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Human IL-5 ELISA Kit (bsk11005)  
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96T/2900.00元
大包裝/詢價
產品編號 bsk11005
英文名稱 Human IL-5 ELISA Kit
中文名稱 人白細胞介素5酶聯免疫試劑盒
別    名 IL5; EDF; IL-5; TRF; interleukin 5  
克 隆 號
種    屬 Human
線性范圍 1.60 - 100 pg/mL
應用范圍 S/P/CC
檢測限 1 pg/mL
適用樣品基質 cell culture supernates, serum, and plasma.
保存條件 Store at 4°C for 6 months, at -20°C for 12 months. Avoid multiple freeze-thaw cycles (Shipped with wet ice.).
注意事項 This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
產品介紹 Interleukin-5(IL-5)is a secreted glycoprotein that belongs to the α-helical group of cytokines. Unlike other family members, it is present as a covalently linked antiparallel dimer. The cDNA for human IL-5 encodes a signal peptide and a 115 amino acid (aa) mature protein. Mature human IL-5 shares 70%, 70%, 62%, 71%, 70% and 66%, aa sequence identity with mouse, rat, canine, equine, feline and porcine IL-5, respectively and shows cross-reactivity with mouse IL-5. IL-5 is primarily produced by CD4+ Th2 cells, but also by activated eosinophils, mast cells, EBV-transformed B cells, Reed-Sternberg cells in Hodgkin’s disease, and IL-2-stimulated invariant natural killer T cells (iNKT). IL-5 increases production and mobilization of eosinophils and CD34+ progenitors from the bone marrow and causes maturation of eosinophil precursors outside the bone marrow. The receptor for human IL-5, mainly expressed by eosinophils, but also found on basophils and mast cells, consists of a unique ligand-binding subunit (IL-5 Rα) and a shared Signaltransducing subunit, βc. IL-5 Rα first binds IL-5 at low affinity, then associates with preformed βc dimers, forming a high-affinity receptor. IL-5 also binds proteoglycans, potentially enhancing its activity. Soluble forms of IL-5 Rα antagonize IL-5 and can be found in vivo. In humans, IL-5 primarily affects cells of the eosinophilic lineage, and promotes their differentiation, maturation, activation, migration and survival, while in mice IL-5 also enhances Ig class switching and release from B1 cells. IL-5 also promotes differentiation of basophils and primes them for histamine and leukotriene release .

白介素 (IL) 5是一種主要在特應性疾病中起致病作用的細胞因子 ,又名B細胞分化因子 - μ、B細胞生長因子 2、T細胞替代因子、嗜酸粒細胞集落刺激因子 1、嗜酸粒細胞分化因子等。它調控著嗜酸粒細胞的產生、活化和分布 ,對B細胞、T細胞、嗜酸粒細胞、嗜堿粒細胞具有多種生物學功能。Azuma等于1986年克隆成功,是一種具有 白介素5多種生物學功能的淋巴因子。根據IL-5的作用,它被命名為T細胞替代因子(TRF)、B細胞生長因子Ⅱ(BCGFⅡ),嗜酸性粒細胞分化因子(EDF)和IgA增強因子。
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