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Rabbit Anti-RSV Major surface glycoprotein G/HRP Conjugated antibody (bs-1264R-HRP)
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說 明 書: 100ul  
100ul/2980.00元
大包裝/詢價
產品編號 bs-1264R-HRP
英文名稱 Rabbit Anti-RSV Major surface glycoprotein G/HRP Conjugated antibody
中文名稱 辣根過氧化物酶標記的呼吸道合胞病毒抗體
別    名 RS virus; RSV; GLYC_HRSVA; Major surface glycoprotein G; Attachment glycoprotein G; Membrane-bound glycoprotein; mG; G.  
規格價格 100ul/2980元 購買        大包裝/詢價
說 明 書 100ul  
研究領域 細胞生物  免疫學  細菌及病毒  
抗體來源 Rabbit
克隆類型 Polyclonal
交叉反應
產品應用 IHC-P=1:50-200 IHC-F=1:50-200 
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
分 子 量 33kDa
性    狀 Lyophilized or Liquid
濃    度 1mg/ml
免 疫 原 KLH conjugated synthetic peptide derived from Human respiratory syncytial virus A2
亞    型 IgG
純化方法 affinity purified by Protein A
儲 存 液 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
保存條件 Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C.
產品介紹 background:
Respiratory syncytial virus (RSV) is a major cause of respiratory illness in young children. RSV infection produces a variety of signs and symptoms involving different areas of the respiratory tract, from the nose to the lungs. RSV is a negative sense, enveloped RNA virus. The virion is variable in shape and size with average diameter of between 120 and 300 nm. The 63 kD RSV fusion protein of the RSS 2 strain (subtype A) directs fusion of viral and cellular membranes, results in viral penetration, and can direct fusion of infected cells with adjoining cells, resulting in the formation of syncytia or multi nucleated giant cells.

Function:
Attaches the virion to the host cell membrane by interacting with heparan sulfate, initiating the infection. Interacts with host CX3CR1, the receptor for the CX3C chemokine fractalkine, to modulate the immune response and facilitate infection. Unlike the other paramyxovirus attachment proteins, lacks both neuraminidase and hemagglutinating activities.
Secreted glycoprotein G helps RSV escape antibody-dependent restriction of replication by acting as an antigen decoy and by modulating the activity of leukocytes bearing Fcgamma receptors.

Subunit:
Homooligomer. Interacts (via N-terminus) with protein M. Interacts with protein F; this interaction occurs on the surface of infected cells. Interacts with protein SH. Interacts with host CX3CR1; this interaction modulates host immune response.

Subcellular Location:
Virion membrane. Host cell surface. Isoform Secreted glycoprotein G: Secreted.

Post-translational modifications:
May carry 40-80 separate O-linked carbohydrate chains distributed among the 91 serine and threonine residues.
Palmitoylated.

Similarity:
Belongs to the pneumoviruses glycoprotein G family.

Database links:

 



Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.

呼吸道合胞病毒引起的急性呼吸道傳染病,該病毒能使病變細胞融合成多核巨細胞,故稱此名。 呼吸道合胞病毒是一種RNA病毒,屬副粘液病毒科。該病經空氣飛沫和密切接觸傳播。多見于新生兒和6 個月以內的嬰兒。潛伏期3~7日。嬰幼兒癥狀較重,可有高熱、鼻炎、咽炎及喉炎,以后表現為細支氣管炎及肺炎。少數病兒可并發中耳炎、胸膜炎及心肌炎等。成人和年長兒童感染后,主要表現為上呼吸道感染。
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