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Rabbit Anti-GLP-1R/PE-Cy5.5 Conjugated antibody (bs-1559R-PE-Cy5.5)
訂購熱線:400-901-9800
訂購郵箱:sales@bioss.com.cn
訂購QQ:  400-901-9800
技術支持:techsupport@bioss.com.cn
說 明 書: 100ul  
100ul/2980.00元
大包裝/詢價
產品編號 bs-1559R-PE-Cy5.5
英文名稱 Rabbit Anti-GLP-1R/PE-Cy5.5 Conjugated antibody
中文名稱 PE-Cy5.5標記的胰高血糖素樣肽-1受體/GLP-1受體抗體
別    名 Glucagon like peptide-1 receptor; GLP 1 R; GLP 1 receptor; GLP 1R; Glp1r; GLP; glp1r; Glucagon like peptide 1 receptor; RATGL1RCP; Glip;MGC138331; GLP-1-R; GLP1R_HUMAN; Glucagon-like peptide 1 receptor; GLP-1 receptor; GLP-1-R; GLP-1R; Precursor.  
規(guī)格價格 100ul/2980元 購買        大包裝/詢價
說 明 書 100ul  
研究領域 免疫學  生長因子和激素  糖尿病  
抗體來源 Rabbit
克隆類型 Polyclonal
交叉反應 Human, Mouse, Rat,  (predicted: Dog, )
產品應用 ICC=1:50-200 IF=1:50-200 
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
分 子 量 51kDa
性    狀 Lyophilized or Liquid
濃    度 1mg/ml
免 疫 原 KLH conjugated synthetic peptide derived from human GLP-1R C-terminus
亞    型 IgG
純化方法 affinity purified by Protein A
儲 存 液 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
保存條件 Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C.
產品介紹 background:
GLP1R is a receptor for glucagon-like peptide 1. The activity of this receptor is mediated by G proteins which activate adenylyl cyclase.It has been suggested that this protein influences the feelings of satiety or hunger, sensation of glucose levels, control of glucagon sensitivity of islets, and non insulin-dependent diabetes mellitus. GLP1R is believed to be expressed in human pancreas,lung, brain, stomach, kidney and heart. ESTs have been isolated from skin and kidney libraries.

Function:
This is a receptor for glucagon-like peptide 1. The activity of this receptor is mediated by G proteins which activate adenylyl cyclase.

Subunit:
May form homodimers and heterodimers with GIPR.

Subcellular Location:
Cell membrane; Multi-pass membrane protein.

Post-translational modifications:
N-glycosylation enhances cell surface expression and lengthens receptor half-life by preventing degradation in the ER.

Similarity:
Belongs to the G-protein coupled receptor 2 family.

Database links:

Entrez Gene: 2740 Human

Entrez Gene: 14652 Mouse

Entrez Gene: 25051 Rat

Omim: 138032 Human

SwissProt: P43220 Human

SwissProt: O35659 Mouse

SwissProt: P32301 Rat

Unigene: 389103 Human

Unigene: 390969 Mouse

Unigene: 11408 Rat



Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.

GLP-1R是GLP-1在體內作用的主要靶點,它是一個7次跨膜的G蛋白偶聯(lián)受體,以cAMP為主要第二信使。GLP-1與GLP-1R結合過程是一個兩結構域相互作用的過程,都與胰島素分泌和糖代謝調節(jié)密切相關。
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