麻豆av资源_日本三级一区_www.狠狠艹_国产精妇在线观看第一区_成人性生交大片免费看中国A片_日本一本久久

掃碼關(guān)注公眾號(hào)           掃碼咨詢技術(shù)支持           掃碼咨詢技術(shù)服務(wù)
  
客服熱線:400-901-9800  客服QQ:4009019800  技術(shù)答疑  技術(shù)支持  質(zhì)量反饋  關(guān)于我們  聯(lián)系我們
韩国三级大全久久网站,免费观看黄页网站,欧美国产精品日韩在线
Rabbit Anti-CD46/PE-Cy5 Conjugated antibody (bs-1529R-PE-Cy5)
訂購(gòu)熱線:400-901-9800
訂購(gòu)郵箱:sales@bioss.com.cn
訂購(gòu)QQ:  400-901-9800
技術(shù)支持:techsupport@bioss.com.cn
說(shuō) 明 書(shū): 100ul  
100ul/2980.00元
大包裝/詢價(jià)
產(chǎn)品編號(hào) bs-1529R-PE-Cy5
英文名稱 Rabbit Anti-CD46/PE-Cy5 Conjugated antibody
中文名稱 PE-Cy5標(biāo)記的膜輔蛋白抗體
別    名 CD46 antigen; CD46 molecule; CD46 molecule complement regulatory protein; Complement membrane cofactor protein; MCP; Measles virus receptor; Membrane cofactor protein; Membrane cofactor protein precursor; MIC 10; MIC10; TLX; TRA2.10; Trophoblast leucocyte common antigen; Trophoblast lymphocyte cross reactive antigen; Antigen identified by monoclonal antibody TRA 2 10; MCP_HUMAN; membrane cofactor protein isoform 1 precursor.  
規(guī)格價(jià)格 100ul/2980元 購(gòu)買        大包裝/詢價(jià)
說(shuō) 明 書(shū) 100ul  
研究領(lǐng)域 免疫學(xué)  糖蛋白  
抗體來(lái)源 Rabbit
克隆類型 Polyclonal
交叉反應(yīng) Human, Mouse, 
產(chǎn)品應(yīng)用 Flow-Cyt=1:50-200 ICC=1:50-200 IF=1:50-200 
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
分 子 量 43kDa
性    狀 Lyophilized or Liquid
濃    度 1mg/ml
免 疫 原 KLH conjugated synthetic peptide derived from human CD46
亞    型 IgG
純化方法 affinity purified by Protein A
儲(chǔ) 存 液 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
保存條件 Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C.
產(chǎn)品介紹 background:
The protein encoded by this gene is a type I membrane protein and is a regulatory part of the complement system. The encoded protein has cofactor activity for inactivation of complement components C3b and C4b by serum factor I, which protects the host cell from damage by complement. In addition, the encoded protein can act as a receptor for the Edmonston strain of measles virus, human herpesvirus-6, and type IV pili of pathogenic Neisseria. Finally, the protein encoded by this gene may be involved in the fusion of the spermatozoa with the oocyte during fertilization. Mutations at this locus have been associated with susceptibility to hemolytic uremic syndrome. Alternatively spliced transcript variants encoding different isoforms have been described. [provided by RefSeq, Jun 2010].

Function:
Acts as a cofactor for complement factor I, a serine protease which protects autologous cells against complement-mediated injury by cleaving C3b and C4b deposited on host tissue. May be involved in the fusion of the spermatozoa with the oocyte during fertilization. Also acts as a costimulatory factor for T-cells which induces the differentiation of CD4+ into T-regulatory 1 cells. T-regulatory 1 cells suppress immune responses by secreting interleukin-10, and therefore are thought to prevent autoimmunity. A number of viral and bacterial pathogens seem to exploit this property and directly induce an immunosuppressive phenotype in T-cells by binding to CD46.

Subunit:
Interacts with C3b and C4b. Binds to Measles virus H protein, to Human herpesvirus 6 GH protein and to human adenovirus B/D PIV/fiber protein, and acts as a receptor for these viruses. Binds to Streptococcus pyogenes M protein and to type IV pili from Neisseria, and may act as a receptor for these pathogenic bacteria.

Subcellular Location:
Cytoplasmic vesicle, secretory vesicle, acrosome inner membrane; Single-pass type I membrane protein. Note=Inner acrosomal membrane of spermatozoa. Internalized upon binding of Measles virus, Herpesvirus 6 or Neisseria gonorrhoeae, which results in an increased susceptibility of infected cells to complement-mediated injury. In cancer cells or cells infected by Neisseria, shedding leads to a soluble peptide.

Tissue Specificity:
Expressed by all cells except erythrocytes.

Post-translational modifications:
N-glycosylated on Asn-83; Asn-114 and Asn-273 in most tissues, but probably less N-glycosylated in testis. N-glycosylation on Asn-114 and Asn-273 is required for cytoprotective function. N-glycosylation on Asn-114 is required for Measles virus binding. N-glycosylation on Asn-273 is required for Neisseria binding. N-glycosylation is not required for human adenovirus binding.
Extensively O-glycosylated in the Ser/Thr-rich domain. O-glycosylation is required for Neisseria binding but not for Measles virus or human adenovirus binding.
In epithelial cells, isoforms B/D/F/H/J/L/3 are phosphorylated by YES1 in response to infection by Neisseria gonorrhoeae; which promotes infectivity. In T-cells, these isoforms may be phosphorylated by Lck.

DISEASE:
Defects in CD46 are a cause of susceptibility to hemolytic uremic syndrome atypical type 2 (AHUS2) [MIM:612922]. An atypical form of hemolytic uremic syndrome. It is a complex genetic disease characterized by microangiopathic hemolytic anemia, thrombocytopenia, renal failure and absence of episodes of enterocolitis and diarrhea. In contrast to typical hemolytic uremic syndrome, atypical forms have a poorer prognosis, with higher death rates and frequent progression to end-stage renal disease. Note=Susceptibility to the development of atypical hemolytic uremic syndrome can be conferred by mutations in various components of or regulatory factors in the complement cascade system. Other genes may play a role in modifying the phenotype. Patients with CD46 mutations seem to have an overall better prognosis compared to patients carrying CFH mutations.

Similarity:
Contains 4 Sushi (CCP/SCR) domains.

Database links:

Entrez Gene: 4179 Human

Entrez Gene: 17221 Mouse

Entrez Gene: 29333 Rat

Omim: 120920 Human

SwissProt: P15529 Human

SwissProt: O88174 Mouse

SwissProt: Q9Z0M4 Rat

Unigene: 510402 Human

Unigene: 12884 Mouse

Unigene: 163242 Rat



Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.

MCP為一單鏈穿膜糖蛋白,是補(bǔ)體系統(tǒng)的一種新的調(diào)節(jié)蛋白,是內(nèi)源性輔助因子活性蛋白,屬于RCA基因簇的成員。CD46通過(guò)GPI錨固定于細(xì)胞上。MCP的細(xì)胞分布廣范,在粒細(xì)胞、血小板、T細(xì)胞(Th、Ts、Tc)、B細(xì)胞、NK細(xì)胞、造血細(xì)胞系、成纖維細(xì)胞、表皮細(xì)胞、內(nèi)皮細(xì)胞及星狀膠質(zhì)細(xì)胞等都有分布。
版權(quán)所有 2004-2026 m.jywcc.com 北京博奧森生物技術(shù)有限公司
通過(guò)國(guó)際質(zhì)量管理體系ISO 9001:2015 GB/T 19001-2016    證書(shū)編號(hào): 00124Q34771R2M/1100
通過(guò)國(guó)際醫(yī)療器械-質(zhì)量管理體系ISO 13485:2016 GB/T 42061-2022    證書(shū)編號(hào): CQC24QY10047R0M/1100
京ICP備05066980號(hào)-1         京公網(wǎng)安備110107000727號(hào)
主站蜘蛛池模板: 亚洲性爰| 狠狠亚洲婷婷综合色香五月 | 在线看片一区 | 免费一级特黄毛片视频 | 久久久免费看视频 | 一区二区片| 国产特级全黄一级97毛片 | 欧美性色aⅴ视频一区日韩精品 | 永夜星河在线免费观看 | 国产精品人妻一区二区三区a | 色老板精品视频在线观看 | 亚洲女同精品一区二区 | 91av小视频 | 性欧美亚洲xxxx乳在线观看 | yw855.ccm免费观看网址 | 最近中文字幕MV高清在线视频 | 日韩伦理久久 | 国产拍揄自揄精品视频 | 国产精品久久精品99国产百盛 | 高清偷自拍亚洲精品三区 | 欧美日韩国产精品久久久久 | 99久久久国产精品免费调教网站 | 老司机精品在线视频 | 综合久久给合久久狠狠狠97色 | 无码中文字幕人妻在线一区二区三区 | 6精品国产乱码久久久久久 成人AAA片一区国产精品 | 杨幂ai换脸视频 | 国产精品第3页 | 国产一区二区欧美日韩 | 成人涩涩 | 97日日碰曰曰摸日日澡 | 久久99精品热在线观看 | 日本高清www| 国产日韩欧美一区二区乱码 | 亚洲午夜精品久久 | 国内毛片毛片毛片毛片 | 成人精品玖玖资源在线播放 | 亚洲精品16p | 美女扒开尿眼让男人桶爽视频 | 久久美女高清视频 | 一边啪啪一边呻吟AV夜夜嗨 |