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RNF43 Rabbit pAb (bs-24331R)  
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產品編號 bs-24331R
英文名稱 RNF43 Rabbit pAb
中文名稱 環指蛋白43抗體
別    名 RNF124; Ring finger protein 43; URCC; RNF43_HUMAN; E3 ubiquitin-protein ligase RNF43; RING finger protein 43.  
Specific References  (1)     |     bs-24331R has been referenced in 1 publications.
[IF=7.109] Ding, Meng. et al. Cancer-associated fibroblasts promote the stemness and progression of renal cell carcinoma via exosomal miR-181d-5p. CELL DEATH DISCOV. 2022 Nov;8(1):1-15  WB, IHC ;  Human.  
研究領域 腫瘤  細胞生物  腫瘤細胞生物標志物  
抗體來源 Rabbit
克隆類型 Polyclonal
克 隆 號
交叉反應 Human,Mouse,Rat (predicted: Pig,Cow,Dog,Horse)
產品應用 WB=1:500-2000
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
理論分子量 83 kDa
檢測分子量
細胞定位 細胞核 細胞漿 細胞膜 
性    狀 Liquid
濃    度 1mg/ml
免 疫 原 KLH conjugated synthetic peptide derived from human RNF43: 401-500/783 <Extracellular>
亞    型 IgG
純化方法 affinity purified by Protein A
緩 沖 液 0.01M TBS (pH7.4) with 1% BSA, 0.02% Proclin300 and 50% Glycerol.
保存條件 Shipped at 4℃. Store at -20℃ for one year. Avoid repeated freeze/thaw cycles.
注意事項 This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
PubMed PubMed
產品介紹 RNF43 is a probable E3 ubiquitin-protein ligase that promotes cell growth and is upregulated in colon cancer. E3 ubiquitin ligases accept ubiquitin from an E2 ubiquitin-conjugating enzyme in the form of a thioester and then directly transfer the ubiquitin to targeted substrates.

Function:
Probable E3 ubiquitin-protein ligase. E3 ubiquitin ligases accept ubiquitin from an E2 ubiquitin-conjugating enzyme in the form of a thioester and then directly transfer the ubiquitin to targeted substrates.

Subunit:
Interacts with AKAP8L, NONO and SFPQ.

Subcellular Location:
Endoplasmic reticulum membrane; Single-pass type I membrane protein (Potential). Nucleus envelope.

Tissue Specificity:
Expressed in fetal kidney, fetal lung, in colon cancer tissues, hepatocellular carcinomas and lung adenocarcinomas. Overexpressed in colorectal cancer cell lines.

Similarity:
Contains 1 RING-type zinc finger.

SWISS:
Q68DV7

Gene ID:
54894

Database links:

Entrez Gene: 54894 Human

Entrez Gene: 207742 Mouse

Entrez Gene: 303412 Rat

Omim: 612482 Human

SwissProt: Q68DV7 Human

SwissProt: Q5NCP0 Mouse

Unigene: 584916 Human

Unigene: 440230 Mouse

Unigene: 214174 Rat



產品圖片
Sample: Lane 1: Mouse Cerebrum tissue lysates Lane 2: Mouse Pancreas tissue lysates Lane 3: Mouse Lung tissue lysates Lane 4: Mouse Heart tissue lysates Lane 5: Human 293T cell lysates Lane 6: Human HepG2 cell lysates Lane 7: Human A549 cell lysates Lane 8: Human HL-60 cell lysates Primary: Anti-RNF43 (bs-24331R) at 1/1000 dilution Secondary: IRDye800CW Goat Anti-Rabbit IgG at 1/20000 dilution Predicted band size: 83 kDa Observed band size: 110 kDa
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