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CD24 Rabbit pAb (bs-23867R)  
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產品編號 bs-23867R
英文名稱 CD24 Rabbit pAb
中文名稱 CD24抗體
別    名 CD 24; CD24; CD24 antigen(small cell lung carcinoma cluster 4 antigen); CD24 antigen; CD24 molecule; CD24_HUMAN; CD24A; GPI linked surface mucin; Heat stable antigen; HSA; Nectadrin; Signal transducer CD24; Small cell lung carcinoma cluster 4 antigen; Cd24; Cd24a; Ly-52.  
研究領域 腫瘤  細胞生物  免疫學  神經生物學  信號轉導  干細胞  細胞粘附分子  糖蛋白  細胞類型標志物  t-淋巴細胞  b-淋巴細胞  骨髓細胞  
抗體來源 Rabbit
克隆類型 Polyclonal
克 隆 號
交叉反應 Human,Mouse,Rat
產品應用 WB=1:500-2000
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
理論分子量 3/8 kDa
檢測分子量
細胞定位 細胞膜 
性    狀 Liquid
濃    度 1mg/ml
免 疫 原 KLH conjugated synthetic peptide derived from human CD24 : 35-80/80 
亞    型 IgG
純化方法 affinity purified by Protein A
緩 沖 液 0.01M TBS (pH7.4) with 1% BSA, 0.02% Proclin300 and 50% Glycerol.
保存條件 Shipped at 4℃. Store at -20℃ for one year. Avoid repeated freeze/thaw cycles.
注意事項 This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
PubMed PubMed
產品介紹 This gene encodes a sialoglycoprotein that is expressed on mature granulocytes and B cells and modulates growth and differentiation signals to these cells. The precursor protein is cleaved to a short 32 amino acid mature peptide which is anchored via a glycosyl phosphatidylinositol (GPI) link to the cell surface. This gene was missing from previous genome assemblies, but is properly located on chromosome 6. Non-transcribed pseudogenes have been designated on chromosomes 1, 15, 20, and Y. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Apr 2014]

Function:
Modulates B-cell activation responses. Signaling could be triggered by the binding of a lectin-like ligand to the CD24 carbohydrates, and transduced by the release of second messengers derived from the GPI-anchor. Promotes AG-dependent proliferation of B-cells, and prevents their terminal differentiation into antibody-forming cells.

Subcellular Location:
Cell membrane; Lipid-anchor, GPI-anchor.

Tissue Specificity:
B-cells. Expressed in a number of B-cell lines including P32/SH and Namalwa. Expressed in erythroleukemia cell and small cell lung carcinoma cell lines. Also expressed on the surface of T-cells.

DISEASE:
Genetic variations in CD24 are associated with susceptibility to multiple sclerosis (MS) [MIM:126200]. A multifactorial, inflammatory, demyelinating disease of the central nervous system. Sclerotic lesions are characterized by perivascular infiltration of monocytes and lymphocytes and appear as indurated areas in pathologic specimens (sclerosis in plaques). The pathological mechanism is regarded as an autoimmune attack of the myelin sheat, mediated by both cellular and humoral immunity. Clinical manifestations include visual loss, extra-ocular movement disorders, paresthesias, loss of sensation, weakness, dysarthria, spasticity, ataxia and bladder dysfunction. Genetic and environmental factors influence susceptibility to the disease. Note=Polymorphisms in CD24 may act as a genetic modifier for susceptibility and progression of MS in some populations, perhaps by affecting the efficiency of CD24 expression on the cell surface.

Similarity:
Belongs to the CD24 family.

SWISS:
P25063

Gene ID:
100133941

Database links:

Entrez Gene: 100133941 Human

Entrez Gene: 12484 Mouse

Entrez Gene: 25145 Rat

Omim: 600074 Human

SwissProt: P25063 Human

SwissProt: P24807 Mouse

SwissProt: Q07490 Rat

Unigene: 644105 Human

Unigene: 721443 Human

Unigene: 29742 Mouse

Unigene: 6007 Rat



神經干細胞標志物 腫瘤標志物 CD24是一種低分子質量高度糖基化的黏附分子, 主要表達在造血系統. 最近研究表明, 在造血系統腫瘤和一些器官的實體瘤表面可見CD24高表達。近幾年很多學者認為:CD24在前列腺癌、非小細胞肺癌、鼻咽癌、原發性肝細胞癌、膽管細胞癌、麥克爾細胞癌、神經源性腫瘤、胰腺癌、胃癌、結腸癌、腎細胞癌、B細胞淋巴瘤、乳腺癌等腫瘤組織中表達增強, 且和腫瘤侵襲轉移、復發和預后相關。
產品圖片
Sample: Lane 1: Kidney (Mouse) Lysate at 40 ug Lane 2: Cerebrum (Mouse) Lysate at 40 ug Lane 3: Kidney (Rat) Lysate at 40 ug Lane 4: Cerebrum (Rat) Lysate at 40 ug Primary: Anti- CD24 (bs-23867R) at 1/1000 dilution Secondary: IRDye800CW Goat Anti-Rabbit IgG at 1/20000 dilution Predicted band size: 35 kD Observed band size: 35 kD
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