麻豆av资源_日本三级一区_www.狠狠艹_国产精妇在线观看第一区_成人性生交大片免费看中国A片_日本一本久久

掃碼關注公眾號           掃碼咨詢技術支持           掃碼咨詢技術服務
  
客服熱線:400-901-9800  客服QQ:4009019800  技術答疑  技術支持  質量反饋  關于我們  聯(lián)系我們
无码人妻精品一区二区三区久久久,成全影视在线观看第6季,免费A级毛片无码A∨性按摩
首頁 > 產(chǎn)品中心 > 標記一抗 > 產(chǎn)品信息
Rabbit Anti-RAGE/Cy5 Conjugated antibody (bs-0177R-Cy5)
訂購熱線:400-901-9800
訂購郵箱:sales@bioss.com.cn
訂購QQ:  400-901-9800
技術支持:techsupport@bioss.com.cn
說 明 書: 100ul  
100ul/2980.00元
大包裝/詢價
產(chǎn)品編號 bs-0177R-Cy5
英文名稱 Rabbit Anti-RAGE/Cy5 Conjugated antibody
中文名稱 Cy5標記的晚期糖基化終末產(chǎn)物特異性受體抗體
別    名 Advanced glycosylation end product specific receptor; Advanced glycosylation end product-specific receptor; AGER; EC 2.7.11.22; LE 9211 A antigen;LE-9211-A antigen; MGC22357; MOK; RAGE 1; RAGE1; MOK protein kinase; Receptor for advanced glycation endproducts;Renal tumor antigen 1; Renal tumor antigen; Renal cell carcinoma antigen (MOK protein kinase); Renal tumor antigen 1; RAGE_HUMAN.  
規(guī)格價格 100ul/2980元 購買        大包裝/詢價
說 明 書 100ul  
研究領域 腫瘤  心血管  免疫學  生長因子和激素  糖尿病  內分泌病  
抗體來源 Rabbit
克隆類型 Polyclonal
交叉反應 Mouse, Rat,  (predicted: Human, )
產(chǎn)品應用 Flow-Cyt=1:50-200 ICC=1:50-200 IF=1:50-200 
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
分 子 量 42kDa
性    狀 Lyophilized or Liquid
濃    度 1mg/ml
免 疫 原 KLH conjugated synthetic peptide derived from rat AGER
亞    型 IgG
純化方法 affinity purified by Protein A
儲 存 液 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
保存條件 Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C.
產(chǎn)品介紹 background:
Advanced glycosylation end product-specific receptor (AGER; RAGE) is a member of the immunoglobulin superfamily of cell surface molecules that binds molecules that have been irreversibly modified by non-enzymatic glycation and oxidation, and are know as advanced glycation end products (AGEs). It is expressed by endothelium, mononuclear phagocytes, neurons and smooth muscle cells. Whereas RAGE is present at high levels during development, especially in the central nervous system, its levels decline during maturity.The increased expression of RAGE is associated with several pathological states, such as diabetic vasculopathy, neuropathy, retinopathy and other disorders, including Alzheimer's disease and immune/inflammatory reactions of the vessel walls. In diabetic tissues, the production of RAGE is due to the overproduction of AGEs that eventually overwhelm the protective properties of RAGE. This results in oxidative stress and endothelial cell dysfunction that leads to vascular disease in diabetics. In the brain, RAGE also binds amyloid beta (Ab). Because Ab is overproduced in neurons and vessels in the brains of Alzheimer disease, this leads to the hyperstimulation of RAGE. The RAGE-Ab interaction is thought to result in oxidative stress leading to neuronal degeneration.

Function:
Mediates interactions of advanced glycosylation end products (AGE). These are nonenzymatically glycosylated proteins which accumulate in vascular tissue in aging and at an accelerated rate in diabetes. Acts as a mediator of both acute and chronic vascular inflammation in conditions such as atherosclerosis and in particular as a complication of diabetes. AGE/RAGE signaling plays an important role in regulating the production/expression of TNF-alpha, oxidative stress, and endothelial dysfunction in type 2 diabetes. Interaction with S100A12 on endothelium, mononuclear phagocytes, and lymphocytes triggers cellular activation, with generation of key proinflammatory mediators. Receptor for amyloid beta peptide. Contributes to the translocation of amyloid-beta peptide (ABPP) across the cell membrane from the extracellular to the intracellular space in cortical neurons. ABPP-initiated RAGE signaling, especially stimulation of p38 mitogen-activated protein kinase (MAPK), has the capacity to drive a transport system delivering ABPP as a complex with RAGE to the intraneuronal space. Interaction with S100B after myocardial infarction may play a role in myocyte apoptosis by activating ERK1/2 and p53/TP53 signaling.

Subunit:
Interacts with S100B, S100A1 and APP. Interacts with S100A12.

Subcellular Location:
Isoform 1: Cell membrane; Single-pass type I membrane protein.
Isoform 2: Secreted.

Tissue Specificity:
Endothelial cells and cardiomyocytes.

Similarity:
Contains 2 Ig-like C2-type (immunoglobulin-like) domains.
Contains 1 Ig-like V-type (immunoglobulin-like) domain.

Database links:

Entrez Gene: 177 Human

Entrez Gene: 11596 Mouse

Entrez Gene: 81722 Rat

Omim: 600214 Human

SwissProt: Q15109 Human

SwissProt: Q62151 Mouse

SwissProt: Q63495 Rat

Unigene: 534342 Human

Unigene: 3383 Mouse

Unigene: 9829 Rat



Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.

晚期糖基化終末產(chǎn)物受體(AGER)與其配體AGEs形成的AGEs-AGER 系統(tǒng)在糖尿病血管病變的發(fā)生、發(fā)展過程中起著重要作用.
年齡及晚期糖基化終末產(chǎn)物(AGEs)等多種因素均能調節(jié)AGER基因的表達. 糖尿病患者體內晚期糖基化終末產(chǎn)物受體(AGER)的高表達加速了病人血管病變的發(fā)展過程,并增加了病變的復雜性.阻斷AGER通路可緩解糖尿病血管的病變過程。
因此,AGER可以作為治療糖尿病血管病變的藥物靶點,并為臨床治療糖尿病血管病變提供了新的思路.
版權所有 2004-2026 m.jywcc.com 北京博奧森生物技術有限公司
通過國際質量管理體系ISO 9001:2015 GB/T 19001-2016    證書編號: 00124Q34771R2M/1100
通過國際醫(yī)療器械-質量管理體系ISO 13485:2016 GB/T 42061-2022    證書編號: CQC24QY10047R0M/1100
京ICP備05066980號-1         京公網(wǎng)安備110107000727號
主站蜘蛛池模板: 台湾一级毛片永久免费 | 国产精品久久不射 | 少妇性xxxxxxxxx色 | 免费裸体无遮挡黄网站免费看 | 斗罗大陆3龙王传说第四季免费观看 | 亚洲婷婷一区二区三区在线观看 | 一本AV高清一区二区三区 | 三年片免费观看在线播放动漫 | 尤物九九久久国产精品的分类 | 亚洲精品乱码久久久久久蜜桃动漫 | 国产91av视频在线观看 | 亚洲爆乳中文字幕无码专区网站 | 丁香色五月国产在线视频 | 欧美视频网站 | 午夜男女爽爽爽在线视频 | 久久久久久久美国产毛片 | 亚洲三级片福利视频 | 国产一级av片一区久久久 | 国产精品久久久久久久免费A片 | 黄色a在线 | 国产久免费热视频在线观看 | 成人少妇影院yyyy | 日韩大片在线永久免费观看网站 | 一区二区三区日韩精品视频 | av一区二区三区四区 | 黄色网站免费观看视频 | 国产视频在线免费观看 | 日本丰满岳乱妇在线观看 | 亚洲手机看片 | 午夜亚洲影视 | 青青草视频在线看 | 一级视频在线 | 亚洲首页一区任你躁XXXXX | 国产精品国产a | 黑色蕾丝丝袜麻麻好紧好爽 | 日日干日日摸 | 国产香蕉97碰碰视频碰碰看 | 无码高潮爽到爆的喷水视频 | 免费一级全黄少妇性色生活片 | 日本久久国产 | 欧美在线播放一区二区三区 |