麻豆av资源_日本三级一区_www.狠狠艹_国产精妇在线观看第一区_成人性生交大片免费看中国A片_日本一本久久

掃碼關(guān)注公眾號           掃碼咨詢技術(shù)支持           掃碼咨詢技術(shù)服務(wù)
  
客服熱線:400-901-9800  客服QQ:4009019800  技術(shù)答疑  技術(shù)支持  質(zhì)量反饋  關(guān)于我們  聯(lián)系我們
国产精区,日韩免费成人,国产精品高潮呻吟av久久4虎
首頁 > 產(chǎn)品中心 > 標記一抗 > 產(chǎn)品信息
Rabbit Anti-Klotho/HRP Conjugated antibody (bs-2925R-HRP)
訂購熱線:400-901-9800
訂購郵箱:sales@bioss.com.cn
訂購QQ:  400-901-9800
技術(shù)支持:techsupport@bioss.com.cn
說 明 書: 100ul  
100ul/2980.00元
大包裝/詢價
產(chǎn)品編號 bs-2925R-HRP
英文名稱 Rabbit Anti-Klotho/HRP Conjugated antibody
中文名稱 辣根過氧化物酶標記的Klotho多肽蛋白抗體
別    名 KL antibody KLOT_HUMAN; Klotho peptide.  
規(guī)格價格 100ul/2980元 購買        大包裝/詢價
說 明 書 100ul  
研究領(lǐng)域 腫瘤  細胞生物  免疫學(xué)  發(fā)育生物學(xué)  信號轉(zhuǎn)導(dǎo)  新陳代謝  
抗體來源 Rabbit
克隆類型 Polyclonal
交叉反應(yīng) Mouse,  (predicted: Human, Rat, Dog, Pig, Cow, Horse, Rabbit, )
產(chǎn)品應(yīng)用 WB=1:500-2000 ELISA=1:100-1000 IHC-P=1:50-200 IHC-F=1:50-200 
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
分 子 量 113kDa
性    狀 Lyophilized or Liquid
濃    度 1mg/ml
免 疫 原 KLH conjugated synthetic peptide derived from human Klotho
亞    型 IgG
純化方法 affinity purified by Protein A
儲 存 液 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
保存條件 Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C.
產(chǎn)品介紹 background:
May have weak glycosidase activity towards glucuronylated steroids. However, it lacks essential active site Glu residues at positions 239 and 872, suggesting it may be inactive as a glycosidase in vivo. May be involved in the regulation of calcium and phosphorus homeostasis by inhibiting the synthesis of active vitamin D (By similarity). Essential factor for the specific interaction between FGF23 and FGFR1. The Klotho peptide generated by cleavage of the membrane-bound isoform may be an anti-aging circulating hormone which would extend life span by inhibiting insulin/IGF1 signaling.

Function:
May have weak glycosidase activity towards glucuronylated steroids. However, it lacks essential active site Glu residues at positions 239 and 872, suggesting it may be inactive as a glycosidase in vivo. May be involved in the regulation of calcium and phosphorus homeostasis by inhibiting the synthesis of active vitamin D (By similarity). Essential factor for the specific interaction between FGF23 and FGFR1 (By similarity).
The Klotho peptide generated by cleavage of the membrane-bound isoform may be an anti-aging circulating hormone which would extend life span by inhibiting insulin/IGF1 signaling (By similarity).

Subunit:
Belongs to the glycosyl hydrolase 1 family. Klotho subfamily.

Subcellular Location:
Isoform 1: Cell membrane; Single-pass type I membrane protein. Note=Isoform 1 shedding leads to a soluble peptide.
Isoform 2: Secreted.
Klotho peptide: Secreted.

Tissue Specificity:
Present in cortical renal tubules (at protein level). Soluble peptide is present in serum and cerebrospinal fluid. Expressed in kidney, placenta, small intestine and prostate. Down-regulated in renal cell carcinomas, hepatocellular carcinomas, and in chronic renal failure kidney.hepatocellular carcinomas, and in chronic renal failure kidney.

Post-translational modifications:
N-glycosylated.

DISEASE:
Present in cortical renal tubules (at protein level). Soluble peptide is Defects in KL are a cause of hyperphosphatemic familial tumoral calcinosis (HFTC) [MIM:211900]. A severe metabolic disorder that manifests with hyperphosphatemia and massive calcium deposits in the skin and subcutaneous tissues. Some patients manifest recurrent, transient, painful swellings of the long bones associated with the radiographic findings of periosteal reaction and cortical hyperostosis and absence of skin involvement.

Similarity:
Belongs to the glycosyl hydrolase 1 family. Klotho subfamily.

Database links:

Entrez Gene: 9365 Human

Entrez Gene: 16591 Mouse

Omim: 604824 Human

SwissProt: Q9UEF7 Human

SwissProt: O35082 Mouse

Unigene: 524953 Human

Unigene: 6500 Mouse



Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
版權(quán)所有 2004-2026 m.jywcc.com 北京博奧森生物技術(shù)有限公司
通過國際質(zhì)量管理體系ISO 9001:2015 GB/T 19001-2016    證書編號: 00124Q34771R2M/1100
通過國際醫(yī)療器械-質(zhì)量管理體系ISO 13485:2016 GB/T 42061-2022    證書編號: CQC24QY10047R0M/1100
京ICP備05066980號-1         京公網(wǎng)安備110107000727號
主站蜘蛛池模板: 国产精品男女猛烈高潮激情 | 在线观看免费观看在 | av成人资源网 | 日本aⅴ日本高清视频影片www | av亚洲精华国产精华 | 人与动人物a级毛片在线 | 日韩视频中文字幕精品偷拍 | 日本三级aaa | 国产精品一区二区麻豆 | 亚洲欧洲日韩淙合久久 | 日本一卡精品视频免费 | 亚洲国产香蕉碰碰人人 | 久久亚洲国产精品亚洲老地址 | 亚洲一区二区三区中文字幕在线观看 | 狠狠干2020| 欧美av在线 | 欧美精品无码一区二区三区19 | 久久精品30| 综合婷婷色 | 亚洲综合小说区图片 | 欧美交受高潮1 | 黄瓜视频入口永久免费观看 | 亚洲网站www | 91网址| 亚洲精品成AV人片天堂无码 | 欧美日本国产精品 | 国产精品久久久久久久久久影院的 | 精品国产肉丝袜久久 | 久久久久久久国产毛片 | 国语少妇高潮对白在线 | 国产毛片18片毛一级特黄 | 欧美劲爆婷婷五月久久 | 午夜DJ国产精华日本无码 | 日本中文不卡视频 | 国产99区| 在线视频自拍 | 免费观看日韩一级片 | 在线中文一区 | 国产精品乱子 | 欧美xxxx96| 日本在线a视频 |