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Human IL-1 R4/ST2 ELISA Kit (bsk11022)  
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96T/2900.00元
大包裝/詢價
產品編號 bsk11022
英文名稱 Human IL-1 R4/ST2 ELISA Kit
中文名稱 白細胞介素1受體4酶聯免疫試劑盒
Specific References  (1)     |     bsk11022 has been referenced in 1 publications.
[IF=1.918] Zefeng Wang. et al. Serum-Soluble ST2 Is a Novel Biomarker for Evaluating Left Atrial Low-Voltage Zone in Paroxysmal Atrial Fibrillation. Med Sci Monitor. 2020; 26: e926221-1–e926221-9  ELISA ;  Human.  
克 隆 號
種    屬 Human
線性范圍 31.20 - 2,000 pg/mL
應用范圍 S/P/CC
檢測限 15 pg/mL
適用樣品基質 cell culture supernates, serum, and plasma.
保存條件 Store at 4°C for 6 months, at -20°C for 12 months. Avoid multiple freeze-thaw cycles (Shipped with wet ice.).
注意事項 This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
產品介紹 The interleukin-1 receptor antagonist (IL-1RA) is a protein that in humans is encoded by the IL1RN gene.IL-1RA was initially called the IL-1 inhibitor and was discovered separately in 1984 by two independent laboratories.IL-1RA is an agent that binds non-productively to the cell surface interleukin-1 receptor (IL-1R), the same receptor that binds interleukin 1 (IL-1), preventing IL-1 from sending a signal to that cell.A polymorphism of this gene is reported to be associated with increased risk of osteoporotic fractures and gastric cancer. Mutations in the IL1RN gene results in a rare disease called deficiency of the interleukin-1–receptor antagonist (DIRA).Variants of the IL1RN gene is also associated with risk of schizophrenia.Elevated levels of IL1RN has been found in serum of schizophrenia patients.An interleukin 1 receptor antagonist is used in the treatment of rheumatoid arthritis, an autoimmune disease in which IL-1 plays a key role. It is commercially produced as anakinra, which is a human recombinant form of IL-1RA. In terms of protein similarities, IL-1β is more closely related to IL-1RA than it is to IL- 1α. The amino acids that are identical between mature human IL-1α and mature IL-1β is 22% while it is 26% when comparing IL-1β to IL-1RA and only 18% when comparing IL-1α to IL-1RA.

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