麻豆av资源_日本三级一区_www.狠狠艹_国产精妇在线观看第一区_成人性生交大片免费看中国A片_日本一本久久

掃碼關注公眾號           掃碼咨詢技術支持           掃碼咨詢技術服務
  
客服熱線:400-901-9800  客服QQ:4009019800  技術答疑  技術支持  質量反饋  關于我們  聯系我們
久久久亚洲精品一区二区三区 ,亚洲视频你懂的,天天躁日日躁aaaa视频
首頁 > 產品中心 > 標記一抗 > 產品信息
Rabbit Anti-Cyclin E1/BF350 Conjugated antibody (bs-0573R-BF350)
訂購熱線:400-901-9800
訂購郵箱:sales@bioss.com.cn
訂購QQ:  400-901-9800
技術支持:techsupport@bioss.com.cn
說 明 書: 100ul  
100ul/2980.00元
大包裝/詢價
產品編號 bs-0573R-BF350
英文名稱 Rabbit Anti-Cyclin E1/BF350 Conjugated antibody
中文名稱 BF350標記的周期素E抗體
別    名 CCNE 1; CCNE; CCNE1; Cyclin E1; Cyclin Es; Cyclin Et; CyclinE; G1/S specific cyclin E; G1/S-specific cyclin-E1; CCNE1_HUMAN.  
規格價格 100ul/2980元 購買        大包裝/詢價
說 明 書 100ul  
研究領域 細胞生物  細胞周期蛋白  
抗體來源 Rabbit
克隆類型 Polyclonal
交叉反應 (predicted: Mouse, Rat, )
產品應用 IF=1:50-200 
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
分 子 量 45kDa
性    狀 Lyophilized or Liquid
濃    度 1mg/ml
免 疫 原 KLH conjugated synthetic peptide derived from rat Cyclin E
亞    型 IgG
純化方法 affinity purified by Protein A
儲 存 液 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol
保存條件 Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C.
產品介紹 background:
The protein encoded by this gene belongs to the highly conserved cyclin family, whose members are characterized by a dramatic periodicity in protein abundance through the cell cycle. Cyclins function as regulators of CDK kinases. Different cyclins exhibit distinct expression and degradation patterns which contribute to the temporal coordination of each mitotic event. This cyclin forms a complex with and functions as a regulatory subunit of CDK2, whose activity is required for cell cycle G1/S transition. This protein accumulates at the G1-S phase boundary and is degraded as cells progress through S phase. Overexpression of this gene has been observed in many tumors, which results in chromosome instability, and thus may contribute to tumorigenesis. This protein was found to associate with, and be involved in, the phosphorylation of NPAT protein (nuclear protein mapped to the ATM locus), which participates in cell-cycle regulated histone gene expression and plays a critical role in promoting cell-cycle progression in the absence of pRB. Two alternatively spliced transcript variants of this gene, which encode distinct isoforms, have been described. Two additional splice variants were reported but detailed nucleotide sequence information is not yet available. Transcript Variant: This variant (1) contains a different 5' end region, which includes an upstream in-frame translation start codon, when compared to variant 2. The encoded protein has a 15 aa longer N-terminus, as compared to isoform 2.

Subunit:
Interacts with a member of the CDK2/CDK protein kinases to form a serine/threonine kinase holoenzyme complex. The cyclin subunit imparts substrate specificity to the complex. Found in a complex with CDK2, CABLES1 and CCNA1 (By similarity). Part of a complex consisting of UHRF2, CDK2 and CCNE1. Interacts directly with UHRF2; the interaction ubiquitinates CCNE1 and appears to occur independently of CCNE1 phosphorylation.

Subcellular Location:
Nucleus.

Tissue Specificity:
Highly expressed in testis and placenta. Low levels in bronchial epithelial cells.

Post-translational modifications:
Phosphorylation of Thr-395 by GSK3 and of Ser-399 by CDK2 accelerates degradation via the ubiquitin proteasome pathway. Phosphorylated upon DNA damage, probably by ATM or ATR.

Similarity:
Belongs to the cyclin family. Cyclin E subfamily.

Database links:

Entrez Gene: 898 Human

Entrez Gene: 12447 Mouse

Entrez Gene: 25729 Rat

Omim: 123837 Human

SwissProt: P24864 Human

SwissProt: Q61457 Mouse

SwissProt: P39949 Rat

Unigene: 244723 Human

Unigene: 16110 Mouse

Unigene: 15455 Rat



Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.


細胞周期素E是調控細胞G-1→S期轉變的關鍵因素。由于在多種腫瘤中的不適當表達,細胞周期素E現在已明確為原癌基因。
版權所有 2004-2026 m.jywcc.com 北京博奧森生物技術有限公司
通過國際質量管理體系ISO 9001:2015 GB/T 19001-2016    證書編號: 00124Q34771R2M/1100
通過國際醫療器械-質量管理體系ISO 13485:2016 GB/T 42061-2022    證書編號: CQC24QY10047R0M/1100
京ICP備05066980號-1         京公網安備110107000727號
主站蜘蛛池模板: h视频免费在线 | 在线中文日韩 | 欧美久久综合网 | 顶级欧美熟妇XX | 又色又爽又大免费区欧美 | 亚洲欧美精品伊人久久 | 欧美午夜精选久久久A | 日日摸夜夜添夜夜添无码免费视频 | 国产精品精品久久久久久潘金莲 | 国产在线一二区 | 免费观看全黄做爰大片国产 | 日韩毛片欧美一级a | 色久综合网 | 成人A片免费视频在线观看1 | 亚洲国产av无码综合原创国产 | 欧美黑人群一交 | 亚洲熟妇无码八V在线播放 日韩精品中文字幕久久臀 久久久久人妻一区精品性色AV | 久久久av片| 欧美做a视频 | 亚洲中文字幕aⅴ无码天堂 亚洲美女一区二区三区 | 欧美日韩亚洲国产 | 中文字幕熟妇在线观看 | 麻豆视频国产在线观看 | 久久久国产精品网站 | 精品乱码一区内射人妻无码 | 久久国产色av老熟蜜臀av | 蜜乳av片 | 黑人黄色片 | 日韩色网址 | 四虎在线视频免费观看 | 国产日韩欧美东南在线 | 亚洲视频一区二区 | 中文字幕日本人妻久久久免费 | 特级丰满少妇一级aaaa爱毛片 | 中文字幕在线观看网址 | 东北老头嫖妓猛对白精彩 | 奶茶视频有容乃大海纳百川有容乃大绿巨人 | 亚洲乱码av中文一二区软件 | 久久另类ts人妖一区二区 | 国产裸体美女永久免费无遮挡 | 亚洲九九九九 |