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Anti-LAG-3 & PD-1 Reference Antibody (Tebotelimab Biosimilar) (BIO1000SM)  
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100ug/詢價
1mg/詢價
5mg/詢價
大包裝/詢價

產品編號 BIO1000SM
英文名稱 Anti-LAG-3 & PD-1 Reference Antibody (Tebotelimab Biosimilar)
別    名 LAG3 / CD223 & PDCD1 / PD-1 / CD279; Tebotelimab  
抗體來源
克隆類型 Monoclonal
交叉反應 Human
產品應用
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
理論分子量 165.68kDa
性    狀 Lyophilized
亞    型 DART-DART-Fc
純化方法 Protein A
緩 沖 液 100 mM Pro-Ac 20mM Arg pH 5.0
保存條件 -80°C for 2 years under sterile conditions; -20°C for 1 year under sterile conditions;Avoid repeated freeze-thaw cycles.
注意事項 This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
PubMed PubMed
產品介紹
產品圖片
Co-incubation of Tebotelimab with PD-1-NF-AT-Jurkat and CD3L-huPD-L1-CHO-K cells and incubated for 6 hours. Bright-Lite was used to detect the fluorescent signal. As shown in fig, Tebotelimab was able to block the PD-1/PD-L1 signaling pathway, and the EC50 was 1.266 nM.
Tebotelimab bound to huPD-1-Jurkat cells, and then rebounded to fluorescent secondary antibodies(Anti-Human IgG, Fcγ PE) , and test by flow cytometry. As shown in fig, Tebotelimab bound to huPD-1-Jurkatt cells, and the EC50 was 0.47 nM.
Tebotelimab bound to huLAG-3-CHO-K cells, and then rebounded to fluorescent secondary antibodies(Anti-Human IgG, Fcγ PE) , and test by flow cytometry. As shown in fig, Tebotelimab bound to huLAG-3-CHO-K cells, and the EC50 was 8.727 nM.
Tebotelimab bound to huPD-1-Jurkat cells, and then rebounded to fluorescent secondary antibodies(Anti-Human IgG, Fcγ PE) , and test by flow cytometry. As shown in fig, Tebotelimab bound to huPD-1-Jurkatt cells, and the EC50 was 0.47 nM.
Tebotelimab bound to huLAG-3-CHO-K cells, and then rebounded to fluorescent secondary antibodies(Anti-Human IgG, Fcγ PE) , and test by flow cytometry. As shown in fig, Tebotelimab bound to huLAG-3-CHO-K cells, and the EC50 was 8.727 nM.
The purity of Anti-LAG-3 & PD-1 Reference Antibody (Tebotelimab) is 90.76%, determined by SEC-HPLC.
Anti-LAG-3 & PD-1 Reference Antibody (Tebotelimab) on SDS-PAGE under reducing (R) condition. The purity of the protein is greater than 95%.
The detected molecular weight of Anti-LAG-3 & PD-1 Reference Antibody (Tebotelimab) is 164.05 kDa.
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