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Rabbit Anti-GDF15/BF488 Conjugated antibody (bs-3818R-BF488)
訂購熱線:400-901-9800
訂購郵箱:sales@bioss.com.cn
訂購QQ:  400-901-9800
技術支持:techsupport@bioss.com.cn
說 明 書: 100ul  
100ul/2980.00元
大包裝/詢價
產品編號 bs-3818R-BF488
英文名稱 Rabbit Anti-GDF15/BF488 Conjugated antibody
中文名稱 BF488標記的生長分化因子15/巨嗜細胞抑制因子1抗體
別    名 GDF 15; GDF-15 Growth differentiation factor 15; Growth/differentiation factor 15; Macrophage inhibitory cytokine 1; MIC 1; MIC-1; MIC1; NAG 1; NAG1; NRG 1; NRG1; NSAID (nonsteroidal anti inflammatory drug) activated protein 1; NSAID; NSAID regulated protein 1; PDF; PLAB; Placental bone morphogenetic protein; Placental bone morphogenic protein; Placental TGF beta; placental transformation growth factor beta; Prostate differentiation factor; PTGF beta; PTGFB; prostate derived factor.   
規格價格 100ul/2980元 購買        大包裝/詢價
說 明 書 100ul  
研究領域 腫瘤  細胞生物  免疫學  信號轉導  細胞凋亡  生長因子和激素  轉錄調節因子  
抗體來源 Rabbit
克隆類型 Polyclonal
交叉反應 Human, Mouse,  (predicted: Rat, )
產品應用 IF=1:50-200 
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
分 子 量 12.5/34kDa
性    狀 Lyophilized or Liquid
濃    度 1mg/ml
免 疫 原 KLH conjugated synthetic peptide derived from human GDF-15
亞    型 IgG
純化方法 affinity purified by Protein A
儲 存 液 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol
保存條件 Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C.
產品介紹 background:
Growth differentiation factor 15 (GDF15) is a member of the bone morphogenetic protein (BMP) family and the TGF-beta superfamily. It has been implicated in a variety of functions directly related to tumorigenicity including antiproliferative and pro-apoptotic effects. BMP proteins are secreted growth factors that are characterized by seven conserved cysteine residues. In general, they are regulators of cell growth and differentiation in both embryonic and adult tissues. GDF15 is an important downstream mediator of DNA damage signaling and a transcriptional target of p53.

Subcellular Location:
Secreted.

Tissue Specificity:
Highly expressed in placenta, with lower levels in prostate and colon and some expression in kidney.

Similarity:
Belongs to the TGF-beta family.

Database links:

Entrez Gene: 9518 Human

Entrez Gene: 23886 Mouse

Entrez Gene: 29455 Rat

Omim: 605312 Human

SwissProt: Q99988 Human

SwissProt: Q9Z0J7 Mouse

SwissProt: Q9Z0J6 Rat

Unigene: 616962 Human

Unigene: 31325 Mouse

Unigene: 44228 Rat



Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.

生長分化因子15(GDF15)是骨形態發生蛋白(BMP)和轉化生長因子-β超家族成員。GDF-15又叫巨噬細胞抑制因子(macrophage inhibiting cytokine,MIC)-1、胎盤轉化生長因子 (placental transformation growth factor,PTGF)-β、前列腺衍生因子(prostate derived factor,PDF)和胎盤骨形態發生蛋白(placental bone morphogeneticprotein,PLAB)。
有學者認為:GDF-15在腫瘤發展的不同階段發揮著不同的生物學作用;隨著腫瘤的發生發展,GDF-15可能表達不同形式的蛋白,在腫瘤發生的早期階段可能發揮抑瘤作用,而在腫瘤發展的后期階段發揮促瘤作用。
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