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[KO驗證抗體] lamin B1 Rabbit pAb (bs-55118R)  
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產品編號 bs-55118R
英文名稱 [KO驗證抗體] lamin B1 Rabbit pAb
中文名稱 核纖層蛋白B抗體(細胞核膜標志物)
別    名 LMNB1_HUMAN; Lamin-B1; LMNB1; LMN2; LMNB; LMN; ADLD; MCPH26;  
研究領域 細胞生物  染色質和核信號  信號轉導  細胞凋亡  細胞類型標志物  
抗體來源 Rabbit
克隆類型 Polyclonal
克 隆 號
交叉反應 Human,Mouse,Rat
產品應用 WB=1:500-2000,IHC-P=1:100-500,IHC-F=1:100-500,IF=1:100-500,ICC/IF=1:50-200
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
理論分子量 66 kDa
檢測分子量
細胞定位 細胞核 
性    狀 Liquid
濃    度 1mg/ml
免 疫 原 Recombinant human Lamin B1: 397-586/586 
亞    型 IgG
純化方法 affinity purified by Protein A
緩 沖 液 0.01M TBS (pH7.4) with 1% BSA, 0.02% Proclin300 and 50% Glycerol.
保存條件 Store at -20℃ for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antib
注意事項 This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
PubMed PubMed
產品介紹 The nuclear lamina consists of a two-dimensional matrix of proteins located next to the inner nuclear membrane. The lamin family of proteins make up the matrix and are highly conserved in evolution. During mitosis, the lamina matrix is reversibly disassembled as the lamin proteins are phosphorylated. Lamin proteins are thought to be involved in nuclear stability, chromatin structure and gene expression. Vertebrate lamins consist of two types, A and B. This gene encodes one of the two B type proteins, B1. Alternative splicing results in transcript variants and a duplication of this gene is associated with autosomal dominant adult-onset leukodystrophy (ADLD). [provided by RefSeq, Oct 2010].

Function:
Lamins are components of the nuclear lamina, a fibrous layer on the nucleoplasmic side of the inner nuclear membrane, which is thought to provide a framework for the nuclear envelope and may also interact with chromatin.

Subunit:
Homodimer. Interacts with lamin-associated polypeptides IA, IB and 2.

Subcellular Location:
Nucleus inner membrane; Lipid-anchor; Nucleoplasmic side.

Post-translational modifications:
B-type lamins undergo a series of modifications, such as farnesylation and phosphorylation. Increased phosphorylation of the lamins occurs before envelope disintegration and probably plays a role in regulating lamin associations.

DISEASE:
Defects in LMNB1 are the cause of leukodystrophy demyelinating autosomal dominant adult-onset (ADLD) [MIM:169500]. ADLD is a slowly progressive and fatal demyelinating leukodystrophy, presenting in the fourth or fifth decade of life. Clinically characterized by early autonomic abnormalities, pyramidal and cerebellar dysfunction, and symmetric demyelination of the CNS. It differs from multiple sclerosis and other demyelinating disorders in that neuropathology shows preservation of oligodendroglia in the presence of subtotal demyelination and lack of astrogliosis.

Similarity:
Belongs to the intermediate filament family.

SWISS:
P20700

Gene ID:
4001

Database links:

Entrez Gene: 396223 Chicken

Entrez Gene: 4001 Human

Entrez Gene: 16906 Mouse

Entrez Gene: 116685 Rat

Omim: 150340 Human

SwissProt: P14731 Chicken

SwissProt: P20700 Human

SwissProt: P14733 Mouse

SwissProt: P70615 Rat

Unigene: 89497 Human

Unigene: 4105 Mouse

Unigene: 11362 Rat



核膜標志物(Nuclear Envelope Marker) 核纖層蛋白(Lamin) 是緊貼核內膜的一層厚度為20~50nm的纖維蛋白層或纖維網絡。核纖層與細胞質骨架、核骨架連成一個整體,一般認為核纖層將核被膜和染色質提供了結構支架。有學者研究認為:lamin蛋白與細胞凋亡及衰老有關聯,它包括:核纖層蛋白A、核纖層蛋白B、核纖層蛋白C幾個不同亞型的蛋白。
產品圖片
Sample: Lane 1: Cerebrum (Mouse) Lysate at 40 ug Lane 2: Pancreas (Mouse) Lysate at 40 ug Lane 3: Testis (Mouse) Lysate at 40 ug Lane 4: Stomach (Mouse) Lysate at 40 ug Lane 5: Cerebrum (Rat) Lysate at 40 ug Lane 7: Testis (Rat) Lysate at 40 ug Lane 8: Stomach (Rat) Lysate at 40 ug Lane 9: U937 (Human) Cell Lysate at 30 ug Lane 10: Jurkat (Human) Cell Lysate at 30 ug Lane 11: Molt-4 (Human) Cell Lysate at 30 ug Lane 12: THP-1 (Human) Cell Lysate at 30 ug Lane 13: Hela (Human) Cell Lysate at 30 ug Primary: Anti- Lamin B1 (bs-55118R) at 1/1000 dilution Anti-beta-Actin (bs-0061R) at 1/2000 dilution Secondary: IRDye800CW Goat Anti-Rabbit IgG at 1/20000 dilution Predicted band size: 67-70 kD Observed band size: 65 kD
Paraformaldehyde-fixed, paraffin embedded (human breast); Antigen retrieval by boiling in sodium citrate buffer (pH6.0) for 15min; Block endogenous peroxidase by 3% hydrogen peroxide for 20 minutes; Blocking buffer (normal goat serum) at 37°C for 30min; Antibody incubation with (Lamin B1) Polyclonal Antibody, Unconjugated (bs-55118R) at 1:100 overnight at 4°C, followed by operating according to SP Kit(Rabbit) (sp-0023) instructionsand DAB staining.
Paraformaldehyde-fixed, paraffin embedded (mouse brain); Antigen retrieval by boiling in sodium citrate buffer (pH6.0) for 15min; Block endogenous peroxidase by 3% hydrogen peroxide for 20 minutes; Blocking buffer (normal goat serum) at 37°C for 30min; Antibody incubation with (Lamin B1) Polyclonal Antibody, Unconjugated (bs-55118R) at 1:100 overnight at 4°C, followed by operating according to SP Kit(Rabbit) (sp-0023) instructionsand DAB staining.
Paraformaldehyde-fixed, paraffin embedded (rat brain); Antigen retrieval by boiling in sodium citrate buffer (pH6.0) for 15min; Block endogenous peroxidase by 3% hydrogen peroxide for 20 minutes; Blocking buffer (normal goat serum) at 37°C for 30min; Antibody incubation with (Lamin B1) Polyclonal Antibody, Unconjugated (bs-55118R) at 1:100 overnight at 4°C, followed by operating according to SP Kit(Rabbit) (sp-0023) instructionsand DAB staining.
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