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Rabbit Anti-Nrf2/BF647 Conjugated antibody (bs-1074R-BF647)
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說 明 書: 100ul  
100ul/2980.00元
大包裝/詢價

產品編號 bs-1074R-BF647
英文名稱 Rabbit Anti-Nrf2/BF647 Conjugated antibody
中文名稱 BF647標記的核因子2相關因子2抗體
別    名 Nuclear factor-E2 related factor2; Nrf-2; HEBP1; NF E2 related factor 2; NFE2 related factor 2; NFE2L2; Nrf 2; Nuclear factor erythroid 2 related factor 2; Nuclear factor erythroid derived 2 like 2; NF2L2_HUMAN.  
規格價格 100ul/2980元 購買        大包裝/詢價
說 明 書 100ul  
研究領域 腫瘤  免疫學  染色質和核信號  合成與降解  
抗體來源 Rabbit
克隆類型 Polyclonal
交叉反應 Human, Mouse, Rat,  (predicted: Chicken, Dog, Cow, Horse, Rabbit, )
產品應用 IF=1:50-200 
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
分 子 量 68kDa
性    狀 Lyophilized or Liquid
濃    度 1mg/ml
免 疫 原 KLH conjugated synthetic peptide derived from human Nrf2
亞    型 IgG
純化方法 affinity purified by Protein A
儲 存 液 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
保存條件 Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C.
產品介紹 background:
Transcription activator that binds to antioxidant response (ARE) elements in the promoter regions of target genes. Important for the coordinated up-regulation of genes in response to oxidative stress. May be involved in the transcriptional activation of genes of the beta-globin cluster by mediating enhancer activity of hypersensitive site 2 of the beta-globin locus control region.

Function:
Transcription activator that binds to antioxidant response (ARE) elements in the promoter regions of target genes. Important for the coordinated up-regulation of genes in response to oxidative stress. May be involved in the transcriptional activation of genes of the beta-globin cluster by mediating enhancer activity of hypersensitive site 2 of the beta-globin locus control region.

Subunit:
Heterodimer. May bind DNA with an unknown protein. Interacts with KEAP1. Interacts via its leucine-zipper domain with the coiled-coil domain of PMF1.

Subcellular Location:
Cytoplasm, cytosol. Nucleus. Note=Cytosolic under unstressed conditions, translocates into the nucleus upon induction by electrophilic agents.

Tissue Specificity:
Widely expressed. Highest expression in adult muscle, kidney, lung, liver and in fetal muscle.

Post-translational modifications:
Phosphorylation of Ser-40 by PKC in response to oxidative stress dissociates NFE2L2 from its cytoplasmic inhibitor KEAP1, promoting its translocation into the nucleus.

Similarity:
Belongs to the bZIP family. CNC subfamily.
Contains 1 bZIP domain.

Database links:

Entrez Gene: 4780 Human

Omim: 600492 Human

SwissProt: Q16236 Human



Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.

轉錄調節因子(Transcriptin Regulators) 核細胞系因子2相關因子Nrf2,是一種對氧化還原反應敏感的轉錄因子,可以通過正向促進基因的表達,來轉錄翻譯產生一些抗氧化物,行使著異化解毒的酶類和藥物的高效外排泵作用。
有學者認為:核因子2相關因子2蛋白在保護細胞免受環境毒性物質影響方面發揮著極其重要的作用,它指導某些基因促進細胞的防御工事,同時也刺激某些重要解毒酶對毒性物質,如黃曲霉素的解毒和排毒作用。
產品圖片
Paraformaldehyde-fixed, paraffin embedded Human Testicles; Antigen retrieval by boiling in sodium citrate buffer (pH6.0) for 15 min; Incubation:Nrf2Antibody, conjugated (bs-1074R-BF647) at 1:200 overnight at 4°C; DAPI (blue, C02-04002) was used to stain the cell nuclei.
Paraformaldehyde-fixed, paraffin embedded Mouse Testicles; Antigen retrieval by boiling in sodium citrate buffer (pH6.0) for 15 min; Incubation:Nrf2Antibody, conjugated (bs-1074R-BF647) at 1:200 overnight at 4°C; DAPI (blue, C02-04002) was used to stain the cell nuclei.
Paraformaldehyde-fixed, paraffin embedded Rat Testicles; Antigen retrieval by boiling in sodium citrate buffer (pH6.0) for 15 min; Incubation:Nrf2Antibody, conjugated (bs-1074R-BF647) at 1:200 overnight at 4°C; DAPI (blue, C02-04002) was used to stain the cell nuclei.
The Hela ( treated with MG-132 (10 μM,10 h)) (H) cells were fixed with 4% PFA (10 min at r.t.) and then permeabilized with 90% ice-cold methanol for 20 min at -20℃,the cells then were incubated in 5%BSA to block non-specific protein-protein interactions (30 min at r.t.).Primary Antibody (green): BF647 conjugated Rabbit Anti-Nrf2 antibody (bs-1074R-BF647): 1 μg/10^6 cells. Blank control (black): PBS. Acquisition of 20,000 events was performed.
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