麻豆av资源_日本三级一区_www.狠狠艹_国产精妇在线观看第一区_成人性生交大片免费看中国A片_日本一本久久

掃碼關注公眾號           掃碼咨詢技術支持           掃碼咨詢技術服務
  
客服熱線:400-901-9800  客服QQ:4009019800  技術答疑  技術支持  質量反饋  關于我們  聯系我們
麻豆视频网页,国产片在线观看,丁香桃色网
首頁 > 產品中心 > 標記一抗 > 產品信息
Rabbit Anti-Bad/Biotin Conjugated antibody (bs-0892R-Bio)
訂購熱線:400-901-9800
訂購郵箱:sales@bioss.com.cn
訂購QQ:  400-901-9800
技術支持:techsupport@bioss.com.cn
說 明 書: 100ul  
100ul/2980.00元
大包裝/詢價
產品編號 bs-0892R-Bio
英文名稱 Rabbit Anti-Bad/Biotin Conjugated antibody
中文名稱 生物素標記的相關死亡促進因子Bad抗體
別    名 BBC 2; BBC2; BBC6; Bcl 2 Antagonist of Cell Death; Bcl 2 Binding Component 6; BCL X / BCL 2 Binding Protein; BCL X Binding Protein; Bcl XL/Bcl 2 Associated Death Promoter; Bcl-2-like protein 8; Bcl2 antagonist of cell death; BCL2 antagonist of cell death protein; BCL2 associated agonist of cell death; Bcl2 Associated Death Promoter; BCL2 binding component 6; BCL2 binding protein; Bcl2 Like 8 Protein; Bcl2-L-8; BCL2L8; BclXL; Proapoptotic BH3 Only Protein; BAD_HUMAN; Bcl-2-binding component 6.  
規格價格 100ul/2980元 購買        大包裝/詢價
說 明 書 100ul  
研究領域 腫瘤  細胞生物  神經生物學  信號轉導  細胞凋亡  新陳代謝  
抗體來源 Rabbit
克隆類型 Polyclonal
交叉反應 Human, Mouse, Rat, 
產品應用 WB=1:50-200 ELISA=1:100-1000 IHC-P=1:50-200 IHC-F=1:50-200 ICC=1:50-200 IF=1:50-200 
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
分 子 量 18kDa
性    狀 Lyophilized or Liquid
濃    度 1mg/ml
免 疫 原 KLH conjugated synthetic peptide derived from human Bad
亞    型 IgG
純化方法 affinity purified by Protein A
儲 存 液 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
保存條件 Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C.
產品介紹 background:
Bad is a member of the Bcl2 family and acts to promote apoptosis by forming heterodimers with the survival proteins Bcl2 and BclxL, thus preventing them from binding with BAX. Bad is found on the outer mitochondrial membrane and, once phosphorylated in response to growth stimuli, translocates to the cytoplasm. The phosphorylation status of Bad represents a key checkpoint for death or cell survival. JNK-induced phosphorylation of BAD serine 128 promotes the apoptotic role of Bad by opposing the inhibitory effect of growth factor on Bad-mediated apoptosis. Cdc2-induced phosphorylation of Bad serine 128 has an inhibitory effect on its interaction with 14-3-3 proteins. The latter interaction is critical for Bad phosphorylation at serine 155, a site within the BH3 domain that leads to the release of BclxL and the promotion of cell survival. Alternative splicing of this gene results in two transcript variants which encode the same isoform.

Function:
Promotes cell death. Successfully competes for the binding to Bcl-X(L), Bcl-2 and Bcl-W, thereby affecting the level of heterodimerization of these proteins with BAX. Can reverse the death repressor activity of Bcl-X(L), but not that of Bcl-2. Appears to act as a link between growth factor receptor signaling and the apoptotic pathways.

Subunit:
Forms heterodimers with the anti-apoptotic proteins, Bcl-X(L), Bcl-2 and Bcl-W. Also binds protein S100A10. The Ser-75/Ser-99 phosphorylated form binds 14-3-3 proteins. Interacts with AKT1 and PIM3.

Subcellular Location:
Mitochondrion outer membrane. Cytoplasm. Note=Upon phosphorylation, locates to the cytoplasm.

Tissue Specificity:
Expressed in a wide variety of tissues.

Post-translational modifications:
Phosphorylated on one or more of Ser-75, Ser-99, Ser-118 andSer-134 in response to survival stimuli, which blocks itspro-apoptotic activity. Phosphorylation on Ser-99 or Ser-75promotes heterodimerization with 14-3-3 proteins. This interactionthen facilitates the phosphorylation at Ser-118, a site within theBH3 motif, leading to the release of Bcl-X(L) and the promotion ofcell survival. Ser-99 is the major site of AKT/PKB phosphorylation, Ser-118 the major site of protein kinase A (CAPK) phosphorylation. Phosphorylation at Ser-99 by PKB/AKT1 is almost completely blockedby the apoptotic C-terminus cleavage product of PKN2 generated bycaspases-3 activity during apoptosis.
Methylation at Arg-94 and Arg-96 by PRMT1 inhibits Akt-mediated phosphorylation at Ser-99.

Similarity:
Belongs to the Bcl-2 family.

Database links:

Entrez Gene: 572 Human

Entrez Gene: 12015 Mouse

Entrez Gene: 64639 Rat

Omim: 603167 Human

SwissProt: Q92934 Human

SwissProt: Q61337 Mouse

SwissProt: O35147 Rat

Unigene: 370254 Human

Unigene: 4387 Mouse

Unigene: 36696 Rat



Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.

BAD是BCL2/BAX、BCL-XL/BAX異二聚體的負調節基因。BAD是BCL2/BCL-XL相關死亡促進因子,作為BCL2、 bCL-XL異二聚體伴分子而促進細胞凋亡。
有學者認為:BAD缺乏典型的羧基端跨膜結構,提示其并非一完整膜蛋白。與同BCL2作用相比,BAD與BCL-XL的結合更強,BAD以濃度依賴性方式替換BCL-XL/BAX、BCL2/BAX異二聚體中的BAX,使BAX游離而促進細胞凋亡。當一細胞系的所有細胞內異二聚體(BCL-XL/BAX和BCL2/BAX)的含量≥50%時,則細胞耐受凋亡;而當細胞內BAX同二聚體>80%時且在適當信號誘導下則細胞出現凋亡。這表明BAD通過調節BAX同二聚體與異二聚體量的比值而介導凋亡。
版權所有 2004-2026 m.jywcc.com 北京博奧森生物技術有限公司
通過國際質量管理體系ISO 9001:2015 GB/T 19001-2016    證書編號: 00124Q34771R2M/1100
通過國際醫療器械-質量管理體系ISO 13485:2016 GB/T 42061-2022    證書編號: CQC24QY10047R0M/1100
京ICP備05066980號-1         京公網安備110107000727號
主站蜘蛛池模板: 最近2018中文字幕免费看2019 | 欧洲成人一区二区 | 超爱碰在线资源 | 久久久国产毛片 | 久久久久无码国产精品一区乞丐 | 人人干天天操 | 亚洲宅男一区 | 黄视频网站在线看 | 88av中文字幕 | 不卡影院一区二区 | 国产精品天天干 | 国产精品亚洲欧美一区麻豆 | 欧美日韩视频一区二区三区 | 久久精品视频免费播放 | 久久亚洲精品无码Va白人极品 | 亚洲国产另类久久久精品小说 | 久草福利资源在线 | 无码免费毛片手机在线无卡顿 | av在线a | 日本公与丰满熄理论在线播放 | 无码中文人妻在线一区二区三区 | 国产美女AV一区二区三区 | 亚洲中文字幕成人无码 | 国产成人无码免费视频在线 | 视频一区二区免费 | 蜜臀人妻精品一区二区免费 | 无码国产午夜福利片在线观看 | 天堂成人国产精品一区 | 国产在线视欧美亚综合 | 国产视色精品亚洲一区二区 | 亚洲伦理中文字幕 | 成人一区二区在线 | 国产白浆二区二区精品视频 | 欧美日韩免费做爰大片人 | 狠狠干视频网 | 免费看黄色a级片 | 欧美日韩国产精品一区 | 337p欧美顶级日本大片 | 日韩精美视频 | yy8840私人影院的在线 | 福利姬一区二区三区在线观看 |