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ADRB2 Recombinant Rabbit mAb (bsm-52880R)  
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產品編號 bsm-52880R
英文名稱 ADRB2 Recombinant Rabbit mAb
中文名稱 腎上腺素能受體β2重組兔單抗
別    名 beta 2-adrenergic receptor; beta 2 Adrenergic Receptor; ADRB2R; ADRBR; ADRB2_HUMAN; Adrenergic beta 2 receptor surface; B2AR; BAR; beta 2 adrenoreceptor; BETA2AR; Catecholamine receptor; beta2-adrenergic receptor.  
研究領域 腫瘤  細胞生物  神經生物學  細胞膜受體  
抗體來源 Rabbit
克隆類型 Recombinant
克 隆 號 7C1
交叉反應 Human,Mouse,Rat
產品應用 IHC-P=1:50-200,IHC-F=1:50-200,IF=1:50-200
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
理論分子量 60 kDa
檢測分子量
性    狀 Liquid
濃    度 1mg/ml
免 疫 原 A synthesized peptide derived from human beta 2 Adrenergic receptor: 360-413/413 
亞    型 IgG
純化方法 affinity purified by Protein A
緩 沖 液 0.01M TBS (pH7.4) with 1% BSA, 0.02% Proclin300 and 50% Glycerol.
保存條件 Shipped at 4℃. Store at -20℃ for one year. Avoid repeated freeze/thaw cycles.
注意事項 This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
PubMed PubMed
產品介紹 Beta 2 Adrenergic Receptor is a member of the G protein coupled receptor superfamily. This receptor is directly associated with one of its ultimate effectors, the class C L type calcium channel Ca(V)1.2. This receptor channel complex also contains a G protein, an adenylyl cyclase, cAMP dependent kinase, and the counterbalancing phosphatase, PP2A. The assembly of the signaling complex provides a mechanism that ensures specific and rapid signaling by this G protein coupled receptor. This gene contains no introns in either its coding or untranslated sequences. Different polymorphic forms, point mutations, and/or downregulation of this gene are associated with nocturnal asthma, obesity and type 2 diabetes. Expression of the beta 2 Adrenergic Receptor has been reported in adipose, blood, brain, heart, lung, nose, pancreas, skeletal muscle, skin, and vessel.

Function:
Beta-adrenergic receptors mediate the catecholamine-induced activation of adenylate cyclase through the action of G proteins. The beta-2-adrenergic receptor binds epinephrine with an approximately 30-fold greater affinity than it does norepinephrine.

Subunit:
Binds SLC9A3R1 and GPRASP1. Interacts with ARRB1 and ARRB2. Interacts with SRC, USP20 and USP33. Interacts with VHL; the interaction, which is increased on hydroxylation of ADRB2, ubiquitinates ADRB2 leading to its degradation. Interacts with EGLN3; the interaction hydroxylates ADRB2 facilitating VHL-E3 ligase-mediated ubiquitination.

Subcellular Location:
Cell membrane; Multi-pass membrane protein. Note=Colocalizes with VHL at the cell membrane.

Similarity:
Belongs to the G-protein coupled receptor 1 family.
Adrenergic receptor subfamily. ADRB2 sub-subfamily.

SWISS:
P07550

Gene ID:
154

產品圖片
Paraformaldehyde-fixed, paraffin embedded Rat Heart; Antigen retrieval by boiling in sodium citrate buffer (pH6.0) for 15 min; Antibody incubation with ADRB2 Monoclonal Antibody, Unconjugated (bsm-52880R) at 1:200 overnight at 4°C, followed by conjugation to the bs-0295G-HRP and DAB (C-0010) staining.
Paraformaldehyde-fixed, paraffin embedded Human Cerebrum; Antigen retrieval by boiling in sodium citrate buffer (pH6.0) for 15 min; Antibody incubation with ADRB2 Monoclonal Antibody, Unconjugated (bsm-52880R) at 1:200 overnight at 4°C, followed by conjugation to the bs-0295G-HRP and DAB (C-0010) staining.
Paraformaldehyde-fixed, paraffin embedded Rat Cerebrum; Antigen retrieval by boiling in sodium citrate buffer (pH6.0) for 15 min; Antibody incubation with ADRB2 Monoclonal Antibody, Unconjugated (bsm-52880R) at 1:200 overnight at 4°C, followed by conjugation to the bs-0295G-HRP and DAB (C-0010) staining.
Paraformaldehyde-fixed, paraffin embedded Mouse Cerebrum; Antigen retrieval by boiling in sodium citrate buffer (pH6.0) for 15 min; Antibody incubation with ADRB2 Monoclonal Antibody, Unconjugated (bsm-52880R) at 1:200 overnight at 4°C, followed by conjugation to the bs-0295G-HRP and DAB (C-0010) staining.
Paraformaldehyde-fixed, paraffin embedded Rat Colon; Antigen retrieval by boiling in sodium citrate buffer (pH6.0) for 15 min; Antibody incubation with ADRB2 Monoclonal Antibody, Unconjugated (bsm-52880R) at 1:200 overnight at 4°C, followed by conjugation to the bs-0295G-HRP and DAB (C-0010) staining.
Paraformaldehyde-fixed, paraffin embedded Mouse Colon; Antigen retrieval by boiling in sodium citrate buffer (pH6.0) for 15 min; Antibody incubation with ADRB2 Monoclonal Antibody, Unconjugated (bsm-52880R) at 1:200 overnight at 4°C, followed by conjugation to the bs-0295G-HRP and DAB (C-0010) staining.
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