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Nkx2.6 Rabbit pAb (bs-24101R)  
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產品編號 bs-24101R
英文名稱 Nkx2.6 Rabbit pAb
中文名稱 轉錄因子同源蛋白Nkx2.6抗體
別    名 CSX2; Homeobox protein NK-2 homolog F; homeobox protein NK2 homolog F; Homeobox protein Nkx-2.6; Homeobox protein Nkx2.6; NK2 homeobox 6; NK2 transcription factor related, locus 6(Drosophila); NKX2-6; NKX26_MOUSE; NKX2F; NKX4 2; Tinman paralog.  
研究領域 心血管  細胞生物  發育生物學  轉錄調節因子  表觀遺傳學  
抗體來源 Rabbit
克隆類型 Polyclonal
克 隆 號
交叉反應 (predicted: Mouse)
產品應用 IHC-P=1:100-500,IHC-F=1:100-500,IF=1:100-500,ICC/IF=1:100-500
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
理論分子量 32 kDa
檢測分子量
細胞定位 細胞核 
性    狀 Liquid
濃    度 1mg/ml
免 疫 原 KLH conjugated synthetic peptide derived from mouse Nkx2.6: 1-100/289 
亞    型 IgG
純化方法 affinity purified by Protein A
緩 沖 液 0.01M TBS (pH7.4) with 1% BSA, 0.02% Proclin300 and 50% Glycerol.
保存條件 Shipped at 4℃. Store at -20℃ for one year. Avoid repeated freeze/thaw cycles.
注意事項 This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
PubMed PubMed
產品介紹 This gene encodes a homeobox-containing protein that belongs to the NK-2 homeobox family. This protein is a vertebrate homolog of Drosophila homeobox-containing protein called 'tinman', which has been shown to be essential for development of the heart-like dorsal vessel. In conjunction with related gene, NKX2-5, this gene may play a role in both pharyngeal and cardiac embryonic development. Mutations in this gene are associated with persistent truncus arteriosus.[provided by RefSeq, Aug 2011]

Function:
In conjunction with NKX2-5, may play a role in both pharyngeal and cardiac embryonic development.

Subcellular Location:
Nucleus

DISEASE:
A group of congenital heart defects involving the outflow tracts. Examples include truncus arteriosus communis, double-outlet right ventricle and transposition of great arteries. Truncus arteriosus communis is characterized by a single outflow tract instead of a separate aorta and pulmonary artery. In transposition of the great arteries, the aorta arises from the right ventricle and the pulmonary artery from the left ventricle. In double outlet of the right ventricle, both the pulmonary artery and aorta arise from the right ventricle.

Similarity:
Belongs to the NK-2 homeobox family. Contains 1 homeobox DNA-binding domain.

SWISS:
P43688

Gene ID:
18092

Database links:

Entrez Gene: 137814 Human

Entrez Gene: 18092 Mouse

Omim: 611770 Human

SwissProt: A6NCS4 Human

SwissProt: P43688 Mouse

Unigene: 532654 Human



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