麻豆av资源_日本三级一区_www.狠狠艹_国产精妇在线观看第一区_成人性生交大片免费看中国A片_日本一本久久

掃碼關注公眾號           掃碼咨詢技術支持           掃碼咨詢技術服務
  
客服熱線:400-901-9800  客服QQ:4009019800  技術答疑  技術支持  質量反饋  關于我們  聯系我們
人妻丝袜AV中文系列先锋影音,2019理论片一级,亚洲精品亚洲人成在线观看麻豆
首頁 > 產品中心 > 一抗 > 產品信息
Huntingtin Recombinant Rabbit mAb (bsm-54305R)  
訂購熱線:400-901-9800
訂購郵箱:sales@bioss.com.cn
訂購QQ:  400-901-9800
技術支持:techsupport@bioss.com.cn
50ul/1400.00元
100ul/2500.00元
大包裝/詢價

產品編號 bsm-54305R
英文名稱 Huntingtin Recombinant Rabbit mAb
中文名稱 神經性舞蹈病蛋白重組兔單抗
別    名 HD; HD protein; HD_HUMAN; HDH; HTT; Huntingtin; HUNTINGTON CHOREA; Huntington disease protein; Huntington's disease protein homolog; IT 15; IT15; OTTMUSP00000026909; ZHD; AI256365; C430023I11Rik.  
研究領域 細胞生物  神經生物學  Alzheimer's  
抗體來源 Rabbit
克隆類型 Recombinant
克 隆 號 1F10
交叉反應 Human,Mouse,Rat
產品應用 WB=1:500-2000,IHC-P=1:50-200,IHC-F=1:50-200,IF=1:50-200,ICC/IF=1:50-200
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
理論分子量 347 kDa
檢測分子量
細胞定位 細胞核 細胞漿 
性    狀 Liquid
濃    度 1mg/ml
免 疫 原 A synthesized peptide derived from human Huntingtin: 1-47 
亞    型 IgG
純化方法 affinity purified by Protein A
緩 沖 液 0.01M TBS (pH7.4) with 1% BSA, 0.02% Proclin300 and 50% Glycerol.
保存條件 Shipped at 4℃. Store at -20℃ for one year. Avoid repeated freeze/thaw cycles.
注意事項 This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
PubMed PubMed
產品介紹 Huntingtin is a protein that contains a polyglutamine region. When the number of glutamine repeats exceeds 35, the gene encodes a version of Huntingtin that leads to Huntington’s disease (HD). When the polyglutamine stretch is mutated, Huntingtin acts within the nucleus to induce neurodegeneration by a cell-specific apoptotic mechanism. Loss of Huntingtin activity is unlikely to be the cause of HD, and it has been proposed that the expanded glutamine repeat region may induce an abnormal interaction between the mutant protein and other cellular proteins. Huntingtin interacts with a variety of proteins including HAP1, glyceraldehyde phosphate dehydrogenase (GAPDH) and HIP1.

Function:
May play a role in microtubule-mediated transport or vesicle function.

Subunit:
Binds SH3GLB1 (By similarity). Interacts through its N-terminus with PRPF40A. Interacts with PQBP1, SETD2 and SYVN. Interacts with PFN1.

Subcellular Location:
Cytoplasm. Nucleus. The mutant Huntingtin protein colocalizes with AKAP8L in the nuclear matrix of Huntington's disease neurons.

Tissue Specificity:
Expressed in the brain cortex (at protein level). Widely expressed with the highest level of expression in the brain (nerve fibers, varicosities, and nerve endings). In the brain, the regions where it can be mainly found are the cerebellar cortex, the neocortex, the striatum, and the hippocampal formation.

Post-translational modifications:
Cleaved by apopain downstream of the polyglutamine stretch. The resulting N-terminal fragment is cytotoxic and provokes apoptosis.
Forms with expanded polyglutamine expansion are specifically ubiquitinated by SYVN1, which promotes their proteasomal degradation.

DISEASE:
Defects in HTT are the cause of Huntington disease (HD) [MIM:143100]. HD is an autosomal dominant neurodegenerative disorder characterized by involuntary movements (chorea), general motor impairment, psychiatric disorders and dementia. Onset of the disease occurs usually in the third or fourth decade of life and symptoms progressively worsen leading to death in 10 to 20 years. Onset and clinical course depend on the degree of poly-Gln repeat expansion, longer expansions resulting in earlier onset and more severe clinical manifestations. HD affects 1 in 10,000 individuals of European origin. Neuropathology of Huntington disease displays a distinctive pattern with loss of neurons, especially in the caudate and putamen (striatum).

Similarity:
Belongs to the huntingtin family.
Contains 10 HEAT repeats.

SWISS:
P42858

Gene ID:
3064

Database links:

Entrez Gene: 3064 Human

Entrez Gene: 15194 Mouse

Entrez Gene: 29424 Rat

Omim: 143100 Human

Omim: 613004 Human

SwissProt: P42858 Human

SwissProt: P42859 Mouse

SwissProt: P51111 Rat

Unigene: 518450 Human

Unigene: 209071 Mouse

Unigene: 482929 Mouse

Unigene: 11193 Rat



產品圖片
25 ug total protein per lane of various lysates (see on figure) probed with Huntingtin monoclonal antibody, unconjugated (bsm-54305R) at 1:2000 dilution and 4°C overnight incubation. Followed by conjugated secondary antibody incubation at r.t. for 60 min.
Paraformaldehyde-fixed, paraffin embedded Human Cerebellum; Antigen retrieval by boiling in sodium citrate buffer (pH6.0) for 15 min; Antibody incubation with Huntingtin Monoclonal Antibody, Unconjugated(bsm-54305R) at 1:200 overnight at 4°C, followed by conjugation to the bs-0295G-HRP and DAB (C-0010) staining.
Paraformaldehyde-fixed, paraffin embedded Rat Cerebellum; Antigen retrieval by boiling in sodium citrate buffer (pH6.0) for 15 min; Antibody incubation with Huntingtin Monoclonal Antibody, Unconjugated(bsm-54305R) at 1:200 overnight at 4°C, followed by conjugation to the bs-0295G-HRP and DAB (C-0010) staining.
Paraformaldehyde-fixed, paraffin embedded Human Testicles; Antigen retrieval by boiling in sodium citrate buffer (pH6.0) for 15 min; Antibody incubation with Huntingtin Monoclonal Antibody, Unconjugated(bsm-54305R) at 1:200 overnight at 4°C, followed by conjugation to the bs-0295G-HRP and DAB (C-0010) staining.
Paraformaldehyde-fixed, paraffin embedded Rat Testicles; Antigen retrieval by boiling in sodium citrate buffer (pH6.0) for 15 min; Antibody incubation with Huntingtin Monoclonal Antibody, Unconjugated(bsm-54305R) at 1:200 overnight at 4°C, followed by conjugation to the bs-0295G-HRP and DAB (C-0010) staining.
Paraformaldehyde-fixed, paraffin embedded Human Cerebrum; Antigen retrieval by boiling in sodium citrate buffer (pH6.0) for 15 min; Antibody incubation with Huntingtin Monoclonal Antibody, Unconjugated(bsm-54305R) at 1:200 overnight at 4°C, followed by conjugation to the bs-0295G-HRP and DAB (C-0010) staining.
Paraformaldehyde-fixed, paraffin embedded Rat Cerebrum; Antigen retrieval by boiling in sodium citrate buffer (pH6.0) for 15 min; Antibody incubation with Huntingtin Monoclonal Antibody, Unconjugated(bsm-54305R) at 1:200 overnight at 4°C, followed by conjugation to the bs-0295G-HRP and DAB (C-0010) staining.
Paraformaldehyde-fixed, paraffin embedded Mouse Cerebrum; Antigen retrieval by boiling in sodium citrate buffer (pH6.0) for 15 min; Antibody incubation with Huntingtin Monoclonal Antibody, Unconjugated(bsm-54305R) at 1:200 overnight at 4°C, followed by conjugation to the bs-0295G-HRP and DAB (C-0010) staining.
版權所有 2004-2026 m.jywcc.com 北京博奧森生物技術有限公司
通過國際質量管理體系ISO 9001:2015 GB/T 19001-2016    證書編號: 00124Q34771R2M/1100
通過國際醫療器械-質量管理體系ISO 13485:2016 GB/T 42061-2022    證書編號: CQC24QY10047R0M/1100
京ICP備05066980號-1         京公網安備110107000727號
主站蜘蛛池模板: 啊灬啊灬啊灬快灬深高潮了 | 婷婷去俺也去 | 国产成人乱色视频网站 | 欧美精品无码久久久潘金莲 | 狠狠色狠狠爱综合蜜芽五月 | 日韩精品在线观看一区二区 | 一级av黄色毛片 | 一区二区三区免费av | 国产精品7777777 | 一起艹在线观看 | 中文字幕制服 | 欧美成年黄网站色视频 | 亚洲乱码国产乱码精品精小说 | 性高湖久久久久久久久免费 | 久久久久亚洲最大xxxx | 国产亚洲精品线观看动态图 | 免费a网站 | 一区二区三区国产亚洲网站 | 成人午夜视频在线播放 | 国产精品高潮久久久久无 | 欧美午夜一区二区福利视频 | 欧美日韩图区 | 苍井空毛片精品久久久 | 91精品无码专区一区二区 | 欧美wwwwxxxx | 91久久精品夜夜躁日日躁欧美 | 国产特级毛片AAAAAA高潮流水 | 在线黑人抽搐潮喷 | 涩涩涩av | 懂色av中文字幕一区二区三区 | 亚洲va无码va在线va天堂 | 拍真实国产伦偷精品 | 狠狠躁18三区二区一区 | 免费可以在线看A∨网站 | 国产91av视频在线观看 | 国内精品久久久久久久影院 | 老师夹震蛋上课出白浆 | 羞羞国产一区二区三区四区 | 啊灬啊灬啊灬快灬A片免费 精品久久一 | 国产一区二区免费在线播放 | 精品人妻系列无码人妻免费视频 |