麻豆av资源_日本三级一区_www.狠狠艹_国产精妇在线观看第一区_成人性生交大片免费看中国A片_日本一本久久

掃碼關(guān)注公眾號(hào)           掃碼咨詢技術(shù)支持           掃碼咨詢技術(shù)服務(wù)
  
客服熱線:400-901-9800  客服QQ:4009019800  技術(shù)答疑  技術(shù)支持  質(zhì)量反饋  關(guān)于我們  聯(lián)系我們
诱人的女邻居9中文观看,性色av蜜臀av牛牛影院,男女后进式猛烈XX00免费视频
首頁(yè) > 產(chǎn)品中心 > 一抗 > 產(chǎn)品信息
Oct 4 (1F4) Mouse mAb (bsm-52001M)  
訂購(gòu)熱線:400-901-9800
訂購(gòu)郵箱:sales@bioss.com.cn
訂購(gòu)QQ:  400-901-9800
技術(shù)支持:techsupport@bioss.com.cn
50ul/1580.00元
100ul/2500.00元
大包裝/詢價(jià)
產(chǎn)品編號(hào) bsm-52001M
英文名稱 Oct 4 (1F4) Mouse mAb
中文名稱 胚胎干細(xì)胞關(guān)鍵蛋白單克隆抗體
別    名 MGC22487; Oct 3; Oct 4; Oct-3; Oct-4; OCT3; Oct4; Octamer binding protein 3; Octamer-binding protein 3; Octamer binding protein 4; Octamer binding transcription factor 3; Octamer-binding transcription factor 3; Octamer-4; POU domain transcription factor OCT4; OTF3; OTF4; OTF 3; OTF 4; OTF-3; POU class 5 homeobox 1; POU domain, class 5, transcription factor 1; POU domain class 5 transcription factor 1; PO5F1_HUMAN; POU type homeodomain containing DNA binding protein; POU5F1.  
研究領(lǐng)域 細(xì)胞生物  染色質(zhì)和核信號(hào)  信號(hào)轉(zhuǎn)導(dǎo)  干細(xì)胞  細(xì)胞周期蛋白  轉(zhuǎn)錄調(diào)節(jié)因子  細(xì)胞類型標(biāo)志物  表觀遺傳學(xué)  
抗體來(lái)源 Mouse
克隆類型 Monoclonal
克 隆 號(hào) 1F4
交叉反應(yīng) (predicted: Human)
產(chǎn)品應(yīng)用 WB=1:500-2000,ICC/IF=1:100-200
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
理論分子量 39 kDa
檢測(cè)分子量
細(xì)胞定位 細(xì)胞核 
性    狀 Liquid
濃    度 1mg/ml
免 疫 原 KLH conjugated synthetic peptide derived from human OCT4: 1-100/360 
亞    型 IgG
純化方法 affinity purified by Protein A
緩 沖 液 0.01M TBS (pH7.4) with 1% BSA, 0.02% Proclin300 and 50% Glycerol.
保存條件 Shipped at 4℃. Store at -20℃ for one year. Avoid repeated freeze/thaw cycles.
注意事項(xiàng) This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
PubMed PubMed
產(chǎn)品介紹 Expression of the POU-domain transcription factor Octamer-4 (Oct-4) is widely regarded as a hallmark of pluripotent stem cells. The relationship of Oct-4 to pluripotent stem cells is indicated by its tightly restricted expression to undifferentiated pluripotent stem cells. Upon differentiation to somatic lineages, the expression of Oct-4 disappears rapidly. Unlike the majority of pluripotent stem cell markers, the biological role of Oct-4 has been well characterized. Studies performed in mice point to the critical role of Oct-4 in the establishment and/or maintenance of pluripotent stem cells in an uncommitted state.

Function:
Transcription factor that binds to the octamer motif (5'-ATTTGCAT-3'). Forms a trimeric complex with SOX2 on DNA and controls the expression of a number of genes involved in embryonic development such as YES1, FGF4, UTF1 and ZFP206. Critical for early embryogenesis and for embryonic stem cell pluripotency.

Subunit:
Interacts with UBE2I and ZSCAN10. Interacts with PKM2. Interacts with WWP2.

Subcellular Location:
Nucleus.Note=Expressed in a diffuse and slightly punctuate pattern.

Tissue Specificity:
Expressed in developing brain. Highest levels found in specific cell layers of the cortex, the olfactory bulb, the hippocampus and the cerebellum. Low levels of expression in adult tissues.

Post-translational modifications:
Sumoylation enhances the protein stability, DNA binding and transactivation activity. Sumoylation is required for enhanced YES1 expression (By similarity).
Ubiquitinated; undergoes 'Lys-63'-linked polyubiquitination by WWP2 leading to proteasomal degradation (By similarity).
ERK1/2-mediated phosphorylation at Ser-111 promotes nuclear exclusion and proteasomal degradation. Phosphorylation at Thr-235 and Ser-236 decrease DNA-binding and alters ability to activate transcription.

Similarity:
Belongs to the POU transcription factor family. Class-5 subfamily.
Contains 1 homeobox DNA-binding domain.
Contains 1 POU-specific domain.

SWISS:
Q01860

Gene ID:
5460

Database links:

Entrez Gene: 282316 Cow

Entrez Gene: 5460 Human

Entrez Gene: 18999 Mouse

Entrez Gene: 100127461 Pig

Entrez Gene: 294562 Rat

Omim: 164177 Human

SwissProt: O97552 Cow

SwissProt: Q01860 Human

SwissProt: P20263 Mouse

SwissProt: Q9TSV5 Pig

Unigene: 249184 Human

Unigene: 632482 Human

Unigene: 646545 Human

Unigene: 17031 Mouse

Unigene: 161748 Rat



版權(quán)所有 2004-2026 m.jywcc.com 北京博奧森生物技術(shù)有限公司
通過(guò)國(guó)際質(zhì)量管理體系ISO 9001:2015 GB/T 19001-2016    證書(shū)編號(hào): 00124Q34771R2M/1100
通過(guò)國(guó)際醫(yī)療器械-質(zhì)量管理體系ISO 13485:2016 GB/T 42061-2022    證書(shū)編號(hào): CQC24QY10047R0M/1100
京ICP備05066980號(hào)-1         京公網(wǎng)安備110107000727號(hào)
主站蜘蛛池模板: 丰满人妻熟妇乱又伦精品软件 | 四虎影城 | 国产精品视频观看 | 99精品久久久 | 在线中文字幕精品第5页 | 欧美99视频 | 国产精品国语自产拍在线观看 | 久久精品2021国产 | 色网站免费看 | 久热草精品 | 99久精品视频 | 国产成一区二区 | 精精国产xxxx视频在线观看 | 成人免费视频www在线观看我 | 国产亚洲3P无码一区二区 | 国产1区 | 亚洲精品乱码久久久久久久久久 | av相关在线 | 小荡货好紧好爽 | av片免费在线播放 | 日日噜噜夜夜狠狠爱视频免费樱桃 | 精品1区2区3区4区产品乱码9 | 国产女教师高潮叫床视频网站 | 在线观看免费乇片 | 国语自产拍在线视频中文 | 日本亚洲一区二区三区 | 玖欧美性生交XXXXX无码 | 大胆裸体gogo毛片免费看 | 国产成人av在线播放 | 97国语精品自产拍在线观看 | 91色交| 麻豆成人精品视频 | 国产美女视频免费观看网址 | 日韩在线成人av | 欧美午夜片欧美片在线观看 | 一区二区三区四区五区在线 | 亚洲精品久久久久久久久久久 | yy6080午夜| 啊别插了视频高清在线观看 | 老师课后辅导乳揉搓H在线观看 | 男女作爱全部免费观爱 |