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Peroxiredoxin-5 Rabbit pAb (bs-22754R)  
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產品編號 bs-22754R
英文名稱 Peroxiredoxin-5 Rabbit pAb
中文名稱 過氧化還原酶5抗體
別    名 Alu corepressor 1; Antioxidant enzyme B166; AOEB166; Liver tissue 2D-page spot 71B; PLP; Peroxiredoxin V; Prx-V; Peroxisomal antioxidant enzyme; TPx type VI; Thioredoxin peroxidase PMP20; PRDX5; PRDX5_HUMAN  
研究領域 腫瘤  細胞生物  免疫學  細胞凋亡  線粒體  干擾素  
抗體來源 Rabbit
克隆類型 Polyclonal
克 隆 號
交叉反應 Rat (predicted: Human,Mouse,Pig,Cow,Dog,Horse)
產品應用 IHC-P=1:100-500,IHC-F=1:100-500,IF=1:100-500
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
理論分子量 22 kDa
檢測分子量
細胞定位 細胞漿 線粒體
性    狀 Liquid
濃    度 1mg/ml
免 疫 原 KLH conjugated synthetic peptide derived from human Peroxiredoxin-5: 51-150/214  
亞    型
純化方法 affinity purified by Protein A
緩 沖 液 0.01M TBS (pH7.4) with 1% BSA, 0.02% Proclin300 and 50% Glycerol.
保存條件 Shipped at 4℃. Store at -20℃ for one year. Avoid repeated freeze/thaw cycles.
注意事項 This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
PubMed PubMed
產品介紹 This gene encodes a member of the peroxiredoxin family of antioxidant enzymes, which reduce hydrogen peroxide and alkyl hydroperoxides. The encoded protein interacts with peroxisome receptor 1 and plays an antioxidant protective role in different tissues under normal conditions and during inflammatory processes. The use of alternate transcription start sites is thought to result in transcript variants that use different in-frame translational start codons to generate isoforms that are targeted to the mitochondrion (isoform L) or peroxisome/cytoplasm (isoform S). Multiple related pseudogenes have been defined for this gene. [provided by RefSeq, Nov 2017]

Function:
Thiol-specific peroxidase that catalyzes the reduction of hydrogen peroxide and organic hydroperoxides to water and alcohols, respectively. Plays a role in cell protection against oxidative stress by detoxifying peroxides and as sensor of hydrogen peroxide-mediated signaling events.

Subunit:
Monomer.

Subcellular Location:
Mitochondrion. Cytoplasm. Peroxisome.

Tissue Specificity:
Widely expressed.

Similarity:
Belongs to the peroxiredoxin 2 family.
Contains 1 thioredoxin domain.

SWISS:
P30044

Gene ID:
25824

Database links:

Entrez Gene: 25824 Human

Entrez Gene: 54683 Mouse

Entrez Gene: 113898 Rat

Omim: 606583 Human

SwissProt: P30044 Human

SwissProt: P99029 Mouse

SwissProt: Q9R063 Rat

Unigene: 502823 Human

Unigene: 279782 Mouse

Unigene: 2944 Rat




產品圖片
Paraformaldehyde-fixed, paraffin embedded (rat brain); Antigen retrieval by boiling in sodium citrate buffer (pH6.0) for 15min; Block endogenous peroxidase by 3% hydrogen peroxide for 20 minutes; Blocking buffer (normal goat serum) at 37°C for 30min; Antibody incubation with (Peroxiredoxin-5) Polyclonal Antibody, Unconjugated (bs-22754R) at 1:200 overnight at 4°C, followed by operating according to SP Kit(Rabbit) (sp-0023) instructionsand DAB staining.
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