373; HC; Human Collagenase Inhibitor; Metalloproteinase inhibitor 1; Metalloproteinase inhibitor 1 precursor; OTTHUMP00000023214; TIMP 1; TIMP; TIMP metallopeptidase inhibitor 1; TIMP1 protein; Tissue Inhibitor of Metalloproteinase 1; Tissue inhibitor of metalloproteinases; Ttissue inhibitor of metalloproteinase 1 erythroid potentiating activity collagenase inhibitor.  
Specific References  (2)     |     bsm-10895M has been referenced in 2 publications.
[IF=5.714] Yipeng Wan. et al. Ursolic acid alleviates Kupffer cells pyroptosis in liver fibrosis by the NOX2/NLRP3 inflammasome signaling pathway. INT IMMUNOPHARMACOL. 2022 Dec;113:109321  WB ;  Mouse.  
[IF=3.801] M Li. et al. Histology‐based profile of inflammatory mediators in experimentally induced pulpitis in a rat model: screening for possible biomarkers. 2021 Mar 14  IF ;  Rat.  
研究領域 腫瘤  細胞生物  神經生物學  細胞凋亡  生長因子和激素  激酶和磷酸酶  合成與降解  
抗體來源 Mouse
克隆類型 Monoclonal
克 隆 號 4C2
交叉反應 Human
產品應用 Flow-Cyt=1ug/Test,ICC/IF=1:50-200
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
理論分子量 21 kDa
檢測分子量
細胞定位 分泌型蛋白 
性    狀 Liquid
濃    度 1mg/ml
免 疫 原 Recombinant human TIMP-1 
亞    型 IgG
純化方法 affinity purified by Protein G
緩 沖 液 0.01M TBS (pH7.4) with 1% BSA, 0.02% Proclin300 and 50% Glycerol.
保存條件 Shipped at 4℃. Store at -20℃ for one year. Avoid repeated freeze/thaw cycles.
注意事項 This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
PubMed PubMed
產品介紹 This gene belongs to the TIMP gene family. The proteins encoded by this gene family are natural inhibitors of the matrix metalloproteinases (MMPs), a group of peptidases involved in degradation of the extracellular matrix. In addition to its inhibitory role against most of the known MMPs, the encoded protein is able to promote cell proliferation in a wide range of cell types, and may also have an anti-apoptotic function. Transcription of this gene is highly inducible in response to many cytokines and hormones. In addition, the expression from some but not all inactive X chromosomes suggests that this gene inactivation is polymorphic in human females. This gene is located within intron 6 of the synapsin I gene and is transcribed in the opposite direction. [provided by RefSeq].

Function:
Complexes with metalloproteinases (such as collagenases) and irreversibly inactivates them by binding to their catalytic zinc cofactor. Also mediates erythropoiesis in vitro; but, unlike IL-3, it is species-specific, stimulating the growth and differentiation of only human and murine erythroid progenitors. Known to act on MMP-1, MMP-2, MMP-3, MMP-7, MMP-8, MMP-9, MMP-10, MMP-11, MMP-12, MMP-13 and MMP-16. Does not act on MMP-14.

Subcellular Location:
Secreted.

Post-translational modifications:
The activity of TIMP1 is dependent on the presence of disulfide bonds.

Similarity:
Belongs to the protease inhibitor I35 (TIMP) family.
Contains 1 NTR domain.

SWISS:
P01033

Gene ID:
7076

Database links:

Entrez Gene: 7076 Human

Entrez Gene: 21857 Mouse

Omim: 305370 Human

SwissProt: P01033 Human

SwissProt: P12032 Mouse

Unigene: 522632 Human

Unigene: 8245 Mouse



產品圖片
Sample: Lane 1: Mouse Stomach tissue lysates Lane 2: Mouse Lung tissue lysates Lane 3: Rat Stomach tissue lysates Lane 4: Rat Colon tissue lysates Lane 5: Rat Lung tissue lysates Primary: Anti-TIMP-1 (bsm-10895M) at 1/1000 dilution Secondary: IRDye800CW Goat Anti-Mouse IgG at 1/20000 dilution Predicted band size: 21 kDa Observed band size: 28 kDa
Paraformaldehyde-fixed, paraffin embedded (Mouse pancreas); Antigen retrieval by boiling in sodium citrate buffer (pH6.0) for 15min; Block endogenous peroxidase by 3% hydrogen peroxide for 20 minutes; Blocking buffer (normal goat serum) at 37°C for 30min; Antibody incubation with (TIMP-1) Monoclonal Antibody, Unconjugated (bsm-10895M) at 1:400 overnight at 4°C, followed by operating according to SP Kit(Mouse) (sp-0024) instructionsand DAB staining.
Paraformaldehyde-fixed, paraffin embedded (Human colon carcinoma); Antigen retrieval by boiling in sodium citrate buffer (pH6.0) for 15min; Block endogenous peroxidase by 3% hydrogen peroxide for 20 minutes; Blocking buffer (normal goat serum) at 37°C for 30min; Antibody incubation with (TIMP-1) Monoclonal Antibody, Unconjugated (bsm-10895M) at 1:400 overnight at 4°C, followed by operating according to SP Kit(Mouse) (sp-0024) instructionsand DAB staining.
Paraformaldehyde-fixed, paraffin embedded (Mouse brain); Antigen retrieval by boiling in sodium citrate buffer (pH6.0) for 15min; Block endogenous peroxidase by 3% hydrogen peroxide for 20 minutes; Blocking buffer (normal goat serum) at 37°C for 30min; Antibody incubation with (TIMP-1) Monoclonal Antibody, Unconjugated (bsm-10895M) at 1:400 overnight at 4°C, followed by operating according to SP Kit(Mouse) (sp-0024) instructionsand DAB staining.
Paraformaldehyde-fixed, paraffin embedded (Rat brain); Antigen retrieval by boiling in sodium citrate buffer (pH6.0) for 15min; Block endogenous peroxidase by 3% hydrogen peroxide for 20 minutes; Blocking buffer (normal goat serum) at 37°C for 30min; Antibody incubation with (TIMP-1) Monoclonal Antibody, Unconjugated (bsm-10895M) at 1:400 overnight at 4°C, followed by operating according to SP Kit(Mouse) (sp-0024) instructionsand DAB staining.
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