麻豆av资源_日本三级一区_www.狠狠艹_国产精妇在线观看第一区_成人性生交大片免费看中国A片_日本一本久久

掃碼關注公眾號           掃碼咨詢技術支持           掃碼咨詢技術服務
  
客服熱線:400-901-9800  客服QQ:4009019800  技術答疑  技術支持  質量反饋  關于我們  聯系我們
91视频在线视频,精品无码国产自产在线观看水浒传,欧美成人一区二区三区在线观看
首頁 > 產品中心 > 一抗 > 產品信息
CD45 Mouse mAb (bsm-30095M)  
訂購熱線:400-901-9800
訂購郵箱:sales@bioss.com.cn
訂購QQ:  400-901-9800
技術支持:techsupport@bioss.com.cn
100ug/1880.00元
200ug(PBS only)/5600.00元
大包裝/詢價

產品編號 bsm-30095M
英文名稱 CD45 Mouse mAb
中文名稱 小鼠抗人CD45單克隆抗體
別    名 B220; CD 45; CD-45; cd45 antigen; ec3.1.3.48; CD45R; GP180; GP180; GP 180; L CA; LCA; L-CA; Leukocyte common antigen; LY5; Ly-5 glycoprotein; Protein tyrosine phosphatase receptor type C; Protein tyrosine phosphatase receptor type c polypeptide; protein tyrosine phosphatase, receptor type, C; Receptor-type tyrosine-protein phosphatase C; PTPRC; PTPRC_HUMAN; SCID due to PTPRC deficiency; T200; T200 glycoprotein; T200 leukocyte common antigen; Human homolog of severe combined immunodeficiency due to PTPRC deficiency.  
研究領域 細胞生物  免疫學  信號轉導  細胞表面分子  糖蛋白  淋巴細胞  
抗體來源 Mouse
克隆類型 Monoclonal
克 隆 號 HI30
交叉反應 Human
產品應用 Flow-Cyt=1ug/Test
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
理論分子量 143 kDa
檢測分子量 180-220
細胞定位 細胞膜 
性    狀 Liquid
濃    度 1mg/ml
免 疫 原 Recombinant human CD45 
亞    型 Mouse IgG1, k
純化方法 affinity purified by Protein G
緩 沖 液 0.01M TBS (pH7.4).
保存條件 Shipped at 4℃. Store at -20℃ for one year. Avoid repeated freeze/thaw cycles.
注意事項 This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
PubMed PubMed
產品介紹 The protein encoded by this gene is a member of the protein tyrosine phosphatase (PTP) family. PTPs are known to be signaling molecules that regulate a variety of cellular processes including cell growth, differentiation, mitotic cycle, and oncogenic transformation. This PTP contains an extracellular domain, a single transmembrane segment and two tandem intracytoplasmic catalytic domains, and thus belongs to receptor type PTP. This gene is specifically expressed in hematopoietic cells. This PTP has been shown to be an essential regulator of T- and B-cell antigen receptor signaling. It functions through either direct interaction with components of the antigen receptor complexes, or by activating various Src family kinases required for the antigen receptor signaling. This PTP also suppresses JAK kinases, and thus functions as a regulator of cytokine receptor signaling. Four alternatively spliced transcripts variants of this gene, which encode distinct isoforms, have been reported. [provided by RefSeq, Jul 2008].

Function:
Protein tyrosine-protein phosphatase required for T-cell activation through the antigen receptor. Acts as a positive regulator of T-cell coactivation upon binding to DPP4. The first PTPase domain has enzymatic activity, while the second one seems to affect the substrate specificity of the first one. Upon T-cell activation, recruits and dephosphorylates SKAP1 and FYN. Dephosphorylates LYN, and thereby modulates LYN activity.

Subunit:
Binds GANAB and PRKCSH. Interacts with SKAP1. Interacts with DPP4; the interaction is enhanced in a interleukin-12-dependent manner in activated lymphocytes. Contains 2 tyrosine-protein phosphatase domains.

Subcellular Location:
Membrane; Single-pass type I membrane protein. Membrane raft. Note=Colocalized with DPP4 in membrane rafts.

Post-translational modifications:
Heavily N- and O-glycosylated.

DISEASE:
Defects in PTPRC are a cause of severe combined immunodeficiency autosomal recessive T-cell-negative/B-cell-positive/NK-cell-positive (T(-)B(+)NK(+) SCID) [MIM:608971]. A form of severe combined immunodeficiency (SCID), a genetically and clinically heterogeneous group of rare congenital disorders characterized by impairment of both humoral and cell-mediated immunity, leukopenia, and low or absent antibody levels. Patients present in infancy recurrent, persistent infections by opportunistic organisms. The common characteristic of all types of SCID is absence of T-cell-mediated cellular immunity due to a defect in T-cell development.
Genetic variations in PTPRC are involved in multiple sclerosis susceptibility (MS) [MIM:126200]. MS is a neurodegenerative disorder characterized by the gradual accumulation of focal plaques of demyelination particularly in the periventricular areas of the brain. Peripheral nerves are not affected. Onset usually in third or fourth decade with intermittent progression over an extended period. The cause is still uncertain.

Similarity:
Belongs to the protein-tyrosine phosphatase family. Receptor class 1/6 subfamily.
Contains 2 fibronectin type-III domains.
Contains 2 tyrosine-protein phosphatase domains.

SWISS:
P08575

Gene ID:
5788

Database links:

Entrez Gene: 5788 Human

Entrez Gene: 19264 Mouse

Entrez Gene: 24699 Rat

Omim: 151460 Human

SwissProt: P08575 Human

SwissProt: P06800 Mouse

SwissProt: P04157 Rat

Unigene: 654514 Human

Unigene: 391573 Mouse

Unigene: 90166 Rat



產品圖片
Blank control: Molt4. Primary Antibody (green line): Mouse Anti-CD45 antibody (bsm-30095M) Dilution: 1μg /10^6 cells; Isotype Control Antibody (orange line): Mouse IgG . Secondary Antibody : Goat anti-mouse IgG-AF488 Dilution: 1μg /test. Protocol The cells were incubated in 5%BSA to block non-specific protein-protein interactions for 30 min at room temperature .Cells stained with Primary Antibody for 30 min at room temperature. The secondary antibody used for 40 min at room temperature. Acquisition of 20,000 events was performed.
版權所有 2004-2026 m.jywcc.com 北京博奧森生物技術有限公司
通過國際質量管理體系ISO 9001:2015 GB/T 19001-2016    證書編號: 00124Q34771R2M/1100
通過國際醫療器械-質量管理體系ISO 13485:2016 GB/T 42061-2022    證書編號: CQC24QY10047R0M/1100
京ICP備05066980號-1         京公網安備110107000727號
主站蜘蛛池模板: 天天做天天爱天天综合网2021 | 国产精品永久免费嫩草研究院 | 色在线免费观看 | 开心婷婷中文字幕 | 97人洗澡人人澡人人爽人人模 | 97热视频在线 | 国产全黄a一级毛片91 | 99久久国产综合麻豆99久久 | 老版包青天83版在线观看 | 超碰97人人做人人爱网站 | 在线观看av资源 | 欧美成aⅴ人高清三级 | 在线免费观看成人网 | 操操操日日日 | 丰满饥渴老妇人大黄毛片hd | 噼里啪啦免费观看高清动漫 | 国产精品对白一区二区三区 | 国精品无码一区二区三区在线蜜臀 | 午夜精品久久久久久久99婷婷 | 欧美一级特黄aaaaaaa在线观看 | 亚洲乱妇| 国产精品国语刺激对白在线观看 | 国产成人无码网站 | 国产系列精品av | 精品国产99高清一区二区三区 | 美女视频一级片 | 午夜寂寞视频无码专区 | 黄色一级片免费的 | 手机在线观看黄色网址 | 性xxxxxx| 超碰免费在线播放 | 97视频入口 | 国产一区二区亚洲 | 亚洲国产黄色 | 亚洲精品无码av久久久久久 | 伊人久久久综合 | 图片小说校园激情都市 | 爆乳熟妇一区二区三区 | 欧美一日本 | 国产在线一区二区三区四区 | 久久精品国产一区二区三区肥胖 |