麻豆av资源_日本三级一区_www.狠狠艹_国产精妇在线观看第一区_成人性生交大片免费看中国A片_日本一本久久

掃碼關注公眾號           掃碼咨詢技術支持           掃碼咨詢技術服務
  
客服熱線:400-901-9800  客服QQ:4009019800  技術答疑  技術支持  質量反饋  關于我們  聯系我們
中日韩一区二区,人伦人与牲囗免费观看,九色精品国产
首頁 > 產品中心 > 一抗 > 產品信息
P63(ready to use) Mouse mAb (BH0150)  
訂購熱線:400-901-9800
訂購郵箱:sales@bioss.com.cn
訂購QQ:  400-901-9800
技術支持:techsupport@bioss.com.cn
3ml/560.00元
6ml/980.00元
大包裝/詢價

產品編號 BH0150
英文名稱 P63(ready to use) Mouse mAb
中文名稱 腫瘤抑制基因p63單克隆抗體(工作液)
別    名 P63_HUMAN; Tumor protein 63; TP63; Chronic ulcerative stomatitis protein(CUSP); Keratinocyte transcription factor KET; Transformation-related protein 63(TP63); Tumor protein p73-like(p73L); p40; p51; KET; P63; P73H; P73L; TP73L; AIS; LMS; NBP; RHS; p40; p51; EEC3; OFC8; SHFM4; TP53L; p53CP; TP53CP; B(p51A); B(p51B); P51A; TAp63gamma; P51B; TAp63alpha; P51delta; TAp63delta; P51delNalpha; deltaNp63 alpha; P51delNbeta; deltaNp63 beta; P51delNgamma; deltaNp63gamma; p40-deltaNp63; p40-deltaNp63;  
研究領域 腫瘤  細胞生物  免疫學  信號轉導  轉錄調節因子  
抗體來源 Mouse
克隆類型 Monoclonal
克 隆 號 3C9
交叉反應 Human
產品應用
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
理論分子量 77 kDa
檢測分子量
細胞定位 細胞核 
性    狀 Liquid
免 疫 原 KLH conjugated synthetic peptide derived from human P63 
亞    型 IgG1
純化方法 affinity purified by Protein G
緩 沖 液 0.01M PBS (pH7.4) with 1% BSA and 0.02% Proclin300.
保存條件 Store at 2-8℃ for one year. Avoid repeated freeze/thaw cycles.
注意事項 This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
PubMed PubMed
產品介紹 This gene encodes a member of the p53 family of transcription factors. An animal model, p63 -/- mice, has been useful in defining the role this protein plays in the development and maintenance of stratified epithelial tissues. p63 -/- mice have several developmental defects which include the lack of limbs and other tissues, such as teeth and mammary glands, which develop as a result of interactions between mesenchyme and epithelium. Mutations in this gene are associated with ectodermal dysplasia, and cleft lip/palate syndrome 3 (EEC3); split-hand/foot malformation 4 (SHFM4); ankyloblepharon-ectodermal defects-cleft lip/palate; ADULT syndrome (acro-dermato-ungual-lacrimal-tooth); limb-mammary syndrome; Rap-Hodgkin syndrome (RHS); and orofacial cleft 8. Both alternative splicing and the use of alternative promoters results in multiple transcript variants encoding different proteins. Many transcripts encoding different proteins have been reported but the biological validity and the full-length nature of these variants have not been determined. [provided by RefSeq, Jul 2008].

Function:
Acts as a sequence specific DNA binding transcriptional activator or repressor. The isoforms contain a varying set of transactivation and auto-regulating transactivation inhibiting domains thus showing an isoform specific activity. May be required in conjunction with TP73/p73 for initiation of p53/TP53 dependent apoptosis in response to genotoxic insults and the presence of activated oncogenes. Involved in Notch signaling by probably inducing JAG1 and JAG2. Plays a role in the regulation of epithelial morphogenesis. The ratio of DeltaN-type and TA*-type isoforms may govern the maintenance of epithelial stem cell compartments and regulate the initiation of epithelial stratification from the undifferentiated embryonal ectoderm. Required for limb formation from the apical ectodermal ridge.

Subunit:
Binds DNA as a homotetramer. Isoform composition of the tetramer may determine transactivation activity. Isoforms Alpha and Gamma interact with HIPK2. Interacts with SSRP1, leading to stimulate coactivator activity. Isoform 1 and isoform 2 interact with WWP1. Interacts with PDS5A. Isoform 5 (via activation domain) interacts with NOC2L.

Subcellular Location:
Nucleus.

Tissue Specificity:
Widely expressed, notably in heart, kidney, placenta, prostate, skeletal muscle, testis and thymus, although the precise isoform varies according to tissue type. Progenitor cell layers of skin, breast, eye and prostate express high levels of DeltaN-type isoforms. Isoform 10 is predominantly expressed in skin squamous cell carcinomas, but not in normal skin tissues.

Post-translational modifications:
May be sumoylated.
Ubiquitinated. Polyubiquitination involves WWP1 and leads to proteasomal degradation of this protein.

DISEASE:
Defects in TP63 are the cause of acro-dermato-ungual-lacrimal-tooth syndrome (ADULT syndrome) [MIM:103285]; a form of ectodermal dysplasia. Ectodermal dysplasias (EDs) constitute a heterogeneous group of developmental disorders affecting tissues of ectodermal origin. EDs are characterized by abnormal development of two or more ectodermal structures such as hair, teeth, nails and sweat glands, with or without any additional clinical sign. Each combination of clinical features represents a different type of ectodermal dysplasia. ADULT syndrome involves ectrodactyly, syndactyly, finger- and toenail dysplasia, hypoplastic breasts and nipples, intensive freckling, lacrimal duct atresia, frontal alopecia, primary hypodontia, and loss of permanent teeth. ADULT differs significantly from EEC3 syndrome by the absence of facial clefting.

Similarity:
Belongs to the p53 family.
Contains 1 SAM (sterile alpha motif) domain.

SWISS:
Q9H3D4

Gene ID:
8626

Database links:

Entrez Gene: 8626 Human

Entrez Gene: 22061 Mouse

Entrez Gene: 246334 Rat

Omim: 603273 Human

SwissProt: Q9H3D4 Human

SwissProt: O88898 Mouse

SwissProt: Q9JJP6 Rat

Unigene: 137569 Human

Unigene: 20894 Mouse

Unigene: 42907 Rat



產品圖片
Paraformaldehyde-fixed, paraffin embedded (Human esophageal); Antigen retrieval by boiling in sodium citrate buffer (pH6.0) for 15min; Block endogenous peroxidase by 3% hydrogen peroxide for 20 minutes; Blocking buffer (normal goat serum) at 37°C for 30min; Antibody incubation with (P63) Monoclonal Antibody, Unconjugated (BH0150) overnight at 4°C, followed by operating according to SP Kit(Mouse)(sp-0024) instructionsand DAB staining.
Paraformaldehyde-fixed, paraffin embedded (human breast); Antigen retrieval by boiling in sodium citrate buffer (pH6.0) for 15min; Block endogenous peroxidase by 3% hydrogen peroxide for 20 minutes; Blocking buffer (normal goat serum) at 37°C for 30min; Antibody incubation with (P63) Monoclonal Antibody, Unconjugated (BH0150) overnight at 4°C, followed by operating according to SP Kit(Mouse)(sp-0024) instructionsand DAB staining.
版權所有 2004-2026 m.jywcc.com 北京博奧森生物技術有限公司
通過國際質量管理體系ISO 9001:2015 GB/T 19001-2016    證書編號: 00124Q34771R2M/1100
通過國際醫療器械-質量管理體系ISO 13485:2016 GB/T 42061-2022    證書編號: CQC24QY10047R0M/1100
京ICP備05066980號-1         京公網安備110107000727號
主站蜘蛛池模板: 久久69 | аⅴ天堂中文在线网官网 | 亚洲综合AV一区二区三区不卡 | 粗长巨龙挤进新婚少妇未删版 | 欧美国产激情18 | 黑人操女人视频 | 精品在线视频免费在线观看视频 | 人妻偷人VA精品国产旡码 | 97视频精品全国免费观看 | 看国产黄大片在线观看 | 国产一区二区三区精品在线观看 | 日韩欧美在线第一页 | 大陆一级黄色片 | 久久91精品国产91久久久 | A三级三级成人网站在线视频 | 性迷宫在线播放 | 韩日色图 | 国产二区交换配乱婬 | 粉嫩av一区二区三区在线观看 | 国产国产人免费视频成 | 国产亚洲精aa成人网站 | 久久久久久久久久爱 | 国产69精品久久久久人妻 | 高清国产亚洲精品自在久久 | 日本公与丰满熄理论在线播放 | 奶茶视频有容乃大海纳百川有容乃大绿巨人 | 被按摩的人妻中文字幕 | 无码少妇一区二区三区av | 免费国产黄色片 | 国产女人18毛片水真多 | 亚洲日韩看片无码AV | 亚洲视频综合在线 | 国内丰满少妇猛烈精品播 | 国产无人区二卡三卡四卡不见星空 | 亚洲日色| 国产第一福利影院 | 亚洲六十熟女系列 | 在线成人观看 | 丰满护士巨好爽好大乳小说 | 日韩影院久久 | 国产日韩精品一区在线观看播放 |