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CD38 Mouse mAb (bsm-34151M)  
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50ul/1180.00元
100ul/1980.00元
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產(chǎn)品編號(hào) bsm-34151M
英文名稱 CD38 Mouse mAb
中文名稱 CD38單克隆抗體
別    名 ADP-ribosyl cyclase/cyclic ADP-ribose hydrolase 1; 2'-phospho-ADP-ribosyl cyclase; 2'-phospho-ADP-ribosyl cyclase/2'-phospho-cyclic-ADP-ribose transferase; 2'-phospho-cyclic-ADP-ribose transferase; ADP-ribosyl cyclase 1; ADPRC 1; Cyclic ADP-ribose hydrolase 1; cADPr hydrolase 1; T10; CD38_HUMAN; CD38_MOUSE; I-19; NIM-R5 antigen.  
抗體來(lái)源 Mouse
克隆類型 Monoclonal
克 隆 號(hào) 1C9
交叉反應(yīng) Human
產(chǎn)品應(yīng)用 IHC-P=1:100-500,IHC-F=1:100-500,IF=1:100-500
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
理論分子量 34 kDa
檢測(cè)分子量
細(xì)胞定位 細(xì)胞膜 
性    狀 Liquid
濃    度 1mg/ml
免 疫 原 KLH conjugated synthetic peptide derived from human CD38 
亞    型 IgG1, Kappa
純化方法 affinity purified by Protein A
緩 沖 液 Liquid in PBS containing, 0.5% BSA and 0.02% Proclin300.
保存條件 Shipped at 4℃. Store at -20℃ for one year. Avoid repeated freeze/thaw cycles.
注意事項(xiàng) This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
PubMed PubMed
產(chǎn)品介紹 The protein encoded by this gene is a non-lineage-restricted, type II transmembrane glycoprotein that synthesizes and hydrolyzes cyclic adenosine 5'-diphosphate-ribose, an intracellular calcium ion mobilizing messenger. The release of soluble protein and the ability of membrane-bound protein to become internalized indicate both extracellular and intracellular functions for the protein. This protein has an N-terminal cytoplasmic tail, a single membrane-spanning domain, and a C-terminal extracellular region with four N-glycosylation sites. Crystal structure analysis demonstrates that the functional molecule is a dimer, with the central portion containing the catalytic site. It is used as a prognostic marker for patients with chronic lymphocytic leukemia. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Sep 2015]

Function:
Synthesizes cyclic ADP-ribose, a second messenger for glucose-induced insulin secretion. Also has cADPr hydrolase activity. Also moonlights as a receptor in cells of the immune system.

Subcellular Location:
Membrane; Single-pass type II membrane protein.

Tissue Specificity:
Expressed at high levels in pancreas, liver, kidney, brain, testis, ovary, placenta, malignant lymphoma and neuroblastoma.

Similarity:
Belongs to the ADP-ribosyl cyclase family.

SWISS:
P28907

Gene ID:
952

Database links:

Entrez Gene: 952 Human

Omim: 107270 Human

SwissProt: P28907 Human

Unigene: 479214 Human



CD38分子是單鏈Ⅱ型跨膜糖蛋白,存在于很多免疫細(xì)胞表面上,CD38與無(wú)脊椎動(dòng)物卵的授精、HIV感染、某些癌癥以及糖尿病等有關(guān),CD38具有許多復(fù)雜而又獨(dú)特的生物學(xué)特性及功能,有調(diào)控細(xì)胞鈣釋放的機(jī)制。主要表達(dá)于胸腺細(xì)胞、前T和前B細(xì)胞、活化的T和B細(xì)胞、單核細(xì)胞、NK細(xì)胞、漿細(xì)胞等,可用于急性白血病的分型和活化的T細(xì)胞在自身免疫和免疫缺陷中的作用等方面的研究,也可作為生發(fā)中心B細(xì)胞的一種選擇性標(biāo)記。
產(chǎn)品圖片
Paraformaldehyde-fixed, paraffin embedded (human lung carcinoma); Antigen retrieval by boiling in sodium citrate buffer (pH6.0) for 15min; Block endogenous peroxidase by 3% hydrogen peroxide for 20 minutes; Blocking buffer (normal goat serum) at 37°C for 30min; Incubation with (CD38) Monoclonal Antibody, Unconjugated (bsm-34151M) at 1:200 overnight at 4°C, followed by operating according to SP Kit(Mouse)(sp-0024) instructionsand DAB staining.
Paraformaldehyde-fixed, paraffin embedded (human kidney carcinoma ); Antigen retrieval by boiling in sodium citrate buffer (pH6.0) for 15min; Block endogenous peroxidase by 3% hydrogen peroxide for 20 minutes; Blocking buffer (normal goat serum) at 37°C for 30min; Incubation with (CD38) Monoclonal Antibody, Unconjugated (bsm-34151M) at 1:200 overnight at 4°C, followed by operating according to SP Kit(Mouse)(sp-0024) instructionsand DAB staining.
Paraformaldehyde-fixed, paraffin embedded (human colon ); Antigen retrieval by boiling in sodium citrate buffer (pH6.0) for 15min; Block endogenous peroxidase by 3% hydrogen peroxide for 20 minutes; Blocking buffer (normal goat serum) at 37°C for 30min; Incubation with (CD38) Monoclonal Antibody, Unconjugated (bsm-34151M) at 1:200 overnight at 4°C, followed by operating according to SP Kit(Mouse)(sp-0024) instructionsand DAB staining.
Paraformaldehyde-fixed, paraffin embedded (human tonsil); Antigen retrieval by boiling in sodium citrate buffer (pH6.0) for 15min; Block endogenous peroxidase by 3% hydrogen peroxide for 20 minutes; Blocking buffer (normal goat serum) at 37°C for 30min; Incubation with (CD38) Monoclonal Antibody, Unconjugated (bsm-34151M) at 1:200 overnight at 4°C, followed by operating according to SP Kit(Mouse)(sp-0024) instructionsand DAB staining.
Paraformaldehyde-fixed, paraffin embedded (human colon carcinoma); Antigen retrieval by boiling in sodium citrate buffer (pH6.0) for 15min; Block endogenous peroxidase by 3% hydrogen peroxide for 20 minutes; Blocking buffer (normal goat serum) at 37°C for 30min; Incubation with (CD38) Monoclonal Antibody, Unconjugated (bsm-34151M) at 1:200 overnight at 4°C, followed by operating according to SP Kit(Mouse)(sp-0024) instructionsand DAB staining.
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